Yıl 2019, Cilt 5, Sayı 1, Sayfalar 159 - 165 2019-01-04

Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis

Kadir Kaan Özsin [1] , Umut Serhat Sanrı [2] , Faruk Toktaş [3] , İbrahim Burak Şeker [4] , Şenol Yavuz [5]

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Objectives: We aim to evaluate the relationship between serum lipid indices and carotid artery stenosis (CAS).

Methods: This retrospective observational study included patients who underwent carotid endarterectomy (CEA) and unoperated patients who have CAS less than 50%. CAS was diagnosed with history and physical examination followed by doppler ultrasonography, coronary and carotid angiography. All data retrieved retrospectively from the hospital medical files. Non-high-density lipoprotein-cholesterol (non-HDL-C) level was calculated by removing HDL-C from total cholesterol. In addition, low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio, non-HDL-C/HDL-C ratio, and triglyceride (TG)/HDL-C ratio were assessed.

Results: CEA group (77.5% male, mean age: 71.35 ± 8.35 years) included 40 patients who underwent CEA, and there were 32 patients who have less than 50% CAS in unoperated group (68.8% male, mean age: 63.94 ± 9.92 years). The development of CAS was not significantly correlated with LDL-C/HDL-C ratio (p = 0.119), non-HDL-C/HDL-C ratio (p = 0.227) and TG/HDL-C ratio (p = 0.768). Advanced age and presence of coronary artery disease were identified as an independent predictor of the development of CAS. For predicting development of CAS, there were 50.0% sensitivity and 65.6% specificity for LDL-C/HDL-C ratio and non-HDL-C/ HDL-C ratio (area under the curve [AUC]: 0.592, log rank p = 0.183, AUC: 0.583, log rank p = 0.227, respectively).

Conclusions: We found that lipid ratios were not an independent predictors of the development of CAS. But, we think that AUC values which were above 0.5 for lipid ratios are may be important development of CAS. 

Carotid artery stenosis, lipid levels, disease progression
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Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0001-5933-9322
Yazar: Kadir Kaan Özsin (Sorumlu Yazar)
Kurum: Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0003-4008-4336
Yazar: Umut Serhat Sanrı
Kurum: Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-0820-3879
Yazar: Faruk Toktaş
Kurum: Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0002-5145-4921
Yazar: İbrahim Burak Şeker
Kurum: Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0001-5246-0808
Yazar: Şenol Yavuz
Kurum: Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj444384, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {159 - 165}, doi = {10.18621/eurj.444384}, title = {Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis}, key = {cite}, author = {Yavuz, Şenol and Şeker, İbrahim Burak and Sanrı, Umut Serhat and Özsin, Kadir Kaan and Toktaş, Faruk} }
APA Özsin, K , Sanrı, U , Toktaş, F , Şeker, İ , Yavuz, Ş . (2019). Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis. The European Research Journal, 5 (1), 159-165. DOI: 10.18621/eurj.444384
MLA Özsin, K , Sanrı, U , Toktaş, F , Şeker, İ , Yavuz, Ş . "Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis". The European Research Journal 5 (2019): 159-165 <http://dergipark.gov.tr/eurj/issue/40357/444384>
Chicago Özsin, K , Sanrı, U , Toktaş, F , Şeker, İ , Yavuz, Ş . "Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis". The European Research Journal 5 (2019): 159-165
RIS TY - JOUR T1 - Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis AU - Kadir Kaan Özsin , Umut Serhat Sanrı , Faruk Toktaş , İbrahim Burak Şeker , Şenol Yavuz Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.444384 DO - 10.18621/eurj.444384 T2 - The European Research Journal JF - Journal JO - JOR SP - 159 EP - 165 VL - 5 IS - 1 SN - -2149-3189 M3 - doi: 10.18621/eurj.444384 UR - http://dx.doi.org/10.18621/eurj.444384 Y2 - 2018 ER -
EndNote %0 The European Research Journal Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis %A Kadir Kaan Özsin , Umut Serhat Sanrı , Faruk Toktaş , İbrahim Burak Şeker , Şenol Yavuz %T Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 1 %R doi: 10.18621/eurj.444384 %U 10.18621/eurj.444384
ISNAD Özsin, Kadir Kaan , Sanrı, Umut Serhat , Toktaş, Faruk , Şeker, İbrahim Burak , Yavuz, Şenol . "Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis". The European Research Journal 5 / 1 (Ocak 2019): 159-165. http://dx.doi.org/10.18621/eurj.444384