Yıl 2019, Cilt 5, Sayı 1, Sayfalar 104 - 108 2019-01-04

Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs

Betül Sargın [1] , Gülcan Gürer [2] , Gülnur Taşcı Bozbaş [3] , Hakan Öztürk [4]

90 198

Objectives: Uric acid has an important role in the production of various inflammatory cytokines such as tumor necrosis factor-α (TNF-α). Although serum uric acid levels in various rheumatic diseases have been performed the relationships between serum uric acid levels with inflammatory markers and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores in ankylosing spondylitis patients treated with anti-TNF-α and nonsteroid anti-inflammatory drugs (NSAIDs) have not been described yet. The aim of this study was to compare the relationships between serum uric acid levels, inflammatory markers and BASDAI scores in ankylosing spondylitis patients treated anti-TNF-α and NSAIDs.

Methods: A total of 132 ankylosing spondylitis patients fulfilling the 1984 Modified New York Criteria who had serum uric acid, erythrocyte sedimentation rate and C-reactive protein levels in medical records were included in this retrospective cross-sectional study. Patients were divided in two groups (anti-TNF-α and NSAIDs). Their files were examined in detail. Later demographic and laboratory features were recorded to the research form.

Results: Serum uric acid levels were significantly lower in the anti-TNF-α group (mean: 4.9 mg/dL, range: 4.10-5.45 mg/dL) than in the NSAIDs group (mean: 5.20 mg/dL, range 4.70-5.90 mg/dL) (p = 0.021). Also, positive correlations were found between C-reactive protein (p = 0.003) and BASDAI (p = 0.009) with serum uric acid.

Conclusions: According to this  study, we can consider that serum uric acid level could be used as an inflammatory laboratory marker, such as C-reactive protein in ankylosing spondylitis patients. However, we believe that more studies are needed about this research. 

Uric acid, inflammation, ankylosing spondylitis
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Yazarlar

Orcid: 0000-0002-9463-8413
Yazar: Betül Sargın (Sorumlu Yazar)
Kurum: Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0002-4012-6180
Yazar: Gülcan Gürer
Kurum: Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0002-2476-0755
Yazar: Gülnur Taşcı Bozbaş
Kurum: Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0001-8112-4934
Yazar: Hakan Öztürk
Kurum: Department of Biostatistics, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj359504, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {104 - 108}, doi = {10.18621/eurj.359504}, title = {Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs}, key = {cite}, author = {Öztürk, Hakan and Taşcı Bozbaş, Gülnur and Gürer, Gülcan and Sargın, Betül} }
APA Sargın, B , Gürer, G , Taşcı Bozbaş, G , Öztürk, H . (2019). Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs. The European Research Journal, 5 (1), 104-108. DOI: 10.18621/eurj.359504
MLA Sargın, B , Gürer, G , Taşcı Bozbaş, G , Öztürk, H . "Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs". The European Research Journal 5 (2019): 104-108 <http://dergipark.gov.tr/eurj/issue/40357/359504>
Chicago Sargın, B , Gürer, G , Taşcı Bozbaş, G , Öztürk, H . "Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs". The European Research Journal 5 (2019): 104-108
RIS TY - JOUR T1 - Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs AU - Betül Sargın , Gülcan Gürer , Gülnur Taşcı Bozbaş , Hakan Öztürk Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.359504 DO - 10.18621/eurj.359504 T2 - The European Research Journal JF - Journal JO - JOR SP - 104 EP - 108 VL - 5 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.359504 UR - http://dx.doi.org/10.18621/eurj.359504 Y2 - 2018 ER -
EndNote %0 The European Research Journal Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs %A Betül Sargın , Gülcan Gürer , Gülnur Taşcı Bozbaş , Hakan Öztürk %T Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 1 %R doi: 10.18621/eurj.359504 %U 10.18621/eurj.359504
ISNAD Sargın, Betül , Gürer, Gülcan , Taşcı Bozbaş, Gülnur , Öztürk, Hakan . "Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs". The European Research Journal 5 / 1 (Ocak 2019): 104-108. http://dx.doi.org/10.18621/eurj.359504