Cilt 3, Sayı 1, Sayfalar 11 - 15 2017-03-04

Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

Sedat Dogan [1] , Hasmet Yazici [2] , Esin Yalcinkaya [3] , Halil Ibrahim Erdogdu [4]

506 146

Objective. The aim of the present study was to investigate the protective role of selenium against cisplatin-induced oral mucositis in rats. Methods. Healthy wistar albino rats (n=21) were randomly divided into three groups: Cisplatin (Cis), cisplatin and selenium (Cis+Se) and control (C). Cisplatin was administered for 3 days to Cis and Cis+Se groups. Cis+Se group received selenium 5 days before cisplatin injection and continued for 11 consecutive days. Malondialdehyde (MDA) levels of the rats were determined before and at the end of experimental protocol. The tongues of rats were harvested for immunuhistochemical examinations. Results. In biochemichal analysis, MDA levels significantly increased in the Cis group (p=0.018). On the contrary, there was no significant difference between pretreatment and posttreatment MDA levels in Cis+Se group (p=0.128). In the immunohistochemical examinations of lingual tissues stained with anti-caspase-3, when the Cis and Cis+Se groups were compared, there were significantly more immunopositivity in the Cis group and significantly less immunopositivity in the Cis+Se group (p<0.05). Conclusions. Selenium might have played a protective role against cisplatin-induced oral mucositis in rats. Further studies are necessary before its clinical use in patients.

Cisplatin,oral mucositis; selenium; toxicity
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Konular Sağlık Bilimleri
Dergi Bölümü Original Article
Yazarlar

Yazar: Sedat Dogan
E-posta: sdtdgn1981@hotmail.com

Yazar: Hasmet Yazici
E-posta: hsmtyzc@yahoo.com

Yazar: Esin Yalcinkaya
E-posta: esinkbbesin@gmail.com

Yazar: Halil Ibrahim Erdogdu
E-posta: ibrahimhalilerdogdu@gmail.com

Bibtex @araştırma makalesi { eurj262881, journal = {The European Research Journal}, issn = {}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2017}, volume = {3}, pages = {11 - 15}, doi = {10.18621/eurj.2016.5000202107}, title = {Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats}, language = {en}, key = {cite}, author = {Dogan, Sedat and Yazici, Hasmet and Erdogdu, Halil Ibrahim and Yalcinkaya, Esin} }
APA Dogan, S , Yazici, H , Yalcinkaya, E , Erdogdu, H . (2017). Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats. The European Research Journal, 3 (1), 11-15. DOI: 10.18621/eurj.2016.5000202107
MLA Dogan, S , Yazici, H , Yalcinkaya, E , Erdogdu, H . "Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats". The European Research Journal 3 (2017): 11-15 <http://dergipark.gov.tr/eurj/issue/27747/262881>
Chicago Dogan, S , Yazici, H , Yalcinkaya, E , Erdogdu, H . "Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats". The European Research Journal 3 (2017): 11-15
RIS TY - JOUR T1 - Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats AU - Sedat Dogan , Hasmet Yazici , Esin Yalcinkaya , Halil Ibrahim Erdogdu Y1 - 2017 PY - 2017 N1 - doi: 10.18621/eurj.2016.5000202107 DO - 10.18621/eurj.2016.5000202107 T2 - The European Research Journal JF - Journal JO - JOR SP - 11 EP - 15 VL - 3 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.2016.5000202107 UR - http://dx.doi.org/10.18621/eurj.2016.5000202107 Y2 - 2016 ER -
EndNote %0 The European Research Journal Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats %A Sedat Dogan , Hasmet Yazici , Esin Yalcinkaya , Halil Ibrahim Erdogdu %T Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats %D 2017 %J The European Research Journal %P -2149-3189 %V 3 %N 1 %R doi: 10.18621/eurj.2016.5000202107 %U 10.18621/eurj.2016.5000202107