Cilt 4, Sayı 3, Sayfalar 0 - 0 2016-10-01

Computational prediction of RNA-protein interactions

Hilal Kazan [1]

535 246

RNA-protein interactions play critical roles in diverse cellular processes including post-transcriptional regulation of gene expression and infection by pathogens. As such, characterization of RNA-protein interactions will lead to a better understanding of these mechanisms and associated diseases.  Experimental methods to determine RNA-protein interactions remain tedious and expensive. An alternative strategy is to use computational methods to predict RNA-protein interactions. Here, we develop a random forest model that uses sequence information of an RNA-protein pair to determine whether they will interact or not. We evaluate our model with three diverse datasets including one dataset that has never been used for this purpose before. For the two other datasets, our model gives a better performance than existing methods. We also show that including features that represent the physico-chemical properties of the protein or RNA secondary structure. Altogether, these results show that RNA-protein interactions can be predicted accurately with computational models. 

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Konular
Dergi Bölümü Makaleler
Yazarlar

Yazar: Hilal Kazan
E-posta: hilal.kazan@antalya.edu.tr

Bibtex @ { apjes287563, journal = {Academic Platform-Journal of Engineering and Science}, issn = {}, address = {Akademik Platform}, year = {2016}, volume = {4}, pages = {0 - 0}, doi = {10.21541/apjes.92217}, title = {Computational prediction of RNA-protein interactions}, language = {en}, key = {cite}, author = {Kazan, Hilal} }
APA Kazan, H . (2016). Computational prediction of RNA-protein interactions. Academic Platform-Journal of Engineering and Science, 4 (3), 0-0. DOI: 10.21541/apjes.92217
MLA Kazan, H . "Computational prediction of RNA-protein interactions". Academic Platform-Journal of Engineering and Science 4 (2016): 0-0 <http://dergipark.gov.tr/apjes/issue/27314/287563>
Chicago Kazan, H . "Computational prediction of RNA-protein interactions". Academic Platform-Journal of Engineering and Science 4 (2016): 0-0
RIS TY - JOUR T1 - Computational prediction of RNA-protein interactions AU - Hilal Kazan Y1 - 2016 PY - 2016 N1 - doi: 10.21541/apjes.92217 DO - 10.21541/apjes.92217 T2 - Academic Platform-Journal of Engineering and Science JF - Journal JO - JOR SP - 0 EP - 0 VL - 4 IS - 3 SN - -2147-4575 M3 - doi: 10.21541/apjes.92217 UR - http://dx.doi.org/10.21541/apjes.92217 Y2 - 2017 ER -
EndNote %0 Academic Platform-Journal of Engineering and Science Computational prediction of RNA-protein interactions %A Hilal Kazan %T Computational prediction of RNA-protein interactions %D 2016 %J Academic Platform-Journal of Engineering and Science %P -2147-4575 %V 4 %N 3 %R doi: 10.21541/apjes.92217 %U 10.21541/apjes.92217