Yıl 2019, Cilt 5, Sayı 2, Sayfalar 299 - 305 2019-03-04

Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Hasan Metineren [1] , Turan Cihan Dülgeroğlu [2]

54 296

Objectives: Different materials are currently being used experimentally to accelerate cartilage healing and to obtain hyaline cartilage. We aimed to investigate the effect of platelet-rich fibrin on joint cartilage healing.

Methods: Twenty rats were used in this study. platelet-rich fibrin was obtained from 4 rats, and the remaining 16 rats were randomly divided into two groups (4 and 8 weeks). Both knee joints were prepared, and an osteochondral defect was created at the femoral condyle in all rats. platelet-rich fibrin was placed into the osteochondral defect of the right knee, while the left knee joint was used as a control. Groups were sacrificed after 4 and 8 weeks, respectively.

Results: According to the O'Driscoll score, there were no significant differences between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue after 8 weeks in the platelet-rich fibrin group.

Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects. 

Articular cartilage, chondral healing, experimental rat model, hyaline cartilage, platelet-rich fibrin
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Konular Sağlık Bilimleri ve Hizmetleri
Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0002-5671-6273
Yazar: Hasan Metineren (Sorumlu Yazar)
Kurum: Department of Orthopaedics and Traumatology, Dumlupınar University School of Medicine, Kütahya, Turkey
Ülke: Turkey


Orcid: 0000-0002-9661-5418
Yazar: Turan Cihan Dülgeroğlu
Kurum: Department of Orthopaedics and Traumatology, Dumlupınar University School of Medicine, Kütahya, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj373385, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {299 - 305}, doi = {10.18621/eurj.373385}, title = {Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model}, key = {cite}, author = {Metineren, Hasan and Dülgeroğlu, Turan Cihan} }
APA Metineren, H , Dülgeroğlu, T . (2019). Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model. The European Research Journal, 5 (2), 299-305. DOI: 10.18621/eurj.373385
MLA Metineren, H , Dülgeroğlu, T . "Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model". The European Research Journal 5 (2019): 299-305 <http://dergipark.gov.tr/eurj/issue/41339/373385>
Chicago Metineren, H , Dülgeroğlu, T . "Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model". The European Research Journal 5 (2019): 299-305
RIS TY - JOUR T1 - Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model AU - Hasan Metineren , Turan Cihan Dülgeroğlu Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.373385 DO - 10.18621/eurj.373385 T2 - The European Research Journal JF - Journal JO - JOR SP - 299 EP - 305 VL - 5 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.373385 UR - http://dx.doi.org/10.18621/eurj.373385 Y2 - 2018 ER -
EndNote %0 The European Research Journal Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model %A Hasan Metineren , Turan Cihan Dülgeroğlu %T Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 2 %R doi: 10.18621/eurj.373385 %U 10.18621/eurj.373385
ISNAD Metineren, Hasan , Dülgeroğlu, Turan Cihan . "Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model". The European Research Journal 5 / 2 (Mart 2019): 299-305. http://dx.doi.org/10.18621/eurj.373385