Yıl 2017, Cilt 3, Sayı 2, Sayfalar 118 - 126 2017-02-28

Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids

Utku Kursat Ercan [1] , Fatma Ibis [2]

385 402

Objectives. Antimicrobial activities of non-thermal atmospheric plasma-treated liquids on various bacterial and fungal strains in their planktonic and biofilm forms have been widely reported. Since most of the plasma-treated liquids are water based, they might be washed off certain surfaces and they cannot be applied for the infections of respiratory tract. In the present study we have tested antimicrobial activities of plasma-treated N-acetyl cysteine solution (NAC), phosphate buffered saline (PBS) solution and deionized water when nebulized over planktonic forms of E. coli and S. aureus. Methods. Antimicrobial activities of nebulized plasma-treated liquids were evaluated with zone of inhibition test and colony counting assay. Moreover pH of NAC, PBS solution and deionized water were measured before, after plasma treatment and during nebulization since low pH is well known consequence observed in plasma-treated liquids. Results. Our results have revealed that pH of plasma-treated NAC, PBS solution and DIW decreases after plasma treatment consistent with previous reports and does not change during nebulization. Moreover, antimicrobial activity assessment indicates that nebulized plasma-treated NAC shows the strongest antimicrobial activity, which leads complete inactivation of bacteria for 103 to 106 CFU/ml initial bacterial load and 5-log reduction for 107 CFU/ml initial bacterial load on both E. coli and S. aureus. Conclusions. Plasma-treated liquids could retain their antimicrobial activity during nebulization and nebulization could be considered as a future alternative method for delivery of plasma-treated liquids for respiratory tract infections. 

Non-thermal plasma, plasma medicine, nebulization, antimicrobial, biomedical engineering
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Konular Sağlık Bilimleri
Dergi Bölümü Original Article

Yazar: Utku Kursat Ercan
Kurum: Department of Biomedical Engineering, Izmir Katip Celebi University, Izmir
Ülke: Turkey

Yazar: Fatma Ibis
Kurum: Department of Biomedical Engineering, Izmir Katip Celebi University, Izmir
Ülke: Turkey

Bibtex @araştırma makalesi { eurj268572, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2017}, volume = {3}, pages = {118 - 126}, doi = {10.18621/eurj.268572}, title = {Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids}, key = {cite}, author = {Ercan, Utku Kursat and Ibis, Fatma} }
APA Ercan, U , Ibis, F . (2017). Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids. The European Research Journal, 3 (2), 118-126. DOI: 10.18621/eurj.268572
MLA Ercan, U , Ibis, F . "Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids". The European Research Journal 3 (2017): 118-126 <http://dergipark.gov.tr/eurj/issue/29661/268572>
Chicago Ercan, U , Ibis, F . "Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids". The European Research Journal 3 (2017): 118-126
RIS TY - JOUR T1 - Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids AU - Utku Kursat Ercan , Fatma Ibis Y1 - 2017 PY - 2017 N1 - doi: 10.18621/eurj.268572 DO - 10.18621/eurj.268572 T2 - The European Research Journal JF - Journal JO - JOR SP - 118 EP - 126 VL - 3 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.268572 UR - http://dx.doi.org/10.18621/eurj.268572 Y2 - 2017 ER -
EndNote %0 The European Research Journal Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids %A Utku Kursat Ercan , Fatma Ibis %T Bactericidal efficacies of nebulized non-thermal atmospheric plasma-treated liquids %D 2017 %J The European Research Journal %P -2149-3189 %V 3 %N 2 %R doi: 10.18621/eurj.268572 %U 10.18621/eurj.268572