Cilt 7, Sayı 2, Sayfalar 120 - 125 2017-05-26

Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu
Low plasminogen activator inhibitor-1 levels in thyroid carcinoma: uPA/PAI-1 paradox in cancer proggression

Bekir Ucan [1] , Muhammed Kizilgul [2] , Mustafa Sahin [3] , Mustafa Ozbek [4] , Seyda Ozdemir [5] , Erman Cakal [6]

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Amaç: Plazminojen aktivatör inhibitor-1 (PAI-1) hücre migrasyon ve apoptozisinin güçlü inhibitörüdür. Çoğu kanser türünde yüksek PAI-1 düzeyleri tespit edilmiştir. Bir çok çalışmada tiroid kanserlerinde artmış PAI-1 ekspresyonu ve bunun kötü klinik sonuçlarla ilişkili olduğu gösterilmiştir. Bu çalışmada papiller tiroid kanserlerinde(PTK) serum PAI-1 düzeylerini ve bunun PTK gelişimi ve boyutu üzerine etkisini araştırmak amaçlanmıştır.
Materyal ve Metod: Elli dört papiller tiroid kanser hastası (7 erkek, 47 kadın) ve 24 sağlıklı kontrol (6 erkek, 18 kadın) çalışmaya dahil edilmiştir.  Gruplar dermografik, antropometrik ve biyokimyasal veriler ile serum PAI-1 düzeyleri açısından  karşılaştırılmıştır. Serum PAI-1 düzeyleri enzim-bağlı immünabsorban kit (ELİZA) ile çalışılmıştır.
Results: Ortalama yaş PTK ve kontrol grubunda benzerdi (42.4 ± 10.1 ile 42.5 ± 8.9, p:0.794). Serum PAI-1 düzeyleri sağlıklı kontrollerle karşılaştırıldığında PTK hastalarında düşük olarak saptandı (241.34 ± 107.82 ile 327.24 ± 138.51, p:0.011). Vücut kitle indeksi (VKİ), Homa-IR, TSH, sT4, anti-TPO, anti-Tg, total kolesterol, trigliserid, HDL-kolesterol, LDL-kolesterol, kalsiyum, fosfor, 25-OH-VitD, parathormon, glukoz, insülin düzeyleri gruplar arasında benzer olarak bulundu (p>0.05). PTK hastalarında PAI-1 düzeyleri ile parathormon(PTH) dışında klinik, biyokimyasal ve hormonal parametreler arasında korelasyon bulunamadı (r:-0.446, p:0.0027).
Conclusions: Papiller tiroid kanserli hastalarda serum PAI-1 düzeyleri düşük olarak bulunmuştur. Bizim sonuçlarımız ürokinaz plazminojen aktivatör aktivitesini inhibisyon kapasitesinden dolayı kanser ilerlemesini baskılaması beklentisi tezini destekleyebilir.


Aim: Plasminogen activator inhibitor-1 (PAI-1) potently inhibits cell migration and apoptosis. Increased levels of PAI-1 were demonstrated in a great variety of cancers. Many studies demonstrated increased expression of PAI-1 in thyroid cancer and its relation to unfavorable clinical outcome. In this study, we aimed to investigate serum PAI-1 levels in patients with papillary thyroid carcinoma (PTC) as well as its effect in development and size of PTC.

Material and methods: Fifty-four papillary thyroid cancer patients (7 male, 47 female) and 24 healthy controls (6 male, 18 female) were enrolled in the study. Groups were compared by demographic, anthropometric, biochemical data, and by serum ghrelin levels. Serum PAI-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results: Mean age were similar between PTC and control group (42.4 ± 10.1 to 42.5 ± 8.9, p:0.794). Serum PAI-1 levels were lower in patients with PTC when compared to healthy controls (241.34 ± 107.82 to 327.24 ± 138.51, p:0.011). BMI, Homa-IR and TSH, FT4, anti-TPO, anti-Tg, total cholesterol, triglyceride, HDL-Cholesterol, LDL-Cholesterol, calcium, phosphorus, 25-OH-VitD, parathormone, glucose, insülin concentrations were similar between groups (p>0.05). PAI-1 concentrations were not correlated with clinical, biochemical and hormonal parameters except parathormone (PTH) concentrations in PTC group (r:-0.446, p:0.0027).

Conclusions: Serum PAI-1 levels were lower in patients with papillary thyroid carcinoma. Our results might support the thesis of PAI-1 is expected to suppress cancer progression due to its ability to inhibit urokinase plasminogen activator activity.


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Konular Sağlık Bilimleri
Dergi Bölümü Orjinal Çalışma
Yazarlar

Yazar: Bekir Ucan
E-posta: uzm.dr.bekir@hotmail.com
Kurum: Diskapi Yildirim Beyazit Teaching and Research Hospital, Department of Endocrinology and Metabolism, Ankara
Ülke: Turkey


Yazar: Muhammed Kizilgul
E-posta: muhammedkzgl@gmail.com
Kurum: Beyazit Teaching and Research Hospital, Department of Endocrinology and Metabolism, Ankara,
Ülke: Turkey


Yazar: Mustafa Sahin
E-posta: drsahinmustafa@yahoo.com
Kurum: Ankara University, School of Medicine, Department of Endocrinology and Metabolism, Ankara
Ülke: Turkey


Yazar: Mustafa Ozbek
E-posta: mustafaozbek10@hotmail.com
Kurum: Diskapi Yildirim Beyazit Teaching and Research Hospital, Department of Endocrinology and Metabolism, Ankara
Ülke: Turkey


Yazar: Seyda Ozdemir
E-posta: seydaozdemir@hotmail.com
Kurum: Diskapi Yildirim Beyazit Teaching and Research Hospital, Department of Biochemistry, Ankara
Ülke: Turkey


Yazar: Erman Cakal
E-posta: ermancakal@hotmail.com
Kurum: Diskapi Yildirim Beyazit Teaching and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { gopctd316172, journal = {Journal of Contemporary Medicine}, issn = {}, address = {Gaziosmanpaşa Üniversitesi}, year = {2017}, volume = {7}, pages = {120 - 125}, doi = {10.16899/gopctd.316172}, title = {Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu}, language = {tr}, key = {cite}, author = {Ozdemir, Seyda and Sahin, Mustafa and Ozbek, Mustafa and Kizilgul, Muhammed and Cakal, Erman and Ucan, Bekir} } @araştırma makalesi { gopctd316172, journal = {Journal of Contemporary Medicine}, issn = {}, address = {Gaziosmanpaşa Üniversitesi}, year = {2017}, volume = {7}, pages = {120 - 125}, doi = {10.16899/gopctd.316172}, title = {Low plasminogen activator inhibitor-1 levels in thyroid carcinoma: uPA/PAI-1 paradox in cancer proggression}, language = {en}, key = {cite}, author = {Ozdemir, Seyda and Sahin, Mustafa and Ozbek, Mustafa and Kizilgul, Muhammed and Cakal, Erman and Ucan, Bekir} }
APA Ucan, B , Kizilgul, M , Sahin, M , Ozbek, M , Ozdemir, S , Cakal, E . (2017). Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu. Journal of Contemporary Medicine, 7 (2), 120-125. DOI: 10.16899/gopctd.316172
MLA Ucan, B , Kizilgul, M , Sahin, M , Ozbek, M , Ozdemir, S , Cakal, E . "Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu". Journal of Contemporary Medicine 7 (2017): 120-125 <http://dergipark.gov.tr/gopctd/issue/27034/316172>
Chicago Ucan, B , Kizilgul, M , Sahin, M , Ozbek, M , Ozdemir, S , Cakal, E . "Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu". Journal of Contemporary Medicine 7 (2017): 120-125
RIS TY - JOUR T1 - Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu AU - Bekir Ucan , Muhammed Kizilgul , Mustafa Sahin , Mustafa Ozbek , Seyda Ozdemir , Erman Cakal Y1 - 2017 PY - 2017 N1 - doi: 10.16899/gopctd.316172 DO - 10.16899/gopctd.316172 T2 - Journal of Contemporary Medicine JF - Journal JO - JOR SP - 120 EP - 125 VL - 7 IS - 2 SN - -2146-6009 M3 - doi: 10.16899/gopctd.316172 UR - http://dx.doi.org/10.16899/gopctd.316172 Y2 - 2017 ER -
EndNote %0 Journal of Contemporary Medicine Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu %A Bekir Ucan , Muhammed Kizilgul , Mustafa Sahin , Mustafa Ozbek , Seyda Ozdemir , Erman Cakal %T Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu %D 2017 %J Journal of Contemporary Medicine %P -2146-6009 %V 7 %N 2 %R doi: 10.16899/gopctd.316172 %U 10.16899/gopctd.316172