Yıl 2018, Cilt 57, Sayı 2, Sayfalar 94 - 99 2018-06-28

Bone mineral density in obese children with prediabetes
Prediyabeti olan obez çocukların kemik mineral dansitometreleri

Ala Üstyol [1] , Mehmet Emre Atabek [2]

28 32

Aim: The aim of this study was to evaluate the relationships between bone mineral density (BMD) vs metabolic risk factors in obese adolescents with prediabetes. 

Materials and Methods: A total of 131 obese children and adolescents, aged 6-18 years of age were enrolled the study. Prediabetes was determined by a fasting blood glucose level of ≥100 to 125 mg/dL or 2-hour oral glucose tolerance test value of ≥140 to 199 mg/dL. Five patients who were diagnosed as having type 2 diabetes were excluded and remaining participants were classified as normal glucose tolerance (NGT) and prediabetic. BMD was measured on calcaneus using quantitative ultrasound. BMD and metabolic parameters were investigated and compared in these two groups.

Results: There was no significant difference in BMD between children and adolescents with prediabetes (n = 37) or NGT (n = 89). The parameters of prediabetes did not affect BMD and these results did not change when we adjusted for weight, height, age, sex, pubertal status. The multivariate linear regression analysis revealed that the only independent factor associated with higher BMD was higher BMI (OR=0.007 95%CI 0.002-0.013 p=0.013). No significant associations were found between BMD and waist circumference or biochemical measurements.
Conclusion: Plasma glucose within the prediabetic range is not associated with bone mineral density in obese children. Thus, the positive association of BMI with BMD may be by means of alternative pathways.

Amaç: Çalışmanın amacı prediyabetik obez çocuk ve ergenlerde kemik mineral dansitometresinin (KMD) metabolik faktörlerle ilişkisini araştırmaktır.

Gereç ve Yöntem: Çalışmaya 6-18 yaş arasında 131 adet çocuk ve ergen dahil edildi. Prediyabet kriteri açlık kan glikozunun ≥100-125 mg/dL aralığında olması yada glikoz yükleme testi 2. saat glikoz değerinin ≥140-199 mg/dL arasında olması olarak belirlendi. Bu ölçütlere göre tip 2 diyabet tanısı alan 5 hasta çalışma dışı tutulurken geri kalanlar prediyabet ve normal glikoz toleranslı (NGT) hastalar olmak üzere iki guruba ayrıldılar. KMD kalkaneustan kantitatif ultrason ölçüm cihazı ile yapıldı. Her iki grupta KMD ve metabolik parametreler karşılaştırıldı.
Bulgular: Gruplar arasında KMD açısından anlamlı bir fark yoktu. Prediyabet ölçütleri KMD‘yi etkilemiyor üstelik ağırlık, boy, yaş, cinsiyet ve ergenlik gibi KMD üzerine olası etkileri olabilecek parametrelere göre düzenleme sonrasında bu durum değişmiyordu. Lineer regresyon analizinde beden kitle indeksi (BKİ) ile KMD arasında pozitif ilişki bulundu. Bel çevresi ve diğer metabolik faktörler ile KMD arasında ise bir ilişki bulunamadı.
Sonuç: Prediyabetik aralıktaki glikoz değeri ile KMD arasında herhangi bir ilişki yoktur. Obez çocuklarda fazla BKİ ile KMD arasındaki pozitif korelasyonu açıklayacak bilinen metabolik parametreler dışında alternatif etkenler olabilir.

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Birincil Dil en
Konular Sağlık Bilimleri
Dergi Bölümü Araştırma Makaleleri
Yazarlar

Orcid: 0000-0001-7903-7356
Yazar: Ala Üstyol (Sorumlu Yazar)
Kurum: Necmettin Erbakan University Faculty of Medicine, Department of Pediatric Endocrinology, Konya
Ülke: Turkey


Orcid: 0000-0002-2242-9401
Yazar: Mehmet Emre Atabek
Kurum: Necmettin Erbakan University Faculty of Medicine, Department of Pediatric Endocrinology, Konya

Bibtex @araştırma makalesi { etd414976, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {Ege Üniversitesi}, year = {2018}, volume = {57}, pages = {94 - 99}, doi = {10.19161/etd.414976}, title = {Bone mineral density in obese children with prediabetes}, key = {cite}, author = {Atabek, Mehmet Emre and Üstyol, Ala} }
APA Üstyol, A , Atabek, M . (2018). Bone mineral density in obese children with prediabetes. Ege Tıp Dergisi, 57 (2), 94-99. DOI: 10.19161/etd.414976
MLA Üstyol, A , Atabek, M . "Bone mineral density in obese children with prediabetes". Ege Tıp Dergisi 57 (2018): 94-99 <http://dergipark.gov.tr/etd/issue/36516/414976>
Chicago Üstyol, A , Atabek, M . "Bone mineral density in obese children with prediabetes". Ege Tıp Dergisi 57 (2018): 94-99
RIS TY - JOUR T1 - Bone mineral density in obese children with prediabetes AU - Ala Üstyol , Mehmet Emre Atabek Y1 - 2018 PY - 2018 N1 - doi: 10.19161/etd.414976 DO - 10.19161/etd.414976 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 94 EP - 99 VL - 57 IS - 2 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.414976 UR - http://dx.doi.org/10.19161/etd.414976 Y2 - 2017 ER -
EndNote %0 Ege Tıp Dergisi Bone mineral density in obese children with prediabetes %A Ala Üstyol , Mehmet Emre Atabek %T Bone mineral density in obese children with prediabetes %D 2018 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 57 %N 2 %R doi: 10.19161/etd.414976 %U 10.19161/etd.414976