Yıl 2018, Cilt 12, Sayı 1, Sayfalar 1 - 6 2018-06-04

Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether

Idorenyin Udo Umoh [1] , Etukudoh Okon Jimmy [2]

45 76

Objectives: Foetal hepatorenal toxicity and foetal morphology were evaluated following artemether administration to pregnant

Wistar albino rats.

Methods: Twenty pregnant Wistar rats weighing between 180–200 g were divided into four groups (n=5, each) with Group 1

serving as the control. Groups 2, 3 and 4 received 1.1 mg, 2.2 mg and 3.3 mg per kilogram body weight artemether, respectively

orally, twice daily for three days on day 7, 8 and 9 of pregnancy. The animals were sacrificed on day 20 of pregnancy and foetuses

were harvested and evaluated for morphological changes. Foetal body weight and crown-rump length (CRL) were measured;

alpha-fetoprotein (AFP) was assayed using amniotic fluid, and foetal kidney and liver were evaluated histologically for toxicity.

Results: There was a significant decrease in body weight, CRL and AFP of the treated groups compared to the control. The foetal

liver of the treated groups revealed distorted cytoarchitecture, marked hepatocyte inflammation and hepatic necrosis. The foetal

kidney of artemether-treated groups also showed disorganised renal structure, atrophic and degenerated glomeruli with acute

tubular necrosis.

Conclusion: Artemether administration to pregnant albino rats causes intrauterine growth retardation or stunted growth,

as well as foetal hepatorenal toxicity.

alpha-fetoprotein; artemether; foetal hepatorenal toxicity; pregnancy
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Konular Sağlık Bilimleri
Dergi Bölümü Original Articles
Yazarlar

Yazar: Idorenyin Udo Umoh
Kurum: UDO UNIVERSITY
Ülke: Nigeria


Yazar: Etukudoh Okon Jimmy
Kurum: UDO UNIVERSITY
Ülke: Nigeria


Bibtex @araştırma makalesi { anatomy430164, journal = {Anatomy}, issn = {1307-8798}, eissn = {1308-8459}, address = {Türk Anatomi ve Klinik Anatomi Derneği}, year = {2018}, volume = {12}, pages = {1 - 6}, doi = {}, title = {Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether}, key = {cite}, author = {Udo Umoh, Idorenyin and Jimmy, Etukudoh Okon} }
APA Udo Umoh, I , Jimmy, E . (2018). Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether. Anatomy, 12 (1), 1-6. Retrieved from http://dergipark.gov.tr/anatomy/issue/37227/430164
MLA Udo Umoh, I , Jimmy, E . "Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether". Anatomy 12 (2018): 1-6 <http://dergipark.gov.tr/anatomy/issue/37227/430164>
Chicago Udo Umoh, I , Jimmy, E . "Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether". Anatomy 12 (2018): 1-6
RIS TY - JOUR T1 - Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether AU - Idorenyin Udo Umoh , Etukudoh Okon Jimmy Y1 - 2018 PY - 2018 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 1 EP - 6 VL - 12 IS - 1 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2018 ER -
EndNote %0 Anatomy Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether %A Idorenyin Udo Umoh , Etukudoh Okon Jimmy %T Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether %D 2018 %J Anatomy %P 1307-8798-1308-8459 %V 12 %N 1 %R %U
ISNAD Udo Umoh, Idorenyin , Jimmy, Etukudoh Okon . "Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether". Anatomy 12 / 1 (Haziran 2018): 1-6.