Yıl 2018, Cilt 21, Sayı 2, Sayfalar 152 - 166 2018-07-20

Historical Development and Properties of Platelet Concentrates in Dentistry
Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri

Mehmet KIZILTOPRAK [1] , Mustafa özay USLU [2]

58 126

Platelets are playing a very important role in wound healing and hemostasis and are among the potential cells of regenerative therapy due to the growth factors and cytokines they contain. This has increased the interest in platelet and platelet concentrates in regenerative therapy. Various platelet concentrates from the past to the present day were obtained, and when these products were used alone or in combination with other biomaterials, positive contributions to the healing process were observed. When platelet concentrates are used in surgical procedures involving hard and soft tissue, they provide controlled release of intense cytokines and growth factors in their contents. This situation is accelerating the natural wound healing process. In addition, they are the most important advantages because they do not cause any immunological reaction and infection since they are autogenous. When whole blood is centrifuged at different cycle and different times, platelet derived products with different contents are obtained. Looking at the products such as PRP, PRGF, PRF and CGF, it is seen that each newly discovered product has more advanced characteristics than the previous one. The aim of review;  platelet concentrate's such as PRP, PRGF, PRF, CGF give information about the historical development and properties.

Trombositler hemostaz ve yara iyileşmesinde çok önemli bir rol oynamakta ve ihtiva ettikleri büyüme faktörleri ve sitokinler sayesinde rejeneratif tedavinin potansiyel hücreleri arasında yer almaktadırlar. Bu durum, rejeneratif tedavide, trombosit ve trombosit konsantrasyonlarına olan ilgiyi arttırmıştır. Geçmişten günümüze kadar çeşitli trombosit konsantrasyonları elde edilmiş ve bu ürünler tek başına veya başka biomateryallerle kombine kullanıldığında, iyileşme sürecine olan olumlu katkıları görülmüştür. Trombosit konsantrasyonları, sert ve yumuşak doku ile ilgili cerrahi prosedürlerde kullanıldığında, içeriğinde bulunan yoğun sitokin ve büyüme faktörlerinin kontrollü salınımı sağlar. Bu durum doğal yara iyileşme sürecini hızlandırmaktadır. Ayrıca, otojen kaynaklı olduklarından herhangi bir immünolojik reaksiyon ve enfeksiyona yol açmamaları en önemli avantajlarıdır. Tam kan farklı devirlerde ve farklı sürelerde santrifüj edildiğinde içeriği birbirinden farklı olan trombosit kaynaklı ürünler elde edilmiştir. PRP, PRGF, PRF ve CGF gibi ürünlere bakıldığında yeni keşfedilen her ürünün bir öncekine göre daha gelişmiş özellikleri olduğu görülmektedir.  Bu derlemenin amacı; PRP, PRGF, PRF ve CGF gibi trombosit konsantrasyonlarının tarihsel gelişimi ve özellikleri hakkında bilgi vermektir. 

  • 1. Koçyiğit İD, Tunalı M, Özdemir H, Kartal Y, Süer BT. İkinci nesil trombosit konsantrasyonunun klinik uygulamaları. Cumhuriyet Dent J 2012;15(3):279-87.
  • 2. Toker H, Alpan AL, Hocaoğlu TP. Management of Mandibular Osteomyelitis Combined with Platelet Rich Fibrin (PRF) and Ozone. Cumhuriyet Dent J 2016;19(3):189-96.
  • 3. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009;80(2):244-52.
  • 4. El-Sharkawy H, Kantarci A, Deady J, et al. Platelet-rich plasma: growth factors and pro-and anti-inflammatory properties. J Periodontol 2007;78(4):661-69.
  • 5. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004;114(6):1502-08.
  • 6. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 2006;118(6):147e-59e.
  • 7. Pierce GF, Mustoe TA, Altrock BW, Deuel TF, Thomason A. Role of platelet‐derived growth factor in wound healing. J Cell Biochem 1991;45(4):319-26.
  • 8. Qiao J, An N, Ouyang X. Quantification of growth factors in different platelet concentrates. Platelets 2017:1-5.
  • 9. Abel ME, Chiu YS, Russell TR, Volpe PA. Autologous fibrin glue in the treatment of rectovaginal and complex fistulas. Dis Colon Rectum 1993;36(5):447-49.
  • 10. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2006;101(3):e37-e44.
  • 11. Matras H, Dinges HP, Lassmann H, Mamoli B. [Suture-free interfascicular nerve transplantation in animal experiments]. Wien Med Wochenschr 1972;122(37):517-23.
  • 12. Matras H, Dinges H, Mamoli B, Lassmann H. Non-sutured nerve transplantation: a report on animal experiments. J Maxillofac Surg 1973;1:37-40.
  • 13. Gibble J, Ness P. Fibrin glue: the perfect operative sealant? Transfusion (Paris) 1990;30(8):741-47.
  • 14. Ferrari M, Zia S, Valbonesi M, et al. A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int J Artif Organs 1987;10(1):47-50.
  • 15. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85(6):638-46.
  • 16. Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet‐rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res 2008;19(6):539-45.
  • 17. Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg 2005;16(6):1043-54.
  • 18. Pallua N, Wolter T, Markowicz M. Platelet-rich plasma in burns. Burns 2010;36(1):4-8.
  • 19. Simon D, Manuel S, Geetha V, Naik BR. Potential for osseous regeneration of platelet-rich plasma--a comparative study in mandibular third molar sockets. Indian J Dent Res 2004;15(4):133-6.
  • 20. Weibrich G, Kleis WK, Buch R, Hitzler WE, Hafner G. The Harvest Smart PRePTM system versus the Friadent‐Schütze platelet‐rich plasma kit. Clin Oral Implants Res 2003;14(2):233-39.
  • 21. Weibrich G, Kleis WK, Hafner G, Hitzler W, Wagner W. Comparison of platelet, leukocyte, and growth factor levels in point‐of‐care platelet‐enriched plasma, prepared using a modified Curasan kit, with preparations received from a local blood bank. Clin Oral Implants Res 2003;14(3):357-62.
  • 22. Choi B-H, Zhu S-J, Kim B-Y, et al. Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. Int J Oral Maxillofac Surg 2005;34(4):420-24.
  • 23. Arora NS, Ramanayake T, Ren Y-F, Romanos GE. Platelet-rich plasma: a literature review. Implant Dent 2009;18(4):303-10.
  • 24. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14(4):529-35.
  • 25. Kobayashi E, Flückiger L, Fujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig 2016;20(9):2353-60.
  • 26. Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Ann Maxillofac Surg 2011;1(1):53.
  • 27. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101(3):e45-50.
  • 28. Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie 2001;42(55):e62.
  • 29. Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J 2014;4(1):3-9.
  • 30. Castro AB, Meschi N, Temmerman A, et al. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol 2017;44(1):67-82.
  • 31. Carroll R, Arnoczky S, Graham S, O’Connell S. Characterization of autologous growth factors in Cascade platelet rich fibrin matrix (PRFM). Edison, NJ: Musculoskeletal Transplant Foundation 2005.
  • 32. Verma UP, Yadav RK, Dixit M, Gupta A. Platelet-rich Fibrin: A Paradigm in Periodontal Therapy - A Systematic Review. J Int Soc Prev Community Dent 2017;7(5):227-33.
  • 33. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101(3):e51-5.
  • 34. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol 2010;81(4):546-55.
  • 35. Khorshidi H, Raoofi S, Bagheri R, Banihashemi H. Comparison of the mechanical properties of early leukocyte-and platelet-rich fibrin versus PRGF/endoret membranes. Int J Dent 2016;2016.
  • 36. Burnouf T, Goubran HA, Chen T-M, et al. Blood-derived biomaterials and platelet growth factors in regenerative medicine. Blood Rev 2013;27(2):77-89.
  • 37. Rowe SL, Lee S, Stegemann JP. Influence of thrombin concentration on the mechanical and morphological properties of cell-seeded fibrin hydrogels. Acta Biomater 2007;3(1):59-67.
  • 38. Yang L-C, Hu S-W, Yan M, et al. Antimicrobial activity of platelet-rich plasma and other plasma preparations against periodontal pathogens. J Periodontol 2015;86(2):310-18.
  • 39. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101(3):e56-60.
  • 40. Choukroun J. Advanced PRF, &i-PRF: platelet concentrates or blood concentrates. J Periodont Med Clin Practice 2014;1:3.
  • 41. Tajima N, Ohba S, Sawase T, Asahina I. Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich fibrin as sole grafting material. Int J Oral Maxillofac Implants 2013;28(1).
  • 42. Hauser F, Gaydarov N, Badoud I, et al. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study. Implant Dent 2013;22(3):295-303.
  • 43. Aleksić Z, Janković S, Dimitrijević B, et al. The use of platelet-rich fibrin membrane in gingival recession treatment. Srp Arh Celok Lek 2010;138(1-2):11-18.
  • 44. Rajaram V, Thyegarajan R, Ashwath Balachandran GA, Kanakamedala A. Platelet Rich Fibrin in double lateral sliding bridge flap procedure for gingival recession coverage: An original study. J Indian Soc Periodontol 2015;19(6):665.
  • 45. Meshram VS, Lambade PN, Meshram PV, Kadu A, Tiwari MS. The autologous platelet rich fibrin: A novel approach in osseous regeneration after cystic enucleation: A pilot study. Indian J Dent Res 2015;26(6):560.
  • 46. Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail. Acta Odontol Scand 2016;74(1):36-43.
  • 47. Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol 2011;82(10):1396-403.
  • 48. Sohn D-S, Heo J-U, Kwak D-H, et al. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent 2011;20(5):389-95.
  • 49. Rodella LF, Favero G, Boninsegna R, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech 2011;74(8):772-77.
  • 50. Yu B, Wang Z. Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro. Mol Med Report 2014;9(1):235-42.
  • 51. Kim J-M, Sohn D-S, Bae M-S, et al. Flapless transcrestal sinus augmentation using hydrodynamic piezoelectric internal sinus elevation with autologous concentrated growth factors alone. Implant Dent 2014;23(2):168-74.
  • 52. Qiao J, Duan J, Zhang Y, Chu Y, Sun C. The effect of concentrated growth factors in the treatment of periodontal intrabony defects. Future Sci OA 2016;2(4):Fs136.
  • 53. Qiao J, Duan J, Chu Y, Sun C. Effect of concentrated growth factors on the treatment of degree II furcation involvements of mandibular molars. Beijing da xue xue bao. Yi xue ban= Journal of Peking University. Health Sci 2017;49(1):36.
  • 54. Bozkurt Doğan Ş, Öngöz Dede F, Ballı U, Atalay EN, Durmuşlar MC. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split‐mouth randomized clinical trial. J Clin Periodontol 2015;42(9):868-75.
  • 55. Shyu S-S, Fu E, Shen E-C. Clinical and Microcomputed Topography Evaluation of the Concentrated Growth Factors as a Sole Material in a Cystic Bony Defect in Alveolar Bone Followed by Dental Implantation: A Case Report. Implant Dent 2016;25(5):707-14.
  • 56. Veis A, Barlas I, Georgakopoulos I, Poutachidis I, Barlas S. Treatment of paresthesia of the inferior alveolar nerve with implant removal and concentrated growth factors. a case report. Clin Oral Implants Res 2014;25:647.
  • 57. Wang F, Sun Y, He D, Wang L. Effect of Concentrated Growth Factors on the Repair of the Goat Temporomandibular Joint. J Oral Maxillofac Surg 2017;75(3):498-507.
Birincil Dil tr
Konular Sağlık Bilimleri
Dergi Bölümü Reviews
Yazarlar

Yazar: Mehmet KIZILTOPRAK
Ülke: Turkey


Yazar: Mustafa özay USLU (Sorumlu Yazar)
Ülke: Turkey


Bibtex @derleme { cumudj381546, journal = {Cumhuriyet Dental Journal}, issn = {1302-5805}, eissn = {2146-2852}, address = {Cumhuriyet Üniversitesi}, year = {2018}, volume = {21}, pages = {152 - 166}, doi = {10.7126/cumudj.381546}, title = {Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri}, key = {cite}, author = {USLU, Mustafa özay and KIZILTOPRAK, Mehmet} }
APA KIZILTOPRAK, M , USLU, M . (2018). Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri. Cumhuriyet Dental Journal, 21 (2), 152-166. DOI: 10.7126/cumudj.381546
MLA KIZILTOPRAK, M , USLU, M . "Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri". Cumhuriyet Dental Journal 21 (2018): 152-166 <http://dergipark.gov.tr/cumudj/issue/36953/381546>
Chicago KIZILTOPRAK, M , USLU, M . "Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri". Cumhuriyet Dental Journal 21 (2018): 152-166
RIS TY - JOUR T1 - Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri AU - Mehmet KIZILTOPRAK , Mustafa özay USLU Y1 - 2018 PY - 2018 N1 - doi: 10.7126/cumudj.381546 DO - 10.7126/cumudj.381546 T2 - Cumhuriyet Dental Journal JF - Journal JO - JOR SP - 152 EP - 166 VL - 21 IS - 2 SN - 1302-5805-2146-2852 M3 - doi: 10.7126/cumudj.381546 UR - http://dx.doi.org/10.7126/cumudj.381546 Y2 - 2018 ER -
EndNote %0 Cumhuriyet Dental Journal Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri %A Mehmet KIZILTOPRAK , Mustafa özay USLU %T Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri %D 2018 %J Cumhuriyet Dental Journal %P 1302-5805-2146-2852 %V 21 %N 2 %R doi: 10.7126/cumudj.381546 %U 10.7126/cumudj.381546
ISNAD KIZILTOPRAK, Mehmet , USLU, Mustafa özay . "Diş Hekimliğinde Trombosit Konsantrasyonlarinin Tarihsel Gelişimi ve Özellikleri". Cumhuriyet Dental Journal 21 / 2 (Temmuz 2018): 152-166. http://dx.doi.org/10.7126/cumudj.381546