Yıl 2019, Cilt 5, Sayı 2, Sayfalar 250 - 257 2019-03-04

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Oğuz Eroğlu [1] , Nermin Dindar Badem [2] , Ayşe Baccıoğlu [3] , Ertan Cömertpay [4] , Salim Neşelioğlu [5] , Özcan Erel [6]

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Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients.

Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects’ demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software.

Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD. 

Chronic obstructive pulmonary disease, oxidative stress, thiol/disulphide homeostasis, ischemia modified albumin
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Dergi Bölümü Original Article
Yazarlar

Orcid: 0000-0001-7033-8566
Yazar: Oğuz Eroğlu (Sorumlu Yazar)
Kurum: Department of Emergency Medicine, Kırıkkale University School of Medicine, Kırıkkale, Turkey
Ülke: Turkey


Orcid: 0000-0002-5095-7818
Yazar: Nermin Dindar Badem
Kurum: Department of Medical Biochemistry, Kırıkkale University School of Medicine, Kırıkkale, Turkey
Ülke: Turkey


Orcid: 0000-0002-9853-9201
Yazar: Ayşe Baccıoğlu
Kurum: Department of Pulmonary Diseases, Division of Immunology and Allergy Diseases, Kırıkkale University School of Medicine, Kırıkkale, Turkey
Ülke: Turkey


Orcid: 0000-0002-8648-5963
Yazar: Ertan Cömertpay
Kurum: Department of Emergency Medicine, Kırıkkale University School of Medicine, Kırıkkale, Turkey
Ülke: Turkey


Orcid: 0000-0002-0974-5717
Yazar: Salim Neşelioğlu
Kurum: Department of Clinical Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Ülke: Turkey


Orcid: 0000-0002-2996-3236
Yazar: Özcan Erel
Kurum: Department of Clinical Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { eurj425178, journal = {The European Research Journal}, issn = {}, eissn = {2149-3189}, address = {Sağlık Araştırmaları ve Stratejileri Derneği}, year = {2019}, volume = {5}, pages = {250 - 257}, doi = {10.18621/eurj.425178}, title = {Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease}, key = {cite}, author = {Eroğlu, Oğuz and Dindar Badem, Nermin and Baccıoğlu, Ayşe and Cömertpay, Ertan and Neşelioğlu, Salim and Erel, Özcan} }
APA Eroğlu, O , Dindar Badem, N , Baccıoğlu, A , Cömertpay, E , Neşelioğlu, S , Erel, Ö . (2019). Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease. The European Research Journal, 5 (2), 250-257. DOI: 10.18621/eurj.425178
MLA Eroğlu, O , Dindar Badem, N , Baccıoğlu, A , Cömertpay, E , Neşelioğlu, S , Erel, Ö . "Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease". The European Research Journal 5 (2019): 250-257 <http://dergipark.gov.tr/eurj/issue/41339/425178>
Chicago Eroğlu, O , Dindar Badem, N , Baccıoğlu, A , Cömertpay, E , Neşelioğlu, S , Erel, Ö . "Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease". The European Research Journal 5 (2019): 250-257
RIS TY - JOUR T1 - Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease AU - Oğuz Eroğlu , Nermin Dindar Badem , Ayşe Baccıoğlu , Ertan Cömertpay , Salim Neşelioğlu , Özcan Erel Y1 - 2019 PY - 2019 N1 - doi: 10.18621/eurj.425178 DO - 10.18621/eurj.425178 T2 - The European Research Journal JF - Journal JO - JOR SP - 250 EP - 257 VL - 5 IS - 2 SN - -2149-3189 M3 - doi: 10.18621/eurj.425178 UR - http://dx.doi.org/10.18621/eurj.425178 Y2 - 2018 ER -
EndNote %0 The European Research Journal Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease %A Oğuz Eroğlu , Nermin Dindar Badem , Ayşe Baccıoğlu , Ertan Cömertpay , Salim Neşelioğlu , Özcan Erel %T Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 2 %R doi: 10.18621/eurj.425178 %U 10.18621/eurj.425178
ISNAD Eroğlu, Oğuz , Dindar Badem, Nermin , Baccıoğlu, Ayşe , Cömertpay, Ertan , Neşelioğlu, Salim , Erel, Özcan . "Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease". The European Research Journal 5 / 2 (Mart 2019): 250-257. http://dx.doi.org/10.18621/eurj.425178