Yıl 2016, Cilt 2, Sayı 1, Sayfalar 46 - 51 2016-03-04

Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis

Ozlem Arican Ozluk [1] , Mustafa Yilmaz [2] , Dursun Topal [3] , Erhan Tenekecioglu [4] , Selcuk Kanat [5] , Fahriye Vatansever [6] , Tezcan Peker [7] , Kemal Karaagac [8] , Bedrettin Boyraz [9]

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Objectives. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the previous studies, left ventricle (LV) subclinical myocardial dysfunction was reported in the psoriasis patients. The T-wave peak to end (Tp-e) interval is a relatively new marker for ventricular arrhythmogenesis and repolarization heterogeneity. Prolongation of this interval represents a period of potential vulnerability to ventricular arrhythmias. However, there is no information available assessing the Tp-e interval and related calculations in patients with psoriasis disease. The aim of this study was to evaluate ventricular repolarization in patients with psoriasis disease by using QT, corrected QT (QTc) and Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Methods. In this study, retrospective analysis of 30 patients who underwent the psoriasis treatment and of 30 healthy individuals was performed. The severity of the disease was evaluated by the “Psoriasis Area and Severity Index”. QT, corrected QT (QTc), Tp-e interval and Tp-e/QT ratio were measured by means of the 12-lead electrocardiogram. Left ventricular function was evaluated by echocardiography. Results. Baseline characteristics and QT and QTc intervals were similar in both groups. No difference was detected between the groups with regards to Tp-e interval (83.0±9 vs 82.3±10; p=0.81), Tp-e/QT (0.22±0.03 vs 0.23±0.04; p=0.3) and Tp-Te/QTc (0.20±0.04 vs 0.19±0.04; p=0.77). Conclusions. These findings suggest that ventricular repolarization in mild to moderate psoriasis patients might be unimpaired. Larger samples and severe degree psoriasis patients are needed to evaluate the arrhythmia risk in psoriasis patients.

Psoriasis, Tp-Te interval; Tp-Te/QT ratio
  • Parisi R, Symmons DP, Griffiths CE, Ashcroft DM, Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013 Feb;133(2):377-85.
  • Tseng HW, Lin HS, Lam HC. Co-morbidities in psoriasis: a hospital-based case-control study. J Eur Acad Dermatol Venereol. 2013 Nov;27(11):1417-25.
  • Ryan C, Menter A. Psoriasis and cardiovascular disorders. G Ital Dermatol Venereol. 2012 Apr;147(2):179-87.
  • Armstrong AW, Schupp C, Bebo B. Psoriasis comorbidities: results from the National Psoriasis Foundation surveys 2003 to 2011. Dermatology. 2012;225(2):121-6.
  • Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J. 2010 Apr;31(8):1000-6.
  • Shang Q, Tam LS, Yip GW, Sanderson JE, Zhang Q, Li EK, et al. High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis. J Rheumatol. 2011 Jul;38(7):1363-70.
  • Shang Q, Tam LS, Sanderson JE, Sun JP, Li EK, Yu CM. Increase in ventricular-arterial stiffness in patients with psoriatic arthritis. Rheumatology (Oxford). 2012 Dec;51(12):2215-23.
  • Zhao CT, Yeung CK, Siu CW, Tam S, Chan J, Chen Y, et al. Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. J Eur Acad Dermatol Venereol. 2014 Apr;28(4):461-8.
  • Smetana P, Schmidt A, Zabel M, Hnatkova K, Franz M, Huber, et al. Assessment of repolarization heterogeneity for prediction of mortality in cardiovascular disease: peak to the end of the T wave interval and nondipolar repolarization components. J Electrocardiol. 2011 May-Jun;44 (3):301-8.
  • Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008 Nov-Dec;41(6):567-74.
  • Louden BA, Pearce DJ, Lang W, Feldman SR. A Simplified Psoriasis Area Severity Index (SPASI) for rating psoriasis severity in clinic patients. Dermatol Online J. 2004 Oct 15;10(2):7.
  • Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ermande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update form the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70.
  • Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, Dorantes Sánchez M, Dorticós Balea F, Zayas Molina R, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol. 2006 May 2;47(9):1828-34.
  • Schön MP, Boehncke WH. Psoriasis. N Engl J Med. 2005 May 5;352(18):1899-912.
  • Fridewald VE Jr, Cather JC, Gordon KB, Kavanaugh A, Ridker PM, Roberts WC. The editor’s roundtable: psoriasis, inflammation and coronary artery disease. Am J Cardiol. 2008 Apr 15;101(8):1119-26.
  • Kremers HM, McEvoy MT, Dann FJ, Gabriel SE. Heart disease in psoriasis. J Am Acad Dermatol. 2007 Aug;57(2):347-54.
  • Simsek H, Sahin M, Akyol A, Akdag S, Ozkul HU, Gumrukcuoglu HA, et al. Increased risk of atrial and ventricular arrhythmia in long-lasting psoriasis patients. ScientificWorldJournal. 2013 Apr 3;2013:901215.
  • Calapkorur B, Kelesoglu S, Sarli B, Turasan A, Arinc H, Kaya MG. Atrial electromechanical delay is impaired in patients with psoriasis. Med Princ Pract. 2015;24(1):30-5.
  • Liu T, Li G. Is atrial fibrillation an inflammatory disease? Medical Hypotheses. 2005;64(6):1237-8.
  • Liu T, Li G, Li L, Korantzopoulos P. Association between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysis. J Am Coll Cardiol. 2007 Apr 17;49(15):1642-8.
  • Korantzopoulos P, Kolettis TM, Galaris D, Goudevenos JA. The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int J Cardiol. 2007 Feb 7;115(2):135-43.
  • Kowalewski M, Urban M, Mroczko B, Szmitkowski M. [Proinflammatory cytokines (IL-6, TNF-alpha) and cardiac troponin I (cTnI) in serum of young people with ventricular arrhythmias]. Pol Arch Med Wewn. 2002 Jul;108(1):647-51. [Article in Polish]
  • Proietti I, Raimondi G, Skroza N, Pampena R, Bernardini N, La Viola G, et al. Cardiovascular risk in psoriatic patients detected by heart rate variability (HRV) analysis. Drug Dev Res. 2014 Nov;75 Suppl 1:S81-4.
  • Kors JA, Ritsema van Eck HJ, van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. J Electrocardiol. 2008 Nov-Dec;41(6):575-80.
  • Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W, et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007 Aug;4(8):1114-6; author reply 1116-9.
  • Maradit-Kremers H, Icen M, Ernste FC, Dierkhising RA, McEvoy MT. Disease severity and therapy as predictors of cardiovascular risk in psoriasis: a population-based cohort study. J Eur Acad Dermatol Venereol. 2012 Mar; 26(3):336-43.
  • Radtke MA, Langenbruch AK, Schäfer I, Herberger K, Reich K, Augustin M. Nail psoriasis as a severity indicator: results from the PsoReal study. Patient Relat Outcome Meas. 2011 Jul:2:1-6.
Konular Sağlık Bilimleri ve Hizmetleri
Dergi Bölümü Original Article
Yazarlar

Yazar: Ozlem Arican Ozluk
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Mustafa Yilmaz
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Dursun Topal
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Erhan Tenekecioglu
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Selcuk Kanat
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Fahriye Vatansever
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Tezcan Peker
Kurum: Department of Cardiology, Bursa Doruk Hospital, Bursa
Ülke: Turkey


Yazar: Kemal Karaagac
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Yazar: Bedrettin Boyraz
Kurum: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Ülke: Turkey


Bibtex @araştırma makalesi { eurj260412, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2016}, volume = {2}, pages = {46 - 51}, doi = {10.18621/eurj.2016.2.1.46}, title = {Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis}, key = {cite}, author = {Peker, Tezcan and Kanat, Selcuk and Arican Ozluk, Ozlem and Yilmaz, Mustafa and Karaagac, Kemal and Vatansever, Fahriye and Tenekecioglu, Erhan and Topal, Dursun and Boyraz, Bedrettin} }
APA Arican Ozluk, O , Yilmaz, M , Topal, D , Tenekecioglu, E , Kanat, S , Vatansever, F , Peker, T , Karaagac, K , Boyraz, B . (2016). Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis. The European Research Journal, 2 (1), 46-51. DOI: 10.18621/eurj.2016.2.1.46
MLA Arican Ozluk, O , Yilmaz, M , Topal, D , Tenekecioglu, E , Kanat, S , Vatansever, F , Peker, T , Karaagac, K , Boyraz, B . "Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis". The European Research Journal 2 (2016): 46-51 <http://dergipark.gov.tr/eurj/issue/24599/260412>
Chicago Arican Ozluk, O , Yilmaz, M , Topal, D , Tenekecioglu, E , Kanat, S , Vatansever, F , Peker, T , Karaagac, K , Boyraz, B . "Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis". The European Research Journal 2 (2016): 46-51
RIS TY - JOUR T1 - Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis AU - Ozlem Arican Ozluk , Mustafa Yilmaz , Dursun Topal , Erhan Tenekecioglu , Selcuk Kanat , Fahriye Vatansever , Tezcan Peker , Kemal Karaagac , Bedrettin Boyraz Y1 - 2016 PY - 2016 N1 - doi: 10.18621/eurj.2016.2.1.46 DO - 10.18621/eurj.2016.2.1.46 T2 - The European Research Journal JF - Journal JO - JOR SP - 46 EP - 51 VL - 2 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.2016.2.1.46 UR - http://dx.doi.org/10.18621/eurj.2016.2.1.46 Y2 - 2018 ER -
EndNote %0 The European Research Journal Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis %A Ozlem Arican Ozluk , Mustafa Yilmaz , Dursun Topal , Erhan Tenekecioglu , Selcuk Kanat , Fahriye Vatansever , Tezcan Peker , Kemal Karaagac , Bedrettin Boyraz %T Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis %D 2016 %J The European Research Journal %P -2149-3189 %V 2 %N 1 %R doi: 10.18621/eurj.2016.2.1.46 %U 10.18621/eurj.2016.2.1.46
ISNAD Arican Ozluk, Ozlem , Yilmaz, Mustafa , Topal, Dursun , Tenekecioglu, Erhan , Kanat, Selcuk , Vatansever, Fahriye , Peker, Tezcan , Karaagac, Kemal , Boyraz, Bedrettin . "Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis". The European Research Journal 2 / 1 (Mart 2016): 46-51. http://dx.doi.org/10.18621/eurj.2016.2.1.46