Yıl 2018, Cilt 27, Sayı 3, Sayfalar 205 - 210 2018-12-25

ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE
AMİTRİPTİLİNİN FAREDEKİ ANTİDEPRESAN BENZERİ ETKİSİNİN ADENOZİN A2A RESEPTÖR ANTAGONİZMASI İLE ARTIŞI

Gülay SEZER [1]

1 16

Objective: The role of the endogenous adenosinergic system in the peripheral effect of an antidepressant drug, amitriptyline, has been demonstrated in pain models and also in cardiovascular toxicity induced by amitriptyline. We performed this study as there is no information on whether adenosine or adenosine A2A receptor antagonists have any effect on the antidepressant-like activity of amitriptyline in mice. Methods: Balb-c mice were used in experiments and forced swimming test was used to evaluate the antidepressant-like activity. Mice were injected with saline (control), amitriptyline, SCH 58261 (A2A receptor antagonist), SCH 58261 + amitriptyline, adenosine, adenosine + amitriptyline, intraperitoneally. Results: Amitriptyline decreased immobility time compared to control group at both doses. SCH 58261 did not produce antidepressant like effect in the applied dose alone. Pretreatment of amitriptyline with SCH 58261 produced stronger inhibition of immobility time than amitriptyline induced alone in the same dose. Coadministration of adenosine with amitriptyine, however, it was not decreased the anti-immobility effect of amitriptyline. However, it was not statistically significant. Conclusion: It has been demonstrated that adenosinergic system may have a role in the antidepressant-like activity of amitriptyline in mice, and pretreatment with the A2A receptor antagonist may induce a more pronounced antidepressant-like activity. We are of the opinion that this finding may be of particular importance in the case of drug resistant patients. 

Amaç: Antidepresan bir ilaç olan amitriptilinin periferal etkilerinde adenozinerjik sistemin rolü olduğu ağrı modellerinde ve amitriptilinin neden olduğu kardiyovasküler sistem toksisitesinde gösterilmiştir. Ancak amitripitilinin antidepresan aktivitesinde adenozin ya da adenozin A2A reseptör antagonismasının rolü olup olmadığına dair bilgi bulunmadığı için bu çalışmayı planladık. Metod: Deneylerde antidepresan benzeri etkiyi tayin için Balb-c fareler üzerinde zorunlu yüzme testi uygulanmıştır. Farelere serum fizyolojik (kontrol grubu), amitriptilin, SCH 58261 (A2A reseptör antagonisti), SCH 58261+amitriptilin, adenozin, adenozin+amitriptilin intraperitoneal yoldan uygulanmıştır. Bulgular: Amitriptilin her iki dozunda da kontrol grubuna göre hareketsiz kalma zamanını azaltmıştır. Amitriptilinin hareketsiz kalma süresini azaltıcı etkisi SCH 58261 ile ön muamele edildiğinde daha da artmıştır. Adenozin ile amitriptilin birlikte uygulandığında ise amitriptilinin hareketsiz kalma süresini azaltıcı etkisi azalmakla birlikte bu etki istatistiksel olarak anlamlı bulunmamıştır. Tartışma: Amitriptilinin faredeki antidepresan benzeri etkisinde adenozinerjik sistemin rolü olabileceği ve A2A receptor antagonisti ile ön muamele edildiğinde bu etkinin artabileceği gösterilmiştir. Bu bulgunun özellikle ilaca dirençli hastalarda önemli olabileceğini düşünmekteyiz.
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Yazar: Gülay SEZER (Sorumlu Yazar)
Kurum: ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Bibtex @araştırma makalesi { eujhs507596, journal = {Sağlık Bilimleri Dergisi}, issn = {1018-3655}, address = {Erciyes Üniversitesi}, year = {2018}, volume = {27}, pages = {205 - 210}, doi = {}, title = {ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE}, key = {cite}, author = {SEZER, Gülay} }
APA SEZER, G . (2018). ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE. Sağlık Bilimleri Dergisi, 27 (3), 205-210. Retrieved from http://dergipark.gov.tr/eujhs/issue/42158/507596
MLA SEZER, G . "ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE". Sağlık Bilimleri Dergisi 27 (2018): 205-210 <http://dergipark.gov.tr/eujhs/issue/42158/507596>
Chicago SEZER, G . "ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE". Sağlık Bilimleri Dergisi 27 (2018): 205-210
RIS TY - JOUR T1 - ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE AU - Gülay SEZER Y1 - 2018 PY - 2018 N1 - DO - T2 - Sağlık Bilimleri Dergisi JF - Journal JO - JOR SP - 205 EP - 210 VL - 27 IS - 3 SN - 1018-3655- M3 - UR - Y2 - 2018 ER -
EndNote %0 Sağlık Bilimleri Dergisi ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE %A Gülay SEZER %T ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE %D 2018 %J Sağlık Bilimleri Dergisi %P 1018-3655- %V 27 %N 3 %R %U
ISNAD SEZER, Gülay . "AMİTRİPTİLİNİN FAREDEKİ ANTİDEPRESAN BENZERİ ETKİSİNİN ADENOZİN A2A RESEPTÖR ANTAGONİZMASI İLE ARTIŞI". Sağlık Bilimleri Dergisi 27 / 3 (Aralık 2018): 205-210.