Year 2015, Volume 5, Issue 1, Pages 1 - 7 2015-03-04

Is subclinical hypothyroidism increasing exogen obesity in children?
Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?

Ceyda Kırsaçlıoğlu [1] , Zeynep Şıklar [2] , Yıldız Dallar [3]

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Background: We aimed to evaluate thyroid functions and subclinical hypothyroidism in obese children.

Methods: Fourty three children with exogenous obesity and 17 aged matched idiopathic short stature children (control group) were studied with anthropometric indices and basal thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), total thyroxine (TT4) and total triiodothyronine (TT3)  levels and they all underwent thyrotropin releasing hormone (TRH) stimulation test to determine TSH response.

Results: There were no significant difference in age, bone age, basal TSH, fT3, fT4, TT4 levels between obese and control group. Total triiodothyronine levels of obese group were significantly higher than control group (p=0.009). The maximum increment of TSH levels ( TSH)  and peak TSH levels in obese group were significantly lower than the control group (p=0.021, p=0.04 respectively). We evaluated obese children for TSH response and divided them into two groups; obese group 1 ( TSH response abnormally elevated) and obese group 2 (TSH response were normal), basal TSH levels of group 1 were found significantly higher than group 2 (p<0.001).

Conclusion: Thyrotropin releasing hormone stimulation test may be helpful to determine subclinical hypothyroidism in exogen obese children, if basal TSH levels were elevated.

Key words: 

Amaç: Obez çocuklarda tiroid fonksiyonları ve subklinik hipotroidi değerlendirilmesi amaçlandı.

Gereç ve yöntemler: Kırküç obez çocuk ve kontrol grubu olarak benzer yaştaki 17 idiopatik boy kısalığı olan çocuk, antropometrik ölçümler, bazal tiroid stimule edici hormon (TSH), serbest triiodotronin (sT3), serbest tiroksin (sT4), total tiroksin (TT4), total triiodotronin (TT3) düzeyleri ve tirotropin salgılatıcı hormon (TRH) uyarı testine TSH yanıtı ile değerlendirildi.

Sonuçlar: Obez ve kontrol grubunun, yaş, kemik yaşı, bazal TSH, sT3, sT4, TT4 düzeyleri arasında fark saptanmadı. Obez grubun TT3 düzeyleri kontrol grubundan anlamlı olarak yüksekti(p=0.009). TSH düzeylerinin maksimum artışı ve pik TSH düzeyleri, obez grupta, kontrol grubuna göre anlamlı olarak düşüktü (sırasıyla p=0.021, p=0.04). Obez grup, TSH yanıtına göre değerlendirildiğinde; Grup 1 (Anormal artış gösteren TSH yanıtı olanlar) ve grup 2 (TSH yanıtı normal olanlar) olarak ikiye ayrıldı. Grup 1'in bazal TSH’sı, grup 2'den anlamlı olarak yüksekti (p<0.001).

Karar: Bazal TSH düzeyleri yüksek olan obez çocuklarda TRH uyarı testi subklinik hipotroidizmi belirlemede yardımcı olabilir.

 

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Primary Language tr
Subjects
Journal Section Original Research
Authors

Author: Ceyda Kırsaçlıoğlu

Author: Zeynep Şıklar

Author: Yıldız Dallar

Bibtex @ { gopctd95735, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Selcuk University}, year = {2015}, volume = {5}, pages = {1 - 7}, doi = {10.16899/ctd.57224}, title = {Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?}, key = {cite}, author = {Kırsaçlıoğlu, Ceyda and Şıklar, Zeynep and Dallar, Yıldız} }
APA Kırsaçlıoğlu, C , Şıklar, Z , Dallar, Y . (2015). Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?. Çağdaş Tıp Dergisi, 5 (1), 1-7. DOI: 10.16899/ctd.57224
MLA Kırsaçlıoğlu, C , Şıklar, Z , Dallar, Y . "Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?". Çağdaş Tıp Dergisi 5 (2015): 1-7 <http://dergipark.gov.tr/gopctd/issue/7315/95735>
Chicago Kırsaçlıoğlu, C , Şıklar, Z , Dallar, Y . "Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?". Çağdaş Tıp Dergisi 5 (2015): 1-7
RIS TY - JOUR T1 - Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu? AU - Ceyda Kırsaçlıoğlu , Zeynep Şıklar , Yıldız Dallar Y1 - 2015 PY - 2015 N1 - doi: 10.16899/ctd.57224 DO - 10.16899/ctd.57224 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 1 EP - 7 VL - 5 IS - 1 SN - -2146-6009 M3 - doi: 10.16899/ctd.57224 UR - https://doi.org/10.16899/ctd.57224 Y2 - 2019 ER -
EndNote %0 Çağdaş Tıp Dergisi Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu? %A Ceyda Kırsaçlıoğlu , Zeynep Şıklar , Yıldız Dallar %T Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu? %D 2015 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 5 %N 1 %R doi: 10.16899/ctd.57224 %U 10.16899/ctd.57224
ISNAD Kırsaçlıoğlu, Ceyda , Şıklar, Zeynep , Dallar, Yıldız . "Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?". Çağdaş Tıp Dergisi 5 / 1 (March 2015): 1-7. https://doi.org/10.16899/ctd.57224