Yıl 2018, Cilt 4, Sayı 1, Sayfalar 38 - 43 2018-01-04

Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Ayca Ant [1] , Erdogan Inal [2] , Aslihan Avci [3] , Metin Genc [4] , Umit Tuncel [5] , Ziya Sencan [6] , Yasemin Genc [7]

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Objective. Inflammation and oxidative stress are considered as the main pathways in oral cavity carcinoma. The aim of this study was to evaluate the activity levels of adenosine deaminase (ADA), nitric oxide (NO), nitric oxide synthase (NOS), and xanthine oxidase (XO) in oral cavity carcinoma, to determine their potential roles in carcinogenesis with relation to oxidative stress. Methods. Seventeen patients with oral cavity cancer underwent surgery as the primary therapy, were consisted in the study. Resected oral cavity carcinoma tissues were compared with the adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO activity levels were evaluated in terms of difference. Results. There is a significant increase of ADA activity in squamous cell cancer tissues, which indicates a difference between the normal and tumor tissues at enzyme levels (p<0.001). Conclusion. Elevated ADA activity might be an attempt to supress formation of the immunosupressed niche which promotes the onset of neoplasia and/or to inhibit tumor progression and metastasis. 

Adenosine deaminase, nitric oxide, nitric oxide synthase, oral cancer, oxidative stress, xanthine oxidase
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Konular Sağlık Bilimleri ve Hizmetleri
Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0002-9469-1468
Yazar: Ayca Ant
Kurum: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Ülke: Turkey


Yazar: Erdogan Inal
Kurum: Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara
Ülke: Turkey


Yazar: Aslihan Avci
Kurum: Department of Biochemistry, Ankara University School of Medicine, Ankara
Ülke: Turkey


Yazar: Metin Genc
Kurum: Department of Biochemistry, Ankara University School of Medicine, Ankara
Ülke: Turkey


Yazar: Umit Tuncel
Kurum: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Ülke: Turkey


Yazar: Ziya Sencan
Kurum: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Ülke: Turkey


Yazar: Yasemin Genc
Kurum: Department of Biostatistics, Ankara University School of Medicine, Ankara
Ülke: Turkey


Bibtex @araştırma makalesi { eurj322520, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2018}, volume = {4}, pages = {38 - 43}, doi = {10.18621/eurj.322520}, title = {Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer}, key = {cite}, author = {Sencan, Ziya and Genc, Yasemin and Tuncel, Umit and Genc, Metin and Inal, Erdogan and Ant, Ayca and Avci, Aslihan} }
APA Ant, A , Inal, E , Avci, A , Genc, M , Tuncel, U , Sencan, Z , Genc, Y . (2018). Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer. The European Research Journal, 4 (1), 38-43. DOI: 10.18621/eurj.322520
MLA Ant, A , Inal, E , Avci, A , Genc, M , Tuncel, U , Sencan, Z , Genc, Y . "Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer". The European Research Journal 4 (2018): 38-43 <http://dergipark.gov.tr/eurj/issue/32896/322520>
Chicago Ant, A , Inal, E , Avci, A , Genc, M , Tuncel, U , Sencan, Z , Genc, Y . "Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer". The European Research Journal 4 (2018): 38-43
RIS TY - JOUR T1 - Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer AU - Ayca Ant , Erdogan Inal , Aslihan Avci , Metin Genc , Umit Tuncel , Ziya Sencan , Yasemin Genc Y1 - 2018 PY - 2018 N1 - doi: 10.18621/eurj.322520 DO - 10.18621/eurj.322520 T2 - The European Research Journal JF - Journal JO - JOR SP - 38 EP - 43 VL - 4 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.322520 UR - http://dx.doi.org/10.18621/eurj.322520 Y2 - 2017 ER -
EndNote %0 The European Research Journal Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer %A Ayca Ant , Erdogan Inal , Aslihan Avci , Metin Genc , Umit Tuncel , Ziya Sencan , Yasemin Genc %T Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer %D 2018 %J The European Research Journal %P -2149-3189 %V 4 %N 1 %R doi: 10.18621/eurj.322520 %U 10.18621/eurj.322520
ISNAD Ant, Ayca , Inal, Erdogan , Avci, Aslihan , Genc, Metin , Tuncel, Umit , Sencan, Ziya , Genc, Yasemin . "Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer". The European Research Journal 4 / 1 (Ocak 2018): 38-43. http://dx.doi.org/10.18621/eurj.322520