Yıl 2019, Cilt 5, Sayı 1, Sayfalar 14 - 19 2019-01-04

The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Pınar Karakaya [1] , Bahar Özdemir [2] , Meral Mert [3] , Hakan Koçoğlu [4] , Abdulbaki Kumbasar [5]

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Objective: In this study, we aimed to determine the relationship between the atrial natriuretic peptide and microvascular complications of diabetes.

Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study. Patients with a chronic disease other than diabetes mellitus were excluded from the study. The body-mass index, waist circumference, and hip circumference were measured and blood samples for routine biochemical tests were taken after at least 12 hours fasting. The microvascular complications of the patients were evaluated.

Results: Thirty-two of the patients had microvascular complications whereas 28 of them did not. Age, body mass index, waist and hip circumference, and atrial natriuretic peptide levels were significantly higher in the group with microvascular complications than those without complications. There was no significant difference in parameters like; waist-hip ratio, blood glucose, HbA1c, fasting insulin, fasting HOMA, sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between atrial natriuretic peptide and obesity, retinopathy, neuropathy, nephropathy, duration of diabetes, HbA1c, and sex are evaluated separately, the only significant parameters related to atrial natriuretic peptide were the body-mass index, waist circumference, hip circumference measurements, and neuropathy.

Conclusions: Positive correlations between serum atrial natriuretic peptide levels and body-mass index, waist circumference, and hip circumference measurements were determined. Also, serum atrial natriuretic peptide levels were significantly higher in patients with obesity or neuropathy than those without obesity or neuropathy. 

Atrial natriuretic peptide, diabetes mellitus, microvascular complications
  • [1] de Bold AJ. Atrial natriuretic factor: a hormone produced by the heart. Science. 1985;230:767-70.
  • [2] Nosadini R, Semplicini A, Fioretto P, Lusiani L, Trevisan R, Donadon V, et al. Sodium-lithium countertransport and cardiorenal abnormalities in essential hypertension. Hypertension 1991;18:191-8.
  • [3] Fine LG, Badie-Dezfooly B, Lowe AG, Hamzeh A, Wells J, Salehmoghaddam S. Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells. Proc Natl Acad Sci U S A 1985;82:1736-40.
  • [4] Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, et al. Impact of obesity on plasma natriuretic peptide levels. Circulation 2004;109:594-600.
  • [5] Nannipieri M, Seghieri G, Catalano C, Prontera T, Baldi S, Ferrannini E. Defective regulation and action of atrial natriuretic peptide in type 2 diabetes. Horm Metab Res 2002;34:265-70.
  • [6] Moro C, Berlan M. Cardiovascular and metabolic effects of natriuretic peptides. Fundam Clin Pharmacol 2006;20:41-9.
  • [7] Boyuk B, Atalay H, Degirmencioglu S, Altay M, Guzel S, Celebi A, et al. Is there a relation between serum vitamin D level and microvascular comlications in type 2 diabetes? Eurasian J Med Oncol 2017;1:190-6.
  • [8] Jacobs EM, Vervoort G, Branten AJ, Klasen I, Smits P, Wetzels JF. Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption. Eur J Clin Invest 1999;29:109-15.
  • [9] McKenna K, Smith D, Sherlock M, Moore K, O'Brien E, Tormey W, et al. Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects. Ir J Med Sci 2005;174:53-7.
  • [10] Vesely DL, Gower WR, Jr., Dietz JR, Overton RM, Clark LC, Antwi EK, et al. Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. Metabolism 1999;48:771-8.
  • [11] Rollin R, Mediero A, Martinez-Montero JC, Roldan-Pallares M, Suarez-Leoz M, Vidal-Fernandez P, et al. Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. Mol Vis 2004;10:450-7.
  • [12] Salas-Ramirez M, Ariza Andraca R, Frati Munari A, Munoz H, Altamirano P. Effect of plasma volume expansion on auricular natriuretic peptide in non-dependent insulin diabetic patients with autonomic neuropathy. Arch Med Res 1995;26:35-40.
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Yazarlar

Orcid: 0000-0003-3337-4423
Yazar: Pınar Karakaya
Kurum: Department of Endocrinology and Metabolic Diseases, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Ülke: Turkey


Orcid: 0000-0003-4111-2941
Yazar: Bahar Özdemir
Kurum: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Ülke: Turkey


Orcid: 0000-0003-3431-0915
Yazar: Meral Mert
Kurum: Department of Endocrinology and Metabolic Diseases, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Ülke: Turkey


Orcid: 0000-0002-9208-2693
Yazar: Hakan Koçoğlu (Sorumlu Yazar)
Kurum: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Ülke: Turkey


Orcid: 0000-0001-7466-9434
Yazar: Abdulbaki Kumbasar
Kurum: Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj410990, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {14 - 19}, doi = {10.18621/eurj.410990}, title = {The relationship between atrial natriuretic peptide and microvascular complications of diabetes}, key = {cite}, author = {Karakaya, Pınar and Özdemir, Bahar and Mert, Meral and Koçoğlu, Hakan and Kumbasar, Abdulbaki} }
APA Karakaya, P , Özdemir, B , Mert, M , Koçoğlu, H , Kumbasar, A . (2019). The relationship between atrial natriuretic peptide and microvascular complications of diabetes. The European Research Journal, 5 (1), 14-19. DOI: 10.18621/eurj.410990
MLA Karakaya, P , Özdemir, B , Mert, M , Koçoğlu, H , Kumbasar, A . "The relationship between atrial natriuretic peptide and microvascular complications of diabetes". The European Research Journal 5 (2019): 14-19 <http://dergipark.gov.tr/eurj/issue/40357/410990>
Chicago Karakaya, P , Özdemir, B , Mert, M , Koçoğlu, H , Kumbasar, A . "The relationship between atrial natriuretic peptide and microvascular complications of diabetes". The European Research Journal 5 (2019): 14-19
RIS TY - JOUR T1 - The relationship between atrial natriuretic peptide and microvascular complications of diabetes AU - Pınar Karakaya , Bahar Özdemir , Meral Mert , Hakan Koçoğlu , Abdulbaki Kumbasar Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.410990 DO - 10.18621/eurj.410990 T2 - The European Research Journal JF - Journal JO - JOR SP - 14 EP - 19 VL - 5 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.410990 UR - http://dx.doi.org/10.18621/eurj.410990 Y2 - 2018 ER -
EndNote %0 The European Research Journal The relationship between atrial natriuretic peptide and microvascular complications of diabetes %A Pınar Karakaya , Bahar Özdemir , Meral Mert , Hakan Koçoğlu , Abdulbaki Kumbasar %T The relationship between atrial natriuretic peptide and microvascular complications of diabetes %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 1 %R doi: 10.18621/eurj.410990 %U 10.18621/eurj.410990
ISNAD Karakaya, Pınar , Özdemir, Bahar , Mert, Meral , Koçoğlu, Hakan , Kumbasar, Abdulbaki . "The relationship between atrial natriuretic peptide and microvascular complications of diabetes". The European Research Journal 5 / 1 (Ocak 2019): 14-19. http://dx.doi.org/10.18621/eurj.410990