Yıl 2019, Cilt 5, Sayı 2, Sayfalar 268 - 273 2019-03-04

Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival

Özlem Yersal [1] , Mehmet Yiğit [2] , Nezih Meydan [3] , Sabri Barutca [4]

74 214

Objectives: The aim of this study was to analyze high risk breast cancer patients with involvement of five or more axillary lymph nodes with an overall survival of at least five years, and to determine the predictive and prognostic factors by comparing patients by recurrence/metastases status retrospectively.

Methods: From a total of 500 patients those were followed up in Adnan Menderes University, Medical Oncology department, 37 were eligible for the study; 23 were disease free and 14 had recurrence/metastases in the follow up period. The patients were analyzed, for demographical (such as age, menopausal status, obesity), anatomical and histological characteristics of tumor (primary tumor’s diameter, stage, grade, Ki-67, hormon receptors and Her-2 status), treatment modalities and prognosis.

Results: Both number of metastatic lymph nodes and (metastatic/sampled) lymph node ratio were not significantly different between the recurrence-free and metastatic patients. In the recurrence-free patients both grade 3 (48% vs none, p = 0.03) and p53 negative tumors (64% vs 36%, p = 0.036) were significantly more than metastatic patients. Also in the recurrence free patients as compared to metastatic patients, adjuvant chemotherapy was applied more than 6 cycles (87% vs 43%, p = 0.004), the regimens included more taxane based regimens (91% vs 64%, p = 0.042), aromatase inhibitors were used higher (100% vs 75%, p = 0.019) and the period of tamoxifen treatment in switch regimens were shorter.

Conclusion: The results of this study suggested that, high risk breast cancer patients with involvement of five and more nodes that have the predictive factors as grade 3 and/or p53 negative tumors are propably more responsive to adjuvant treatments. Chemotherapy of more than 6 cycles, administering taxane based regimens and aromatase inhibitors in the adjuvant regimens may favourably effect the prognosis.

breast cancer, lymph node metastases, predictive and prognostic factors
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Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0001-8220-4223
Yazar: Özlem Yersal
Kurum: Department of Medical Oncology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0002-7359-2137
Yazar: Mehmet Yiğit
Kurum: Department of Medical Oncology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0003-4100-5804
Yazar: Nezih Meydan
Kurum: Department of Medical Oncology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Orcid: 0000-0002-1941-0531
Yazar: Sabri Barutca
Kurum: Department of Medical Oncology, Adnan Menderes University School of Medicine, Aydın, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj368447, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {268 - 273}, doi = {10.18621/eurj.368447}, title = {Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival}, key = {cite}, author = {Yersal, Özlem and Yiğit, Mehmet and Meydan, Nezih and Barutca, Sabri} }
APA Yersal, Ö , Yiğit, M , Meydan, N , Barutca, S . (2019). Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival. The European Research Journal, 5 (2), 268-273. DOI: 10.18621/eurj.368447
MLA Yersal, Ö , Yiğit, M , Meydan, N , Barutca, S . "Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival". The European Research Journal 5 (2019): 268-273 <http://dergipark.gov.tr/eurj/issue/41339/368447>
Chicago Yersal, Ö , Yiğit, M , Meydan, N , Barutca, S . "Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival". The European Research Journal 5 (2019): 268-273
RIS TY - JOUR T1 - Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival AU - Özlem Yersal , Mehmet Yiğit , Nezih Meydan , Sabri Barutca Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.368447 DO - 10.18621/eurj.368447 T2 - The European Research Journal JF - Journal JO - JOR SP - 268 EP - 273 VL - 5 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.368447 UR - http://dx.doi.org/10.18621/eurj.368447 Y2 - 2018 ER -
EndNote %0 The European Research Journal Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival %A Özlem Yersal , Mehmet Yiğit , Nezih Meydan , Sabri Barutca %T Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 2 %R doi: 10.18621/eurj.368447 %U 10.18621/eurj.368447
ISNAD Yersal, Özlem , Yiğit, Mehmet , Meydan, Nezih , Barutca, Sabri . "Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival". The European Research Journal 5 / 2 (Mart 2019): 268-273. http://dx.doi.org/10.18621/eurj.368447