Year 2019, Volume 9, Issue 1, Pages 55 - 58 2019-03-27

Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections
Üriner Sistem İnfeksiyonlarına neden Olan Genişlemiş Spektrumlu Beta-laktamaz Üreten Escherichia coli ve Klebsiella pneumoniae İzolatlarının Fosfomisin ve Nitrofurantoine Duyarlılıkları

UMUT SAFİYE ŞAY COŞKUN [1]

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Aim: The most common causative agents of urinary tract infections are Esherichia coli and Klebsiella pneumoniae. Increasing numbers of extanded spectrum beta-lactamase producing  isolates led to the search for alternative antibiotics in the treatment of urinary tract infections caused by Esherichia coli and Klebsiella pneumoniae isolates producing extanded spectrum beta-lactamase. This studies aim is to determine the sensitivity of fosfomycin and nitrofurantoin to extanded spectrum beta-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates, which are defined by patients in our hospital, to contribute to the planning of empirical treatment of these patients.

Matheryals and Methods: Patients urinary specimens from various services and intensive care unit were evaluated retrospectively. Identification of isolates and antibiotic susceptibility were evaluated with the VITEK 2 ID (bioMérieux, France) automatization system.

Results: Extended spectrum β-lactamase producing 85 Esherichia coli and 23 Klebsiella pneumoniae were included in the study. The isolates were identified from the most frequent cases from the intensive care unit (43.5 %). The most sensitive antibiotics are carbapenems. Susceptibility rates to Esherichia coli and Klebsiella pneumoniae isolates were respectively 100% and 87% to carbapenems followed by 98% and 83% to fosfomycin 94% and 30.4% to nitrofurantoin.

Conclusions: Fosfomycin is seen as a good alternative agent in urinary tract infections caused by extanded spectrum beta-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates in our hospital for emprical treatment. 

Amaç: Üriner sistem enfeksiyonlarına en sık neden olan etkenler Esherichia coli ve Klebsiella pneumoniae’dır. Genişlemiş spektrumlu beta laktamaz üreten izolatlarının giderek artıyor olması genişlemiş spektrumlu beta laktamaz üreten E. coli ve Klebsiella pneumoniae  izolatlarının neden olduğu üriner sistem enfeksiyonlarının tedavisinde alternatif antibiyotik arayışını doğurmuştur. Bu çalışmanın amacı hastanemizde yatan hastalardan tanımlanan üriner sitem enfeksiyonuna neden olan genişlemiş spektrumlu beta laktamaz üreten Esherichia coli ve Klebsiella pneumoniae izolatlarında fosfomisin ve nitrofurantoine duyarlılığı tespit ederek, bu hastalarda ampirik tedavinin planlanmasına katkıda bulunmaktır.

Gereç ve Yöntem: Çeşitli servislerden ve yoğun bakım ünitesinden gönderilen hastalara ait idrar kültürü örnekleri retrospektif olarak değerlendirilmiştir. İzolatların tanımlanması ve antibiyotik duyarlılığının belirlenmesinde VITEK 2 ID (bioMérieux, Fransa) otomatize sistemi kullanılmıştır.

Bulgular: İzolatların en sık yoğun bakım ünitesinden (% 43.5) gelen örneklerden tanımlandığı saptanmıştır. İzolatlara karşı en duyarlı antbiyotikler ve duyarlılık oranları Esherichia coli ve Klebsiella pneumoniae için sırasıyla karbapenemlere  % 100 ve % 87 ardından fosfomisine % 98 ve % 83, nitrofurantoine % 94 ve % 30.4 tespit edilmiştir.

Sonuç: Hastanemizde yatan hastalarda genişlemiş spektrumlu beta laktamaz üreten Esherichia coli ve Klebsiella pneumoniae izolatlarının neden olduğu üriner sistem enfeksiyonlarında fosfomisinin ampirik tedavide iyi bir alternatif bir ajan olarak kullanılabileceği düşünülmüştür. 

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Research
Authors

Author: UMUT SAFİYE ŞAY COŞKUN (Primary Author)
Institution: TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ
Country: Turkey


Bibtex @research article { gopctd450476, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Selcuk University}, year = {2019}, volume = {9}, pages = {55 - 58}, doi = {10.16899/gopctd.450476}, title = {Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections}, key = {cite}, author = {ŞAY COŞKUN, UMUT SAFİYE} }
APA ŞAY COŞKUN, U . (2019). Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections. Çağdaş Tıp Dergisi, 9 (1), 55-58. DOI: 10.16899/gopctd.450476
MLA ŞAY COŞKUN, U . "Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections". Çağdaş Tıp Dergisi 9 (2019): 55-58 <http://dergipark.gov.tr/gopctd/issue/44052/450476>
Chicago ŞAY COŞKUN, U . "Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections". Çağdaş Tıp Dergisi 9 (2019): 55-58
RIS TY - JOUR T1 - Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections AU - UMUT SAFİYE ŞAY COŞKUN Y1 - 2019 PY - 2019 N1 - doi: 10.16899/gopctd.450476 DO - 10.16899/gopctd.450476 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 55 EP - 58 VL - 9 IS - 1 SN - -2146-6009 M3 - doi: 10.16899/gopctd.450476 UR - https://doi.org/10.16899/gopctd.450476 Y2 - 2019 ER -
EndNote %0 Çağdaş Tıp Dergisi Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections %A UMUT SAFİYE ŞAY COŞKUN %T Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections %D 2019 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 9 %N 1 %R doi: 10.16899/gopctd.450476 %U 10.16899/gopctd.450476
ISNAD ŞAY COŞKUN, UMUT SAFİYE . "Fosfomycin and Nitrofurantoin Susceptibilities of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extanded Spectrum Beta-lactamase Causing Urinary Tract Infections". Çağdaş Tıp Dergisi 9 / 1 (March 2019): 55-58. https://doi.org/10.16899/gopctd.450476