Yıl 2018, Cilt 14, Sayı 1, Sayfalar 51 - 55 2018-03-30

The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos

Beyhan Gürcü [1] , Tülay Oludağ Mete [2] , Fatih Çöllü [3] , Işıl Aydemir [4] , M. İbrahim Tuğlu [5]

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Antiepileptic drugs (AED) are teratogens that confer a risk of various congenital malformations including neural tube defects. Lacosamide (LCM) is a novel third-generation AED and its effects on neural tube (NT) development remain unclear. Thus, the aim of the present study was to investigate the effects of LCM in the early stages of NT development in the chicken embryo. Three different doses of LCM were applied under the embryonic disks of chicken embryos after they were incubated for 30 hours. Incubation was continued for an additional 80 hours and then all embryos were obtained for routine histology. In the LCM-treated groups, there was occlusion in the middle and ventral levels of the cavity. In the group treated with 1.60 mg of LCM, the NT cavity was closed, the notochord exhibited deterioration, and cellular association appeared abnormal. In the groups treated with 0.12 and 0.5 mg of LCM, the ectoderm layer surrounding the embryo was hypertrophic and the number of pyknotic cells increased in a dose-dependent manner. Thus, different doses of LCM had different effects. The results of this study demonstrated that LCM causes histopathological alterations during the neurulation stage that might ultimately result in the development of congenital defects and/or malformations.

Lacosamide, Histopathology, Neural tube, Chick
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Orcid: orcid.org/0000-0001-7667-7155
Yazar: Beyhan Gürcü
Kurum: Manisa Celal Bayar University
Ülke: Turkey


Yazar: Tülay Oludağ Mete

Yazar: Fatih Çöllü

Yazar: Işıl Aydemir

Yazar: M. İbrahim Tuğlu

Bibtex @araştırma makalesi { cbayarfbe342317, journal = {Celal Bayar Üniversitesi Fen Bilimleri Dergisi}, issn = {1305-130X}, eissn = {1305-1385}, address = {Celal Bayar Üniversitesi}, year = {2018}, volume = {14}, pages = {51 - 55}, doi = {10.18466/cbayarfbe.342317}, title = {The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos}, key = {cite}, author = {Oludağ Mete, Tülay and Tuğlu, M. İbrahim and Aydemir, Işıl and Çöllü, Fatih and Gürcü, Beyhan} }
APA Gürcü, B , Oludağ Mete, T , Çöllü, F , Aydemir, I , Tuğlu, M . (2018). The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, 14 (1), 51-55. DOI: 10.18466/cbayarfbe.342317
MLA Gürcü, B , Oludağ Mete, T , Çöllü, F , Aydemir, I , Tuğlu, M . "The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos". Celal Bayar Üniversitesi Fen Bilimleri Dergisi 14 (2018): 51-55 <http://dergipark.gov.tr/cbayarfbe/issue/36240/342317>
Chicago Gürcü, B , Oludağ Mete, T , Çöllü, F , Aydemir, I , Tuğlu, M . "The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos". Celal Bayar Üniversitesi Fen Bilimleri Dergisi 14 (2018): 51-55
RIS TY - JOUR T1 - The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos AU - Beyhan Gürcü , Tülay Oludağ Mete , Fatih Çöllü , Işıl Aydemir , M. İbrahim Tuğlu Y1 - 2018 PY - 2018 N1 - doi: 10.18466/cbayarfbe.342317 DO - 10.18466/cbayarfbe.342317 T2 - Celal Bayar Üniversitesi Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 51 EP - 55 VL - 14 IS - 1 SN - 1305-130X-1305-1385 M3 - doi: 10.18466/cbayarfbe.342317 UR - http://dx.doi.org/10.18466/cbayarfbe.342317 Y2 - 2018 ER -
EndNote %0 Celal Bayar Üniversitesi Fen Bilimleri Dergisi The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos %A Beyhan Gürcü , Tülay Oludağ Mete , Fatih Çöllü , Işıl Aydemir , M. İbrahim Tuğlu %T The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos %D 2018 %J Celal Bayar Üniversitesi Fen Bilimleri Dergisi %P 1305-130X-1305-1385 %V 14 %N 1 %R doi: 10.18466/cbayarfbe.342317 %U 10.18466/cbayarfbe.342317
ISNAD Gürcü, Beyhan , Oludağ Mete, Tülay , Çöllü, Fatih , Aydemir, Işıl , Tuğlu, M. İbrahim . "The Effects of Lacosamide in the Early Stages of Neural Tube Development in Chick Embryos". Celal Bayar Üniversitesi Fen Bilimleri Dergisi 14 / 1 (Mart 2018): 51-55. http://dx.doi.org/10.18466/cbayarfbe.342317