Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant

Pınar TALAY PINAR [1]

120 210

This paper examined use of a boron doped diamond electrode (BDDE) for the electroanalysis of ofloxacin (one of the fluoroquinolone compounds) by cyclic voltammetry (CV) and square wave voltammetry (SWV) in the presence of anionic surfactant (SDS) for the first time. The current signal due to the oxidation process was a function of the amount of ofloxacin, pH of the medium, effect of anionic surfactant (sodium dodecyl sulfate) and scan rate. Cyclic voltammetric studies indicated an irreversible behaviour of ofloxacin in phosphate buffer solution at pH 2.0 with well-defined oxidation peak at +1.24 V (absence SDS) and +1.21 V (presence of SDS) vs. Ag/AgCl, respectively.  With optimized experimental parameters, the current response of ofloxacin was proportionally linear in the concentration range from 1.0×10-7 to 3.5×10-6 M. A detection limit of 1.76×10-8 M was observed anodically electrochemical surface pretreatments. The practical applicability of the developed method was demonstrated on the determination of ofloxacin in human urine and pharmaceutical samples. In this way, BDD electrode may represent an efficient alternative to widely used modified electrodes in the determination of fluoroquinolone compounds.

Ofloxacin, Sodium Dodecyl Sulfate, Boron-Doped Diamond Electrode, Square-Wave Voltammetry
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Konular
Dergi Bölümü Chemistry
Yazarlar

Yazar: Pınar TALAY PINAR
Ülke: Turkey


Bibtex @araştırma makalesi { gujs338968, journal = {Gazi University Journal of Science}, issn = {}, eissn = {2147-1762}, address = {Gazi Üniversitesi}, year = {}, volume = {31}, pages = {66 - 80}, doi = {}, title = {Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant}, key = {cite}, author = {TALAY PINAR, Pınar} }
APA TALAY PINAR, P . (). Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant. Gazi University Journal of Science, 31 (1), 66-80. Retrieved from http://dergipark.gov.tr/gujs/issue/35772/338968
MLA TALAY PINAR, P . "Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant". Gazi University Journal of Science 31 (): 66-80 <http://dergipark.gov.tr/gujs/issue/35772/338968>
Chicago TALAY PINAR, P . "Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant". Gazi University Journal of Science 31 (): 66-80
RIS TY - JOUR T1 - Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant AU - Pınar TALAY PINAR Y1 - 2018 PY - 2018 N1 - DO - T2 - Gazi University Journal of Science JF - Journal JO - JOR SP - 66 EP - 80 VL - 31 IS - 1 SN - -2147-1762 M3 - UR - Y2 - 2017 ER -
EndNote %0 Gazi University Journal of Science Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant %A Pınar TALAY PINAR %T Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant %D 2018 %J Gazi University Journal of Science %P -2147-1762 %V 31 %N 1 %R %U
ISNAD TALAY PINAR, Pınar . "Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant". Gazi University Journal of Science 31 / 1 66-80.