Cilt 18, Sayı 3, Sayfalar 543 - 553 2017-06-30

CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS

Emel TAMAHKAR IRMAK [1]

276 242

Controlled drug release systems present a significant alternative to the conventional drug dosages providing drug release for prolonged time periods. Nanocomposite hydrogels offer an important potential for drug release with enhanced physicochemical properties. In this study, the preparation of carbon nanotube (CNT)-based Polyvinylalcohol-Polyvinylpyrolidone (PVA/PVP) nanocomposite hydrogels namely, CNT-25, CNT-50 and CNT-100 were succedded via the freeze/thawing method with the addition of different amounts of CNT. The nanocomposite hydrogels were characterized by swelling tests, FT-IR, DSC, SEM and BET measurements. It was determined that CNT-50 was the most suitable hydrogel for drug release studies having better morhological properties with homogenous distribution of CNT throughout the polymeric nanocomposite matrix. The release of 5-fluororacil (5-FU) as a model drug was investigated in-vitro. The release of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels was exhibited controlled release for one week at pH 7.4. The amount of released of 5-FU was effectively increased with the addition of CNT into the hydrogel matrix.  Korsmeyer-Peppas model was well fitted for determining the release mechanism of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels corresponding the combination of diffusion of the drug and the dissolution of polymer chains.  

Drug release systems,nanocomposite hydrogels,carbon nanotube,PVA/PVP hydrogels
Konular Mühendislik ve Temel Bilimler
Dergi Bölümü Araştırma Makalesi
Yazarlar

Yazar: Emel TAMAHKAR IRMAK
E-posta: emeltamahkar@gmail.com

Bibtex @ { aubtda322138, journal = {Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik}, issn = {1302-3160}, address = {Anadolu Üniversitesi}, year = {2017}, volume = {18}, pages = {543 - 553}, doi = {10.18038/aubtda.322138}, title = {CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS}, language = {en}, key = {cite}, author = {TAMAHKAR IRMAK, Emel} }
APA TAMAHKAR IRMAK, E . (2017). CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik, 18 (3), 543-553. DOI: 10.18038/aubtda.322138
MLA TAMAHKAR IRMAK, E . "CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS". Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik 18 (2017): 543-553 <http://dergipark.gov.tr/aubtda/issue/30003/322138>
Chicago TAMAHKAR IRMAK, E . "CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS". Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik 18 (2017): 543-553
RIS TY - JOUR T1 - CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS AU - Emel TAMAHKAR IRMAK Y1 - 2017 PY - 2017 N1 - doi: 10.18038/aubtda.322138 DO - 10.18038/aubtda.322138 T2 - Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik JF - Journal JO - JOR SP - 543 EP - 553 VL - 18 IS - 3 SN - 1302-3160-2146-0205 M3 - doi: 10.18038/aubtda.322138 UR - http://dx.doi.org/10.18038/aubtda.322138 Y2 - 2017 ER -
EndNote %0 Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS %A Emel TAMAHKAR IRMAK %T CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS %D 2017 %J Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler ve Mühendislik %P 1302-3160-2146-0205 %V 18 %N 3 %R doi: 10.18038/aubtda.322138 %U 10.18038/aubtda.322138