Cilt 4, Sayı 1, Sayfalar 32 - 37 2018-01-04

The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome

Nefise Tanrıdan Okcu [1] , Hakan Nazik [2] , Ayşe Topcu Akduman [3] , Gürkan Uncu [4]

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Objective. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting up to 10% of reproductive-age women. Anti-Mullerian hormone (AMH) is a member of the transforming growth factor β family and has an inhibitory effect on primordial follicle recruitment in the ovary. The study aimed to investigate the importance of serum AMH levels in the different phenotypes of PCOS and find the optimal cut-off level of AMH in PCOS patients. Methods. This was a prospective clinical trial in which diagnoses of 50 PCOS patients based on Rotterdam revised criteria were compared to 50 normo-ovulatory cases. Additionally, the PCOS group was divided into 2 subgroups based on 2 or 3 Rotterdam criteria and compared to 50 normo-ovulatory cases. Results. When compared with the control group, the AMH levels of the PCOS group were significantly higher than those of the control group (6.81 ± 2.8 ng/ml vs. 3.22 ± 2.2 ng/ml, p < 0.001). In the subgroup analysis, the AMH levels of Group 1 and Group 2 were significantly higher than those of the control group (p < 0.001). The AMH cut-off value of 4.1 ng/ml was found to distinguish healthy women from PCOS patients, with 84% sensitivity and 80% specificity. Conclusions. Subgroup analyses showed higher levels of AMH in the severe PCOS group, but the difference was not statistically significant. More studies are suggested for researching the different PCOS subgroups to detect optimal AMH thresholds.

anti-Mullerian hormone,ovarian follicles,polycystic ovary syndrome,ultrasonography
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Konular Sağlık Bilimleri
Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0003-2307-7628
Yazar: Nefise Tanrıdan Okcu
E-posta: nefise-tanridan@hotmail.com
Kurum: Department of Obstetrics and Gynecology, University of Health Sciences, Adana Numune Training and Research Hospital, Adana
Ülke: Turkey


Orcid: 0000-0001-6495-3511
Yazar: Hakan Nazik
E-posta: drhakannazik@gmail.com
Kurum: Department of Obstetrics and Gynecology, University of Health Sciences, Adana Numune Training and Research Hospital, Adana
Ülke: Turkey


Yazar: Ayşe Topcu Akduman
E-posta: drayse58@gmail.com
Kurum: Department of Obstetrics and Gynecology, Düzce Atatürk State Hospital, Düzce
Ülke: Turkey


Yazar: Gürkan Uncu
E-posta: guncu@guncu.org
Kurum: Department of Obstetrics and Gynecology, Uludağ University School of Medicine, Bursa
Ülke: Turkey


Bibtex @araştırma makalesi { eurj332118, journal = {The European Research Journal}, issn = {}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2018}, volume = {4}, pages = {32 - 37}, doi = {10.18621/eurj.332118}, title = {The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome}, language = {en}, key = {cite}, author = {Tanrıdan Okcu, Nefise and Nazik, Hakan and Uncu, Gürkan and Topcu Akduman, Ayşe} }
APA Tanrıdan Okcu, N , Nazik, H , Topcu Akduman, A , Uncu, G . (2018). The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome. The European Research Journal, 4 (1), 32-37. DOI: 10.18621/eurj.332118
MLA Tanrıdan Okcu, N , Nazik, H , Topcu Akduman, A , Uncu, G . "The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome". The European Research Journal 4 (2018): 32-37 <http://dergipark.gov.tr/eurj/issue/32896/332118>
Chicago Tanrıdan Okcu, N , Nazik, H , Topcu Akduman, A , Uncu, G . "The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome". The European Research Journal 4 (2018): 32-37
RIS TY - JOUR T1 - The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome AU - Nefise Tanrıdan Okcu , Hakan Nazik , Ayşe Topcu Akduman , Gürkan Uncu Y1 - 2018 PY - 2018 N1 - doi: 10.18621/eurj.332118 DO - 10.18621/eurj.332118 T2 - The European Research Journal JF - Journal JO - JOR SP - 32 EP - 37 VL - 4 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.332118 UR - http://dx.doi.org/10.18621/eurj.332118 Y2 - 2017 ER -
EndNote %0 The European Research Journal The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome %A Nefise Tanrıdan Okcu , Hakan Nazik , Ayşe Topcu Akduman , Gürkan Uncu %T The relation between serum anti-Mullerian hormone levels and follicle count in polycystic ovary syndrome %D 2018 %J The European Research Journal %P -2149-3189 %V 4 %N 1 %R doi: 10.18621/eurj.332118 %U 10.18621/eurj.332118