Yıl 2014, Cilt 4, Sayı 1, Sayfalar 44 - 52 2014-07-27

Sık Rastlanan Karaciğer Metastazları ve Modelleri

Ergül Eyol [1]

247 1061

The most common malignant toumors develop metastasis and are a central problem in tumor therapy The metastasis of the gastrointestinal tract is most frequently found in the liver. In the following you can see the list of various types of cancer that have spread to the liver. the frist two types of cancer. will be described in more detail. 1-Colorectal cancer 2-Pancreaticcarcinoma 3-Gastric cancer 4-Lung cancer 5-Breast cancer Each year worldwide an estimated one million new cases of colorectal cancer are diagnosed and more than half a million people died from the disease (Parkin et al. 2002). Surgical resection can offers potential tretment for colon cancer. The prognosis of patients with colon cancer dependent on the occurrence of metastases. Every year pancreatic cancer causes approximately 200.000 deaths and it is one of the most malignant types of tumors, with the poor prognosis Pancreatic carcinom has a mean survival times of 5 months. To develop new diagnostic technologies and new treatments for liver metastases the availability of a preclinical model is mandatory.

Kötü huylu tümörler çoğunlukla metastaz geliştirirler. Bu kötü huylu tümörlerin metastazları tümör tedavide hala temel bir problemdir. Sindirim sistemi kanserlerinde ise metastazlar sıklıkla karaciğere olur. Aşağıda karaciğere metastaz yapan farklı kanser tipleri sıralanmakta olup en sık metastaz yapan iki kanser türü detaylı olarak anlatılacaktır.

1-Kolorektal kanser 2-Pankreas kanser 3-Mide kanseri 4-Akciğer kanseri 5-Göğüs kanseri

Her yıl bir milyon insan kolorektal kansere yakalanmakta ve bu hastalık nedeni ile yarım milyon insan ölmektedir (Parkin ve ark.). Cerrahi müdahale ile tam bir iyileşme sağlanabilmektedir. Ancak kolon kanserli hastaların prognozu, kanserin metastaz yapıp yapmadığına bağlıdır.

Her yıl 200.000 ölüm pankreas kanseri nedeni ile gerçekleşmekte ve malign tümörler içinde prognozu en kötü olanıdır. Ortalama 5 ay gibi bir yaşama şansı vardır.

Karaciğer metastazının engellenebilmesinde yeni diagnostik teknolojiler ve yeni tedaviler geliştirebilmek için preklinik modellerin kullanılması kaçınılmazdır.

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Bibtex @ { gopctd95653, journal = {Journal of Contemporary Medicine}, issn = {}, eissn = {2146-6009}, address = {Selçuk Üniversitesi}, year = {2014}, volume = {4}, pages = {44 - 52}, doi = {}, title = {Sık Rastlanan Karaciğer Metastazları ve Modelleri}, key = {cite}, author = {Eyol, Ergül} }
APA Eyol, E . (2014). Sık Rastlanan Karaciğer Metastazları ve Modelleri. Journal of Contemporary Medicine, 4 (1), 44-52. Retrieved from http://dergipark.gov.tr/gopctd/issue/7310/95653
MLA Eyol, E . "Sık Rastlanan Karaciğer Metastazları ve Modelleri". Journal of Contemporary Medicine 4 (2014): 44-52 <http://dergipark.gov.tr/gopctd/issue/7310/95653>
Chicago Eyol, E . "Sık Rastlanan Karaciğer Metastazları ve Modelleri". Journal of Contemporary Medicine 4 (2014): 44-52
RIS TY - JOUR T1 - Sık Rastlanan Karaciğer Metastazları ve Modelleri AU - Ergül Eyol Y1 - 2014 PY - 2014 N1 - DO - T2 - Journal of Contemporary Medicine JF - Journal JO - JOR SP - 44 EP - 52 VL - 4 IS - 1 SN - -2146-6009 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Contemporary Medicine Sık Rastlanan Karaciğer Metastazları ve Modelleri %A Ergül Eyol %T Sık Rastlanan Karaciğer Metastazları ve Modelleri %D 2014 %J Journal of Contemporary Medicine %P -2146-6009 %V 4 %N 1 %R %U
ISNAD Eyol, Ergül . "Sık Rastlanan Karaciğer Metastazları ve Modelleri". Journal of Contemporary Medicine 4 / 1 (Temmuz 2014): 44-52.