Cilt 11, Sayı 2, Sayfalar 93 - 98 2017-08-20

Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats

Babatunde E. Arayombo [1] , Olarinde S. Adewole [2] , David A. Ofusori [3] , Taiwo S. Adelodun [4] , Stephen S. Olusola [5] , Ronald Bejide [6]

32 15

Objectives: The aim of this study was to assess and compare the ameliorative effect of zinc sulphate and Essentiale® Forte

on the histomorphology and lipid histochemistry of carbon tetrachloride (CCl4)-induced hepatic injury in adult Wistar rats.

Methods: Twenty-five adult Wistar rats, weighing between 150 g and 170 g, were used for the study. The animals were

divided into five groups A, B, C, D and E (n=5). Group A received 0.7 ml/kg of olive oil orally. Groups B, C, D and E were

administered CCl4 (0.7 ml/kg, orally) for 1 week in 1:1 dilution with olive oil. After CCl4 administration, Group C was treated

with Essentiale® Forte (4.5 mg/kg/bw, orally) for four weeks. Group D was treated with zinc sulphate (7 mg/kg/bw, orally)

daily for four weeks. Group E received zinc sulphate (7 mg/kg/bw, orally) and Essentiale® Forte (4.5 mg/kg/bw, orally) for

a period of 4 weeks, while Group B was left untreated. Animals were left for another one week and subsequently sacrificed

under ether anaesthesia. The liver was harvested, weighed and divided into two parts for histological and histochemical studies.

Results: Histological analysis showed that treatment of liver with CCl4 caused hepatotoxicity as marked by presence of

inflammatory cells and distortion in the connective tissue fibers, as compared to the ones treated with zinc sulphate and or

Essentiale® Forte which restored the hepatic histoarchitecture and protected the liver tissue from fatty and degenerative

changes.

Conclusion: This study showed that combination of Essentiale® Forte and zinc supplement offered better ameliorative

effects on the liver of Wistar rats following CCl4-induced hepatotoxicity compared with separate administration of either

Essentiale® Forte or zinc sulphate.

carbon tetrachloride; Essentiale® Forte; hepatotoxicity; liver; zinc sulphate
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Konular
Dergi Bölümü Original Articles
Yazarlar

Yazar: Babatunde E. Arayombo
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Yazar: Olarinde S. Adewole
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Yazar: David A. Ofusori
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Yazar: Taiwo S. Adelodun
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Yazar: Stephen S. Olusola
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Yazar: Ronald Bejide
E-posta: arayombo82@gmail.com
Ülke: Nigeria


Bibtex @araştırma makalesi { anatomy341903, journal = {Anatomy}, issn = {1307-8798}, address = {Türk Anatomi ve Klinik Anatomi Derneği}, year = {2017}, volume = {11}, pages = {93 - 98}, doi = {}, title = {Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats}, language = {en}, key = {cite}, author = {Adelodun, Taiwo S. and Olusola, Stephen S. and Bejide, Ronald and Adewole, Olarinde S. and Ofusori, David A. and Arayombo, Babatunde E.} }
APA Arayombo, B , Adewole, O , Ofusori, D , Adelodun, T , Olusola, S , Bejide, R . (2017). Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats. Anatomy, 11 (2), 93-98. Retrieved from http://dergipark.gov.tr/anatomy/issue/31323/341903
MLA Arayombo, B , Adewole, O , Ofusori, D , Adelodun, T , Olusola, S , Bejide, R . "Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats". Anatomy 11 (2017): 93-98 <http://dergipark.gov.tr/anatomy/issue/31323/341903>
Chicago Arayombo, B , Adewole, O , Ofusori, D , Adelodun, T , Olusola, S , Bejide, R . "Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats". Anatomy 11 (2017): 93-98
RIS TY - JOUR T1 - Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats AU - Babatunde E. Arayombo , Olarinde S. Adewole , David A. Ofusori , Taiwo S. Adelodun , Stephen S. Olusola , Ronald Bejide Y1 - 2017 PY - 2017 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 93 EP - 98 VL - 11 IS - 2 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2017 ER -
EndNote %0 Anatomy Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats %A Babatunde E. Arayombo , Olarinde S. Adewole , David A. Ofusori , Taiwo S. Adelodun , Stephen S. Olusola , Ronald Bejide %T Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats %D 2017 %J Anatomy %P 1307-8798-1308-8459 %V 11 %N 2 %R %U