Cilt 11, Sayı 2, Sayfalar 79 - 86 2017-08-20

Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex

Adekomi Damilare Adedayo [1] , Adewole Olarinde Stephen [2] , Tijani Ahmad Adekilekun [3] , Adeniyi Temidayo Daniel [4]

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Objectives: Lead (Pb) is a neurotoxicant heavy metal ubiquitously present in the eco-system. The precise mechanism by

which Pb confers its deleterious effects on the cellular profile of the central nervous system remains unknown. The aim of

this study was to investigate the effect of Pb on the medial prefrontal cortex (mPFC) using histological, immunohistological

and morphological techniques.

Methods: Thirthy juvenile male Wistar rats were used in this study. The rats were randomly assigned into three groups.

Group A served as the control group, Group B received 5 mg/kg Pb-nitrate (PbNO3) orally for 21 days, and Group C received

5 mg/kg PbNO3 and left for an additional 21 days to recover.

Results: There was a significant decrease in the number of normal neurons in the mPFC of the PbNO3-treated rats. The number

of degenerating neurons significantly increased in the PbNO3-treated groups compared with the control group. A

marked increase was observed in the number of astrocytic cell count in the PbNO3-treated groups compared with the control.

The neuronal cells in the cytoarchitectural profile of the mPFC of the rats receiving PbNO3 showed marked neurodegenerative

modification with features of distorted morphology, swollen and vacuolized cytoplasm, and features of either

pyknotic or karyorrhectic nuclei. The cytoarchitecture of the mPFC of the rats in the control group preserved the normal histological

outline suggestive of a normal and functional mPFC.

Conclusion: Exposure to Pb ingestion can result in significant inflammatory responses in the cytoarchitectural profile of the

mPFC. Furthermore, 21 days of cessation of exposure to PbNO3 did not halt or reverse the deleterious effects of Pb on the

mPFC of the rats, suggesting that Pb persists in the central nervous system of the rats.

astrogliosis; cell death; heavy metals; neurodegeneration; pathology
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Konular
Dergi Bölümü Original Articles
Yazarlar

Yazar: Adekomi Damilare Adedayo
E-posta: adedayo.adekomi@uniosun.edu.ng
Ülke: Nigeria


Yazar: Adewole Olarinde Stephen
E-posta: adedayo.adekomi@uniosun.edu.ng
Ülke: Nigeria


Yazar: Tijani Ahmad Adekilekun
E-posta: adedayo.adekomi@uniosun.edu.ng
Ülke: Nigeria


Yazar: Adeniyi Temidayo Daniel
E-posta: adedayo.adekomi@uniosun.edu.ng
Ülke: Nigeria


Bibtex @araştırma makalesi { anatomy341915, journal = {Anatomy}, issn = {1307-8798}, address = {Türk Anatomi ve Klinik Anatomi Derneği}, year = {2017}, volume = {11}, pages = {79 - 86}, doi = {}, title = {Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex}, language = {en}, key = {cite}, author = {Adekilekun, Tijani Ahmad and Stephen, Adewole Olarinde and Daniel, Adeniyi Temidayo and Adedayo, Adekomi Damilare} }
APA Adedayo, A , Stephen, A , Adekilekun, T , Daniel, A . (2017). Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex. Anatomy, 11 (2), 79-86. Retrieved from http://dergipark.gov.tr/anatomy/issue/31323/341915
MLA Adedayo, A , Stephen, A , Adekilekun, T , Daniel, A . "Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex". Anatomy 11 (2017): 79-86 <http://dergipark.gov.tr/anatomy/issue/31323/341915>
Chicago Adedayo, A , Stephen, A , Adekilekun, T , Daniel, A . "Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex". Anatomy 11 (2017): 79-86
RIS TY - JOUR T1 - Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex AU - Adekomi Damilare Adedayo , Adewole Olarinde Stephen , Tijani Ahmad Adekilekun , Adeniyi Temidayo Daniel Y1 - 2017 PY - 2017 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 79 EP - 86 VL - 11 IS - 2 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2017 ER -
EndNote %0 Anatomy Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex %A Adekomi Damilare Adedayo , Adewole Olarinde Stephen , Tijani Ahmad Adekilekun , Adeniyi Temidayo Daniel %T Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex %D 2017 %J Anatomy %P 1307-8798-1308-8459 %V 11 %N 2 %R %U