Yıl 2014, Cilt 4, Sayı 1, Sayfalar 1 - 5 2014-07-16

Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis
Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis

Yeliz Bilir [1] , Türker Taşlıyurt [2] , Faruk Kutlutürk [3] , Şafak Şahin [4] , Banu Öztürk [5] , Göknur Kalkan [6] , Süheyla Uzun Kaya [7] , Abdulkerim Yılmaz [8]

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Aim: Recently, it has been proposed that chronic inflammation in psoriasis lead to metabolic syndrome (MetS) development. There is limited data about the relationship between psoriasis and IR. Aim of the present study was to investigate the prevalence of IR and MetS in psoriasis patients and the association between the severities of illnesses.

Material and Method: The study consisted of 48 psoriasis patients and 45 healthy individuals. IR was estimated using homeostasis model assessment (HOMA) of IR formula. The psoriasis activity was evaluated by the psoriasis area and severity index (PASI). Patients were divided into 3 groups according to PASI scores.

Results: MetS was observed in 21 patients (43.75%) and 8 controls (17.77%) (p=0.007). IR was observed in 16 patients (33.33%) and 5 controls (11.11%) (p=0.01). The frequencies of MetS and IR increased in psoriasis patients compared to healthy controls. According to linear regression analysis, PASI was independent risk factor for IR development (p=0.003).

Conclusion: The incidences of MetS and IR were found to be higher in patients with psoriasis compared to control group. Especially there was a strong association between severe psoriasis and IR risk. Therefore, psoriasis needs to be considered as not only a skin disorder, but also a metabolic and cardiovascular disease

Aim: Recently, it has been proposed that chronic inflammation in psoriasis lead to metabolic syndrome (MetS) development. There is limited data about the relationship between psoriasis and IR. Aim of the present study was to investigate the prevalence of IR and MetS in psoriasis patients and the association between the severities of illnesses.

Material and Method: The study consisted of 48 psoriasis patients and 45 healthy individuals. IR was estimated using homeostasis model assessment (HOMA) of IR formula. The psoriasis activity was evaluated by the psoriasis area and severity index (PASI). Patients were divided into 3 groups according to PASI scores.

Results: MetS was observed in 21 patients (43.75%) and 8 controls (17.77%) (p=0.007). IR was observed in 16 patients (33.33%) and 5 controls (11.11%) (p=0.01). The frequencies of MetS and IR increased in psoriasis patients compared to healthy controls. According to linear regression analysis, PASI was independent risk factor for IR development (p=0.003).

Conclusion: The incidences of MetS and IR were found to be higher in patients with psoriasis compared to control group. Especially there was a strong association between severe psoriasis and IR risk. Therefore, psoriasis needs to be considered as not only a skin disorder, but also a metabolic and cardiovascular disease.

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Birincil Dil en
Konular
Dergi Bölümü Orjinal Çalışma
Yazarlar

Yazar: Yeliz Bilir

Yazar: Türker Taşlıyurt

Yazar: Faruk Kutlutürk

Yazar: Şafak Şahin

Yazar: Banu Öztürk

Yazar: Göknur Kalkan

Yazar: Süheyla Uzun Kaya

Yazar: Abdulkerim Yılmaz

Bibtex @ { gopctd95643, journal = {Journal of Contemporary Medicine}, issn = {}, eissn = {2146-6009}, address = {Selçuk Üniversitesi}, year = {2014}, volume = {4}, pages = {1 - 5}, doi = {}, title = {Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis}, key = {cite}, author = {Şahin, Şafak and Bilir, Yeliz and Taşlıyurt, Türker and Uzun Kaya, Süheyla and Kalkan, Göknur and Kutlutürk, Faruk and Öztürk, Banu and Yılmaz, Abdulkerim} }
APA Bilir, Y , Taşlıyurt, T , Kutlutürk, F , Şahin, Ş , Öztürk, B , Kalkan, G , Uzun Kaya, S , Yılmaz, A . (2014). Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis. Journal of Contemporary Medicine, 4 (1), 1-5. Retrieved from http://dergipark.gov.tr/gopctd/issue/7310/95643
MLA Bilir, Y , Taşlıyurt, T , Kutlutürk, F , Şahin, Ş , Öztürk, B , Kalkan, G , Uzun Kaya, S , Yılmaz, A . "Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis". Journal of Contemporary Medicine 4 (2014): 1-5 <http://dergipark.gov.tr/gopctd/issue/7310/95643>
Chicago Bilir, Y , Taşlıyurt, T , Kutlutürk, F , Şahin, Ş , Öztürk, B , Kalkan, G , Uzun Kaya, S , Yılmaz, A . "Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis". Journal of Contemporary Medicine 4 (2014): 1-5
RIS TY - JOUR T1 - Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis AU - Yeliz Bilir , Türker Taşlıyurt , Faruk Kutlutürk , Şafak Şahin , Banu Öztürk , Göknur Kalkan , Süheyla Uzun Kaya , Abdulkerim Yılmaz Y1 - 2014 PY - 2014 N1 - DO - T2 - Journal of Contemporary Medicine JF - Journal JO - JOR SP - 1 EP - 5 VL - 4 IS - 1 SN - -2146-6009 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Contemporary Medicine Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis %A Yeliz Bilir , Türker Taşlıyurt , Faruk Kutlutürk , Şafak Şahin , Banu Öztürk , Göknur Kalkan , Süheyla Uzun Kaya , Abdulkerim Yılmaz %T Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis %D 2014 %J Journal of Contemporary Medicine %P -2146-6009 %V 4 %N 1 %R %U
ISNAD Bilir, Yeliz , Taşlıyurt, Türker , Kutlutürk, Faruk , Şahin, Şafak , Öztürk, Banu , Kalkan, Göknur , Uzun Kaya, Süheyla , Yılmaz, Abdulkerim . "Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis". Journal of Contemporary Medicine 4 / 1 (Temmuz 2014): 1-5.