2016-10-01

Computational prediction of RNA-protein interactions

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RNA-protein interactions play critical roles in diverse cellular processes including post-transcriptional regulation of gene expression and infection by pathogens. As such, characterization of RNA-protein interactions will lead to a better understanding of these mechanisms and associated diseases.  Experimental methods to determine RNA-protein interactions remain tedious and expensive. An alternative strategy is to use computational methods to predict RNA-protein interactions. Here, we develop a random forest model that uses sequence information of an RNA-protein pair to determine whether they will interact or not. We evaluate our model with three diverse datasets including one dataset that has never been used for this purpose before. For the two other datasets, our model gives a better performance than existing methods. We also show that including features that represent the physico-chemical properties of the protein or RNA secondary structure. Altogether, these results show that RNA-protein interactions can be predicted accurately with computational models. 

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Bibtex @ { apjes287000, journal = {Akademik Platform Mühendislik ve Fen Bilimleri Dergisi}, issn = {}, eissn = {2147-4575}, address = {Akademik Platform}, year = {2016}, pages = { - }, doi = {10.21541/apjes.92217}, title = {Computational prediction of RNA-protein interactions}, key = {cite}, author = {} }
APA . (2016). Computational prediction of RNA-protein interactions. Akademik Platform Mühendislik ve Fen Bilimleri Dergisi, , . DOI: 10.21541/apjes.92217
MLA . "Computational prediction of RNA-protein interactions". Akademik Platform Mühendislik ve Fen Bilimleri Dergisi (2016): <http://dergipark.gov.tr/apjes/article/287000>
Chicago . "Computational prediction of RNA-protein interactions". Akademik Platform Mühendislik ve Fen Bilimleri Dergisi (2016):
RIS TY - JOUR T1 - Computational prediction of RNA-protein interactions AU - Y1 - 2016 PY - 2016 N1 - doi: 10.21541/apjes.92217 DO - 10.21541/apjes.92217 T2 - Akademik Platform Mühendislik ve Fen Bilimleri Dergisi JF - Journal JO - JOR SP - EP - SN - -2147-4575 M3 - doi: 10.21541/apjes.92217 UR - http://dx.doi.org/10.21541/apjes.92217 Y2 - 2018 ER -
EndNote %0 Akademik Platform Mühendislik ve Fen Bilimleri Dergisi Computational prediction of RNA-protein interactions %A %T Computational prediction of RNA-protein interactions %D 2016 %J Akademik Platform Mühendislik ve Fen Bilimleri Dergisi %P -2147-4575 %R doi: 10.21541/apjes.92217 %U 10.21541/apjes.92217