Cilt 3, Sayı 2, Sayfalar 135 - 139 2017-03-07

Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients

Nurettin Ay [1] , Melih Anil [2] , Vahhac Alp [3] , Safak Kaya [4] , Neslihan Cicek [5] , Ozgur Arslan [6]

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Objectives. Procalcitonin is a propeptide of calcitonin and has been increasingly used as a biomarker of infection. The aim of this study was to evaluate correlation of serum C-reactive protein (CRP) and procalcitonin (PCT) levels of kidney transplant patients hospitalized due to infection. Methods. There were 121 patients who had kidney transplant in our center between September 2012 and February 2017 and patients with a diagnosis of infection or rejection were included in the study. Simultaneous 106 serum CRP and PCT levels at the beginning or during any time of treatment for post-transplant infection, cytomegalovirus (CMV) positivity, BK viremia and rejection were evaluated. Results. Median and interquartile ranges of CRP and PCT serum levels were 40 mg/l [24.7-64.9] and 0.19 ng/ml [0.1-0.61], respectively. A significant positive correlation between serum CRP and PCT levels of the patients were observed (r=0.490, p<0.001). When serum CRP levels were grouped as <50 mg/l, 50-100 mg/l and >100 mg/l, correlations with serum PCT levels were as r=0.461 (p<0.001), r=-0.52 (p=0.860) and r=0.488 (p=0.153), respectively. Serum levels of PCT did not increase in CMV and BK virus infections and rejection. Conclusions. Serum CRP and PCT levels were correlated as a whole in the study, whereas serum CRP levels of 50-100 mg/l and >100 mg/l did not show a statistically significant correlation. Stability of PCT levels in viral infections and rejections might be an advantage for the follow-up of solid organ transplants. We need prospective trials of PCT measurements for the evaluation of post-transplant infections. 

C-reactive protein,procalcitonin,correlation,kidney transplantation
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Konular Sağlık Bilimleri
Dergi Bölümü Original Article
Yazarlar

Yazar: Nurettin Ay
E-posta: nurettinay77@hotmail.com
Kurum: DIYARBAKIR EAH
Ülke: Turkey


Yazar: Melih Anil
E-posta: melihanil@hotmail.com
Kurum: DIYARBAKIR EAH
Ülke: Turkey


Yazar: Vahhac Alp
E-posta: vahhacalp@gmail.com
Kurum: DIYARBAKIR EAH
Ülke: Turkey


Yazar: Safak Kaya
E-posta: ksafak76@gmail.com
Kurum: DIYARBAKIR EAH
Ülke: Turkey


Yazar: Neslihan Cicek
E-posta: drneslihancicek@yahoo.com
Kurum: Department of Pediatric Nephrology, Transplantation Center, University of Health Sciences, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir
Ülke: Turkey


Yazar: Ozgur Arslan
E-posta: ozgurarslan44@yahoo.com
Kurum: DIYARBAKIR EAH
Ülke: Turkey


Bibtex @araştırma makalesi { eurj291746, journal = {The European Research Journal}, issn = {}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2017}, volume = {3}, pages = {135 - 139}, doi = {10.18621/eurj.291746}, title = {Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients}, language = {en}, key = {cite}, author = {Alp, Vahhac and Kaya, Safak and Arslan, Ozgur and Ay, Nurettin and Cicek, Neslihan and Anil, Melih} }
APA Ay, N , Anil, M , Alp, V , Kaya, S , Cicek, N , Arslan, O . (2017). Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients. The European Research Journal, 3 (2), 135-139. DOI: 10.18621/eurj.291746
MLA Ay, N , Anil, M , Alp, V , Kaya, S , Cicek, N , Arslan, O . "Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients". The European Research Journal 3 (2017): 135-139 <http://dergipark.gov.tr/eurj/issue/29661/291746>
Chicago Ay, N , Anil, M , Alp, V , Kaya, S , Cicek, N , Arslan, O . "Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients". The European Research Journal 3 (2017): 135-139
RIS TY - JOUR T1 - Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients AU - Nurettin Ay , Melih Anil , Vahhac Alp , Safak Kaya , Neslihan Cicek , Ozgur Arslan Y1 - 2017 PY - 2017 N1 - doi: 10.18621/eurj.291746 DO - 10.18621/eurj.291746 T2 - The European Research Journal JF - Journal JO - JOR SP - 135 EP - 139 VL - 3 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.291746 UR - http://dx.doi.org/10.18621/eurj.291746 Y2 - 2017 ER -
EndNote %0 The European Research Journal Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients %A Nurettin Ay , Melih Anil , Vahhac Alp , Safak Kaya , Neslihan Cicek , Ozgur Arslan %T Correlation of serum C-reactive protein and procalcitonin levels in infections of kidney transplant recipients %D 2017 %J The European Research Journal %P -2149-3189 %V 3 %N 2 %R doi: 10.18621/eurj.291746 %U 10.18621/eurj.291746