Yıl 2018, Cilt 1, Sayı 2, Sayfalar 51 - 54 2018-09-01

Ischemia-Reperfusion Damage
İskemi-Reperfüzyon Hasarı

Halis Süleyman [1] , Vahdet Gül [2] , Erkan Hirik [3]

25 117

The ischemia is the lack of oxygen due to the reduction or complete interruption in blood supply to the tissue. On the contrary, reperfusion is the process of restoring the blood flow to the ischemic tissue. However, sudden reperfusion of ischemic tissue paradoxically may result in much more severe damage to the tissue than ischemia-induced damage alone.

Increased free oxygen radicals (SOR) are implicated in reperfusion injury. High amounts of molecular oxygen supplied to the ischemic tissue by fresh arterial blood are thought to have the potential to generate more SOR, eventually more tissue damage. Another source of SOR in the reperfusion is activated polymorph- nuclear leukocytes.

The cyclooxygenase-2 (COX-2) enzyme becomes active in the reperfusion of ischemic tissue.  This enzyme allows the pro-inflammatory prostaglandins and SORs to be released from arachidonic acid. Ischemic reperfusion is a complex pathological process that begins with oxygen-free ambient in tissue, continues with SOR production, and followed by an inflammation in tissue effected.


İskemi, dokuya gelen kan akımının azalması veya tamamen kesilmesine bağlı dokunun oksijenden yoksun kalmasıdır. Reperfüzyon ise, iskemik dokunun yeniden kanlanmasını sağlamaktır.

Ancak, iskemik dokunun hızlı reperfüzyonu dokuda paradoksal olarak sadece iskemi ile oluşan hasara karşın, çok daha şiddetli hasarlara yol açabildiği rapor edilmiştir.

Reperfüzyon hasarında, iskemik dokuya arteryel kanla sunulan bol miktarlardaki moleküler oksijenin, yoğun serbest oksijen radikalleri (SOR) oluşturması sorumlu tutulmaktadır. Reperfüzyon da SOR üreten diğer bir kaynak da, aktive olmuş polimorf - nükleer lökositlerdir. İskemik doku reperfüzyonunda siklo-oksijenaz-2 (COX-2) enzimi aktif hale gelir. Bu enzim, araşidonik asitten proinflamatuar prostoglandinler ve  SOR’ ların açığa çıkmasına yol açabilmektedir.

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Birincil Dil tr
Konular Mühendislik, Ortak Disiplinler
Dergi Bölümü Makaleler
Yazarlar

Yazar: Halis Süleyman (Sorumlu Yazar)
Kurum: ERZİNCAN ÜNİVERSİTESİ
Ülke: Turkey


Yazar: Vahdet Gül
Kurum: ERZİNCAN ÜNİVERSİTESİ
Ülke: Turkey


Yazar: Erkan Hirik
Kurum: ERZİNCAN ÜNİVERSİTESİ
Ülke: Turkey


Bibtex @derleme { eutd454922, journal = {Erzincan Tıp Dergisi}, issn = {}, eissn = {2630-628X}, address = {Erzincan Üniversitesi}, year = {2018}, volume = {1}, pages = {51 - 54}, doi = {}, title = {İskemi-Reperfüzyon Hasarı}, key = {cite}, author = {Süleyman, Halis and Gül, Vahdet and Hirik, Erkan} }
APA Süleyman, H , Gül, V , Hirik, E . (2018). İskemi-Reperfüzyon Hasarı. Erzincan Tıp Dergisi, 1 (2), 51-54. Retrieved from http://dergipark.gov.tr/eutd/issue/39026/454922
MLA Süleyman, H , Gül, V , Hirik, E . "İskemi-Reperfüzyon Hasarı". Erzincan Tıp Dergisi 1 (2018): 51-54 <http://dergipark.gov.tr/eutd/issue/39026/454922>
Chicago Süleyman, H , Gül, V , Hirik, E . "İskemi-Reperfüzyon Hasarı". Erzincan Tıp Dergisi 1 (2018): 51-54
RIS TY - JOUR T1 - İskemi-Reperfüzyon Hasarı AU - Halis Süleyman , Vahdet Gül , Erkan Hirik Y1 - 2018 PY - 2018 N1 - DO - T2 - Erzincan Tıp Dergisi JF - Journal JO - JOR SP - 51 EP - 54 VL - 1 IS - 2 SN - -2630-628X M3 - UR - Y2 - 2018 ER -
EndNote %0 Erzincan Tıp Dergisi İskemi-Reperfüzyon Hasarı %A Halis Süleyman , Vahdet Gül , Erkan Hirik %T İskemi-Reperfüzyon Hasarı %D 2018 %J Erzincan Tıp Dergisi %P -2630-628X %V 1 %N 2 %R %U
ISNAD Süleyman, Halis , Gül, Vahdet , Hirik, Erkan . "İskemi-Reperfüzyon Hasarı". Erzincan Tıp Dergisi 1 / 2 (Eylül 2018): 51-54.