Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Fatma Gökçe APAYDIN [1] , Kaan KALTALIOĞLU [2] , Barbaros BALABANLI [3] , Şule COSKUN CEVHER [4]

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In this study, we investigated that the histopathological changes of rat kidney and liver tissues after cisplatin administration and potential beneficial effects of morin and hesperidin administration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end of the experiment and were evaluated histopathological changes. Various histopathological changes in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- and co-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxic changes in cisplatin-induced groups.

Cisplatin, Hepatotoxicity, Hesperidin, Histopathology, Morin
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Birincil Dil en
Konular Mühendislik
Dergi Bölümü Biology
Yazarlar

Yazar: Fatma Gökçe APAYDIN
Kurum: Gazi University
Ülke: Turkey


Yazar: Kaan KALTALIOĞLU
Kurum: Giresun University
Ülke: Turkey


Yazar: Barbaros BALABANLI
Kurum: Gazi University
Ülke: Turkey


Yazar: Şule COSKUN CEVHER
Kurum: Gazi University
Ülke: Turkey


Bibtex @araştırma makalesi { gujs337235, journal = {Gazi University Journal of Science}, issn = {}, eissn = {2147-1762}, address = {Gazi Üniversitesi}, year = {}, volume = {31}, pages = {399 - 406}, doi = {}, title = {Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study}, key = {cite}, author = {COSKUN CEVHER, Şule and KALTALIOĞLU, Kaan and APAYDIN, Fatma Gökçe and BALABANLI, Barbaros} }
APA APAYDIN, F , KALTALIOĞLU, K , BALABANLI, B , COSKUN CEVHER, Ş . (). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, 31 (2), 399-406. Retrieved from http://dergipark.gov.tr/gujs/issue/37206/337235
MLA APAYDIN, F , KALTALIOĞLU, K , BALABANLI, B , COSKUN CEVHER, Ş . "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study". Gazi University Journal of Science 31 (): 399-406 <http://dergipark.gov.tr/gujs/issue/37206/337235>
Chicago APAYDIN, F , KALTALIOĞLU, K , BALABANLI, B , COSKUN CEVHER, Ş . "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study". Gazi University Journal of Science 31 (): 399-406
RIS TY - JOUR T1 - Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study AU - Fatma Gökçe APAYDIN , Kaan KALTALIOĞLU , Barbaros BALABANLI , Şule COSKUN CEVHER Y1 - 2018 PY - 2018 N1 - DO - T2 - Gazi University Journal of Science JF - Journal JO - JOR SP - 399 EP - 406 VL - 31 IS - 2 SN - -2147-1762 M3 - UR - Y2 - 2018 ER -
EndNote %0 Gazi University Journal of Science Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study %A Fatma Gökçe APAYDIN , Kaan KALTALIOĞLU , Barbaros BALABANLI , Şule COSKUN CEVHER %T Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study %D 2018 %J Gazi University Journal of Science %P -2147-1762 %V 31 %N 2 %R %U
ISNAD APAYDIN, Fatma Gökçe , KALTALIOĞLU, Kaan , BALABANLI, Barbaros , COSKUN CEVHER, Şule . "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study". Gazi University Journal of Science 31 / 2 399-406.