Year 2019, Volume 58, Issue 1, Pages 92 - 102 2019-03-14

Do metallic implants make allergies?
Metalik implantlar alerji yapar mı?

Fatma Düşünür Günsen [1] , Aytül Zerrin Sin [2] , Semih Aydoğdu [3]

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Sensitivity to metals is very common, especially to nickel. Implanted metals corrode when in contact with biological fluids and release iron, chromium, nickel, aluminium, molybdenum etc. metallic ions. These metal ions may cause local or systemic effects and induce hypersensitivity reactions. Cutaneous reactions over the implanted device are primarily T-cell mediated type 4 delayed-type reactions. Patch test evaluation is the gold standard for searching metal hypersensitivity. Routine pre-implant patch testing is not recommended; if the patient has a personal metal allergy history, it should be performed before operation. Currently available testing methods cannot predict which patients will develop hypersensitivity reactions following insertion of metalic implants. Metal hypersensitivity is an important problem in orthopedics, because of its potential role in formation of pseudotumors, ,chronic pain, joint effusion and also prosthetic joint failure and revision need.

Metal hipersensitivitesi, özellikle nikel duyarlılığı, toplumda sık görülen bir tablodur. İmplante metaller biyolojik sıvılarla temas ettiğinde aşınır ve demir, krom, nikel, alüminyum ve molibden gibi metalik iyonlar salınır. Bu metal iyonları lokal veya sistemik etkilerle hipersensitivite reaksiyonlarına neden olabilir. İmplante materyale karşı gelişen cilt lezyonları primer olarak T hücre aracılı tip 4 gecikmiş tip hipersensitivite reaksiyonudur. Yama testi metal duyarlılığını göstermede altın standarttır. Rutin olarak operasyon öncesi yama testi önerilmemekte olup, hastanın öyküsünde kişisel metal duyarlılığı öyküsü var ise yapılmalıdır. Hastaların preoperatif değerlendirmesi sırasında kimin hipersensitivite reaksiyonu geliştireceğini önceden belirleyen bir test yöntemi yoktur. Metal hipersensitivitesi; psödotümör formasyonu, kronik ağrı, eklem efüzyonu ve hatta protez başarısızlığı ve değiştirilmesine neden olabileceğinden ortopedide önemli bir sorundur.
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Journal Section Reviews

Orcid: 0000-0001-8107-1561
Author: Fatma Düşünür Günsen (Primary Author)
Institution: Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve İmmünoloji Bilim Dalı
Country: Turkey

Orcid: 0000-0002-9199-1991
Author: Aytül Zerrin Sin
Institution: Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve İmmünoloji Bilim Dalı, İzmir
Country: Turkey

Orcid: 0000-0002-2149-3225
Author: Semih Aydoğdu
Institution: Ege Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı
Country: Turkey

Bibtex @review { etd530349, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {Ege University}, year = {2019}, volume = {58}, pages = {92 - 102}, doi = {10.19161/etd.530349}, title = {Metalik implantlar alerji yapar mı?}, key = {cite}, author = {Düşünür Günsen, Fatma and Sin, Aytül Zerrin and Aydoğdu, Semih} }
APA Düşünür Günsen, F , Sin, A , Aydoğdu, S . (2019). Metalik implantlar alerji yapar mı?. Ege Tıp Dergisi, 58 (1), 92-102. Retrieved from
MLA Düşünür Günsen, F , Sin, A , Aydoğdu, S . "Metalik implantlar alerji yapar mı?". Ege Tıp Dergisi 58 (2019): 92-102 <>
Chicago Düşünür Günsen, F , Sin, A , Aydoğdu, S . "Metalik implantlar alerji yapar mı?". Ege Tıp Dergisi 58 (2019): 92-102
RIS TY - JOUR T1 - Metalik implantlar alerji yapar mı? AU - Fatma Düşünür Günsen , Aytül Zerrin Sin , Semih Aydoğdu Y1 - 2019 PY - 2019 N1 - DO - T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 92 EP - 102 VL - 58 IS - 1 SN - 1016-9113-2147-6500 M3 - UR - Y2 - 2018 ER -
EndNote %0 Ege Journal of Medicine Metalik implantlar alerji yapar mı? %A Fatma Düşünür Günsen , Aytül Zerrin Sin , Semih Aydoğdu %T Metalik implantlar alerji yapar mı? %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 1 %R %U
ISNAD Düşünür Günsen, Fatma , Sin, Aytül Zerrin , Aydoğdu, Semih . "Metalik implantlar alerji yapar mı?". Ege Tıp Dergisi 58 / 1 (March 2019): 92-102.