Cilt 6, Sayı 2, Sayfalar 103 - 113 2017-08-31

DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER
PARASPORINS AS A NATURAL ANTI-CANCER PROTEIN

Müjgan Kesik Oktay [1] , Hatice Güneş [2]

15 28

Bacillus thuringiensis doğada geniş yayılım gösteren, gram pozitif ve spor oluşturan bir bakteridir. Sporulasyon evresinde, sporlarla birlikte birçok böcek çeşidine karşı insektisit etki gösteren kristal proteinleri de üretir. İnsektisidal kristal proteinler Cry ve Cyt proteinler olup; aktivitelerini duyarlı böceklerin orta barsak membranlarında bulunan reseptöre bağlanarak gösterirler. Bu reseptör bağlantılı özgül aktivitelerinden dolayı zirai mücadelede önemlidirler. Daha sonraları, insektisit olanlara göre doğada daha geniş dağılım gösteren insektisit olmayan kristal proteinler üzerindeki çalışmalar yeni bir protein sınıfı olan parasporinleri ortaya çıkarmıştır. Parasporinler ayrıcalıklı olarak kanser hücrelerine karşı sitotoksik etki gösterirken normal hücrelere etki etmez ve hemolitik etki göstermez. Şimdiye kadar altı parasporin ailesi tanımlanmış olup toplamda 19 alt grup bilinmektedir. Parasporinler de insektisidal kristal proteinlere benzer şekilde reseptör bağlantılı etki gösterdiğinden kanser tedavisiyle ilgili çalışmalarda yeni bir araştırma alanının ortaya çıkmasını sağlamıştır. Bu derlemede; parasporinlerin keşfi, özellikleri, çeşitleri ve etki mekanizmaları hakkında yapılmış olan çalışmalar özetle anlatılmıştır.

Bacillus thuringiensis (Bt) is a gram positive and spore forming bacterium that shows a wide distribution in the nature.  During the sporulation phase, it produces insecticidal crystal proteins along with spores. These insecticidal proteins are called Cry and Cyt proteins and have an activity when binding to spesific receptor located on the plasma membrane of mid-gut epithelial cells of susceptible insects. This receptor mediated spesific activity makes Bt important in agricultural control of insects. Afterwards, research on non-insecticidal proteins that have a wider distribution in nature than insecticidal ones revealed a new protein class called parasporin. Parasporins are capable of discriminately killing cancer cells while does not show cytotoxic and hemolytic activity against normal cells. So far, six parasporin families have been defined and a total of 19 sub-group is known.  Because  parasporins have a similar spesific-receptor binding effect with insecticidal crystal proteins,  they had led to emergence of a new research field related to cancer treatment.  This study reviewed the discovery of parasporins, their characteristics, varieties and their mechanisms of action on cancer cells.

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Konular Yaşam Bilimleri
Dergi Bölümü Derleme
Yazarlar

Yazar: Müjgan Kesik Oktay
E-posta: mujgank@mu.edu.tr
Kurum: muğla sıtkı koçman üniversitesi
Ülke: Turkey


Yazar: Hatice Güneş
E-posta: haticegunes@mu.edu.tr
Kurum: muğla sıtkı koçman üniversitesi
Ülke: Turkey


Bibtex @derleme { aubtdc307261, journal = {Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji}, issn = {2146-0264}, address = {Anadolu Üniversitesi}, year = {2017}, volume = {6}, pages = {103 - 113}, doi = {10.18036/aubtdc.307261}, title = {DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER}, language = {tr}, key = {cite}, author = {Kesik Oktay, Müjgan and Güneş, Hatice} } @derleme { aubtdc307261, journal = {Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji}, issn = {2146-0264}, address = {Anadolu Üniversitesi}, year = {2017}, volume = {6}, pages = {103 - 113}, doi = {10.18036/aubtdc.307261}, title = {PARASPORINS AS A NATURAL ANTI-CANCER PROTEIN}, language = {en}, key = {cite}, author = {Kesik Oktay, Müjgan and Güneş, Hatice} }
APA Kesik Oktay, M , Güneş, H . (2017). DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, 6 (2), 103-113. DOI: 10.18036/aubtdc.307261
MLA Kesik Oktay, M , Güneş, H . "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER". Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 6 (2017): 103-113 <http://dergipark.gov.tr/aubtdc/issue/30634/307261>
Chicago Kesik Oktay, M , Güneş, H . "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER". Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 6 (2017): 103-113
RIS TY - JOUR T1 - DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER AU - Müjgan Kesik Oktay , Hatice Güneş Y1 - 2017 PY - 2017 N1 - doi: 10.18036/aubtdc.307261 DO - 10.18036/aubtdc.307261 T2 - Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji JF - Journal JO - JOR SP - 103 EP - 113 VL - 6 IS - 2 SN - 2146-0264-2146-0213 M3 - doi: 10.18036/aubtdc.307261 UR - http://dx.doi.org/10.18036/aubtdc.307261 Y2 - 2017 ER -
EndNote %0 Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER %A Müjgan Kesik Oktay , Hatice Güneş %T DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER %D 2017 %J Anadolu Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji %P 2146-0264-2146-0213 %V 6 %N 2 %R doi: 10.18036/aubtdc.307261 %U 10.18036/aubtdc.307261