Yıl 2017, Cilt 11, Sayı 3, Sayfalar 107 - 114 2017-12-15

Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats

Tolulope Timothy Arogundade [1] , Bernard Ufuoma Enaibe [2] , Oluwaseun Olaniyi Adigun [3] , Foyeke Munirat Adigun [4] , Ismail Temitayo Gbadamosi [5]

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Objectives: Mustard seeds, apart from being a culinary essential, have had medicinal applications dating back to the time of Hippocrates. It has in fact been once mentioned as the greatest herb ever. We explored the dose dependent effects of the crude aqueous extract of Brassica nigra (Black mustard seeds) on the prefrontal cortex of adult Wistar rats.


Methods: 20 adult female rats weighing an average of 180±20 g were used. They were split into 4 groups (n=5); Group A

(received extract at 200 mg/kg body weight), Group B (received extract at 100 mg/kg body weight), Group C (received extract at 50 mg/kg body weight), and Group D (received distilled water ad libitum). All of the animals were subjected to the Y-maze spontaneous alternation test for neurobehavioural analyses following 28-day administration of the extracts. Animals were sacrificed 24 hours after taking the last day of administration.


Results: Our results showed that neurobehavioural analyses are significantly hampered in animals receiving 200 mg/kg extract in comparison to the control group. In treatment groups, increased dose of extract elevated the level of MDA, but reduced the level of SOD. LDH levels were also significantly increased in the 200 mg/kg treated group when comparing with the control. General microarchitecture in the prefrontal cortex of 200 mg/kg Brassica nigra treated group showed signs of karyolysis and pyknosis.


Conclusion: Brassica nigra (black mustard) is not innocuous and therefore it should be consumed in moderation.


Brassica nigra; neurobehaviour; neurototoxicity; prefrontal cortex
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Konular Sağlık Bilimleri
Dergi Bölümü Original Articles
Yazarlar

Yazar: Tolulope Timothy Arogundade
E-posta: arogundadetolulope@gmail.com
Ülke: Nigeria


Yazar: Bernard Ufuoma Enaibe
E-posta: arogundadetolulope@gmail.com
Ülke: Nigeria


Yazar: Oluwaseun Olaniyi Adigun
E-posta: arogundadetolulope@gmail.com
Ülke: Nigeria


Yazar: Foyeke Munirat Adigun
E-posta: arogundadetolulope@gmail.com
Ülke: Nigeria


Yazar: Ismail Temitayo Gbadamosi
E-posta: arogundadetolulope@gmail.com
Ülke: Nigeria


Bibtex @araştırma makalesi { anatomy385393, journal = {Anatomy}, issn = {1307-8798}, address = {Türk Anatomi ve Klinik Anatomi Derneği}, year = {2017}, volume = {11}, pages = {107 - 114}, doi = {}, title = {Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats}, key = {cite}, author = {Timothy Arogundade, Tolulope and Olaniyi Adigun, Oluwaseun and Temitayo Gbadamosi, Ismail and Munirat Adigun, Foyeke and Ufuoma Enaibe, Bernard} }
APA Timothy Arogundade, T , Ufuoma Enaibe, B , Olaniyi Adigun, O , Munirat Adigun, F , Temitayo Gbadamosi, I . (2017). Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats. Anatomy, 11 (3), 107-114. Retrieved from http://dergipark.gov.tr/anatomy/issue/34659/385393
MLA Timothy Arogundade, T , Ufuoma Enaibe, B , Olaniyi Adigun, O , Munirat Adigun, F , Temitayo Gbadamosi, I . "Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats". Anatomy 11 (2017): 107-114 <http://dergipark.gov.tr/anatomy/issue/34659/385393>
Chicago Timothy Arogundade, T , Ufuoma Enaibe, B , Olaniyi Adigun, O , Munirat Adigun, F , Temitayo Gbadamosi, I . "Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats". Anatomy 11 (2017): 107-114
RIS TY - JOUR T1 - Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats AU - Tolulope Timothy Arogundade , Bernard Ufuoma Enaibe , Oluwaseun Olaniyi Adigun , Foyeke Munirat Adigun , Ismail Temitayo Gbadamosi Y1 - 2017 PY - 2017 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 107 EP - 114 VL - 11 IS - 3 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2017 ER -
EndNote %0 Anatomy Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats %A Tolulope Timothy Arogundade , Bernard Ufuoma Enaibe , Oluwaseun Olaniyi Adigun , Foyeke Munirat Adigun , Ismail Temitayo Gbadamosi %T Dose-dependent effect of black mustard seeds (Brassica nigra) extract on the prefrontal cortex of adult Wistar rats %D 2017 %J Anatomy %P 1307-8798-1308-8459 %V 11 %N 3 %R %U