Year 2018, Volume 38, Issue 2, Pages 65 - 75 2018-06-15

Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs

Tuğçe Boran [1] , Ayşe Tarbin Jannuzzi [2] , Buket Alpertunga [3]

40 82

ABSTRACT

Phospholipidosis is a lipid storage disorder and it is characterized by excessive

accumulation of phospholipids in tissues such as liver, kidney, brain and lung.

Accumulation of phospholipid in the cells leads to foamy cytoplasm, cytoplasmic

vacuoles and lamellar bodies which are also used as important histopathological

biomarkers of phospholipidosis. Cationic amphiphilic drugs (CADs) are known to

have a potential for development of phospholipidosis. CADs have a hydrophobic ring

structure and hydrophilic side chain which contains an amine group. Because of their

hydrophobic structure, CADs can pass through the membrans easily and get trapped

in the lysosomes thereby become cationic in the acidic environment of lysosomes.

The mechanism and the functional effects of drug induced phospholipidosis are not

fully understood. However, phospholipidosis is thought to be a toxic response due to a

probable relationship between cell death and altered cell functions, and the development

of phospholipidosis is considered as an adverse reaction.

Key words: Drug induced phospholipidosis, cationic amphiphilic drugs, drug advers

effects

ÖZET

Fosfolipidozis bir lipid depo bozukluğudur ve karaciğer, böbrek, beyin ve akciğer gibi

dokularda fosfolipidlerin aşırı birikimi ile karakterizedir. Hücrelerde fosfolipid birikimi

fosfolipidozisin önemli histopatolojik biyobelirteçleri olarak da kullanılan köpüklü

sitoplazmaya, sitoplazmik vakuollere ve lamellar cisimciklerin oluşmasına neden olur.

Katyonik amfifilik ilaçlar (KAİ’lar)’ın fosfolipidozis geliştirme potansiyellerinin olduğu

bilinmektedir. KAİ’lar hidrofobik bir halka yapısı ile amin grubu içeren hidrofilik bir

yan zincire sahiptirler. Sahip oldukları hidrofobik yapı sayesinde membranları kolaylıkla

geçerler ve lizozomların asit ortamında katyonik hale geçip lizozomlarda tutulurlar.

İlaçlar ile indüklenen fosfolipidozisin fonksiyonel olarak nasıl bir etkiye neden olduğu

ve mekanizması tam olarak bilinmemektedir. Ancak, fosfolipidozis ile değişmiş hücre

fonksiyonları ve hücre ölümü arasında olası bir ilişki bulunması nedeniyle toksik bir

yanıt oluşturduğu düşünülmekte ve fosfolipidozis gelişimi advers etki olarak kabul

edilmektedir.

Anahtar kelimeler: İlaçlar ile indüklenen fosfolipidozis, katyonik amfifilik ilaçlar, ilaç

advers etkileri

Drug induced phospholipidosis, cationic amphiphilic drugs
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Primary Language tr
Subjects
Journal Section Review Articles
Authors

Author: Tuğçe Boran
Institution: ISTANBUL UNIVERSITY
Country: Turkey


Author: Ayşe Tarbin Jannuzzi
Institution: ISTANBUL UNIVERSITY
Country: Turkey


Author: Buket Alpertunga (Primary Author)
Institution: ISTANBUL UNIVERSITY
Country: Turkey


Bibtex @review { hujpharm500283, journal = {Hacettepe University Journal of the Faculty of Pharmacy}, issn = {}, eissn = {2458-8806}, address = {Hacettepe Üniversitesi Eczacılık Fakültesi}, year = {2018}, volume = {38}, pages = {65 - 75}, doi = {}, title = {Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs}, key = {cite}, author = {Boran, Tuğçe and Tarbin Jannuzzi, Ayşe and Alpertunga, Buket} }
APA Boran, T , Tarbin Jannuzzi, A , Alpertunga, B . (2018). Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs. Hacettepe University Journal of the Faculty of Pharmacy, 38 (2), 65-75. Retrieved from http://dergipark.gov.tr/hujpharm/issue/41389/500283
MLA Boran, T , Tarbin Jannuzzi, A , Alpertunga, B . "Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs". Hacettepe University Journal of the Faculty of Pharmacy 38 (2018): 65-75 <http://dergipark.gov.tr/hujpharm/issue/41389/500283>
Chicago Boran, T , Tarbin Jannuzzi, A , Alpertunga, B . "Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs". Hacettepe University Journal of the Faculty of Pharmacy 38 (2018): 65-75
RIS TY - JOUR T1 - Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs AU - Tuğçe Boran , Ayşe Tarbin Jannuzzi , Buket Alpertunga Y1 - 2018 PY - 2018 N1 - DO - T2 - Hacettepe University Journal of the Faculty of Pharmacy JF - Journal JO - JOR SP - 65 EP - 75 VL - 38 IS - 2 SN - -2458-8806 M3 - UR - Y2 - 2017 ER -
EndNote %0 Hacettepe University Journal of the Faculty of Pharmacy Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs %A Tuğçe Boran , Ayşe Tarbin Jannuzzi , Buket Alpertunga %T Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs %D 2018 %J Hacettepe University Journal of the Faculty of Pharmacy %P -2458-8806 %V 38 %N 2 %R %U
ISNAD Boran, Tuğçe , Tarbin Jannuzzi, Ayşe , Alpertunga, Buket . "Drug Induced Phospholipidosis and Cationic Amphiphilic Drugs". Hacettepe University Journal of the Faculty of Pharmacy 38 / 2 (June 2018): 65-75.