Yıl 2018, Cilt 4, Sayı 2, Sayfalar 106 - 111 2018-04-04

The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

Betül Sargın [1] , Ayla Akbal [2] , Hatice Resorlu [3] , Yılmaz Savaş [4] , Coşkun Zateri [5] , Fatma Sılan [6] , Öztürk Özdemir [7]

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Objectives. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and its relationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one AS patients (25 male/16 female) fullfilling the 1984 Modified New York Criteria and 41 healthy controls (25 male/16 female) were included in this study. Disease activity of the AS patients was assesed by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthy controls were analyzed by Real-Time Polymerase Chain Reaction (PCR) System. Results. Three (7.3%) patients with AS had TLR4 gene polymorphism compared with healthy controls (0/41; 0%). Two of these patients had heterozygous mutation and one had homozygous mutation. Significant correlation was not found between TLR4 gene polymorphism and BASDAI score (p > 0.05). Conclusions. In our study, TLR4 gene polymorphism was higher in patients with AS compared with control group. But, this polymorphism was not associated with disease activity, erythrocyte sedimentation rate and C-reactive protein levels.

Ankylosing spondylitis, disease activity, mutation, polymorphism, toll-like receptor 4
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Dergi Bölümü Original Article
Yazarlar

Yazar: Betül Sargın
Kurum: Department of Physical Therapy and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Ayla Akbal
Kurum: Department of Physical Therapy and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Hatice Resorlu
Kurum: Department of Physical Therapy and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Yılmaz Savaş
Kurum: Department of Physical Therapy and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Coşkun Zateri
Kurum: Department of Physical Therapy and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Fatma Sılan
Kurum: Department of Medical Genetics, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Yazar: Öztürk Özdemir
Kurum: Department of Medical Genetics, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale
Ülke: Turkey


Bibtex @araştırma makalesi { eurj346968, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2018}, volume = {4}, pages = {106 - 111}, doi = {10.18621/eurj.346968}, title = {The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity}, key = {cite}, author = {Özdemir, Öztürk and Savaş, Yılmaz and Resorlu, Hatice and Sılan, Fatma and Zateri, Coşkun and Sargın, Betül and Akbal, Ayla} }
APA Sargın, B , Akbal, A , Resorlu, H , Savaş, Y , Zateri, C , Sılan, F , Özdemir, Ö . (2018). The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity. The European Research Journal, 4 (2), 106-111. DOI: 10.18621/eurj.346968
MLA Sargın, B , Akbal, A , Resorlu, H , Savaş, Y , Zateri, C , Sılan, F , Özdemir, Ö . "The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity". The European Research Journal 4 (2018): 106-111 <http://dergipark.gov.tr/eurj/issue/32986/346968>
Chicago Sargın, B , Akbal, A , Resorlu, H , Savaş, Y , Zateri, C , Sılan, F , Özdemir, Ö . "The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity". The European Research Journal 4 (2018): 106-111
RIS TY - JOUR T1 - The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity AU - Betül Sargın , Ayla Akbal , Hatice Resorlu , Yılmaz Savaş , Coşkun Zateri , Fatma Sılan , Öztürk Özdemir Y1 - 2018 PY - 2018 N1 - doi: 10.18621/eurj.346968 DO - 10.18621/eurj.346968 T2 - The European Research Journal JF - Journal JO - JOR SP - 106 EP - 111 VL - 4 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.346968 UR - http://dx.doi.org/10.18621/eurj.346968 Y2 - 2017 ER -
EndNote %0 The European Research Journal The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity %A Betül Sargın , Ayla Akbal , Hatice Resorlu , Yılmaz Savaş , Coşkun Zateri , Fatma Sılan , Öztürk Özdemir %T The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity %D 2018 %J The European Research Journal %P -2149-3189 %V 4 %N 2 %R doi: 10.18621/eurj.346968 %U 10.18621/eurj.346968
ISNAD Sargın, Betül , Akbal, Ayla , Resorlu, Hatice , Savaş, Yılmaz , Zateri, Coşkun , Sılan, Fatma , Özdemir, Öztürk . "The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity". The European Research Journal 4 / 2 (Nisan 2018): 106-111. http://dx.doi.org/10.18621/eurj.346968