Yıl 2018, Cilt 4, Sayı 3, Sayfalar 149 - 153 2018-10-14

Boy uzunluğu ve kanser ilişkisi

Aslıhan İleri [1] , Zeynep Akbaş [2] , Beyza Yıldırım [3] , Oytun Erbaş [4]

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İnsülin benzeri büyüme faktörü (IGF) sistemi, IGF-1, IGF-2 ligandları, membran reseptörleri ve bağlanma proteinlerinden (IGFBP) oluşan önemli biyolojik mekanizmalardan biridir. İnsülin benzeri büyüme faktörü sistemi, birçok spesifik hücrede büyümeyi sağlar. Büyüme hormonunun (GH) biyolojik etkileri olan postnatal gelişim ve longitudinal büyüme, GH stimülasyonu ile karaciğerden sentezlenen IGF-1 üzerinden gerçekleşir. IGF-1, kemik ve iskelet kasında da sentezlenen bir peptiddir. Bu etkisiyle boy uzamasında rol oynar. İnsülin benzeri büyüme faktörü sistemi aynı zamanda hücresel döngüde hücre proliferasyonunu ilerletir, regüle eder ve apoptozisi inhibe eder. Tüm bu etkiler hücresel döngüde mutasyona uğramış hücrelerin devamlı bölünmesine olanak sağlayarak kanser oluşumuna yol açar. Genom çapındaki bu bağlantılar boy ve kanser arasındaki ilişkinin ortaya çıkmasına olanak sağlamıştır. Yapılan bazı araştırmalarda birçok kanser türü ile boy uzunluğu arasında anlamlı pozitif ilişki görülür iken, bazı çalışmalarda ise bu sonuç elde edilememiştir.

Apoptoz, kanser riski, hücre bölünmesi, boy uzunluğu, insülin benzeri büyüme faktörü
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Birincil Dil tr
Konular
Dergi Bölümü Derleme
Yazarlar

Yazar: Aslıhan İleri

Yazar: Zeynep Akbaş

Yazar: Beyza Yıldırım

Yazar: Oytun Erbaş (Sorumlu Yazar)

Bibtex @derleme { ibufntd470404, journal = {İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi}, issn = {2149-4401}, eissn = {2547-9466}, address = {Bayçınar Tıbbi Yayıncılık ve Reklam Hiz. Tic. Ltd. Şti.}, year = {2018}, volume = {4}, pages = {149 - 153}, doi = {}, title = {Boy uzunluğu ve kanser ilişkisi}, key = {cite}, author = {Akbaş, Zeynep and Erbaş, Oytun and Yıldırım, Beyza and İleri, Aslıhan} }
APA İleri, A , Akbaş, Z , Yıldırım, B , Erbaş, O . (2018). Boy uzunluğu ve kanser ilişkisi. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 4 (3), 149-153. Retrieved from http://dergipark.gov.tr/ibufntd/issue/39718/470404
MLA İleri, A , Akbaş, Z , Yıldırım, B , Erbaş, O . "Boy uzunluğu ve kanser ilişkisi". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 (2018): 149-153 <http://dergipark.gov.tr/ibufntd/issue/39718/470404>
Chicago İleri, A , Akbaş, Z , Yıldırım, B , Erbaş, O . "Boy uzunluğu ve kanser ilişkisi". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 (2018): 149-153
RIS TY - JOUR T1 - Boy uzunluğu ve kanser ilişkisi AU - Aslıhan İleri , Zeynep Akbaş , Beyza Yıldırım , Oytun Erbaş Y1 - 2018 PY - 2018 N1 - DO - T2 - İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi JF - Journal JO - JOR SP - 149 EP - 153 VL - 4 IS - 3 SN - 2149-4401-2547-9466 M3 - UR - Y2 - 2018 ER -
EndNote %0 İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi Boy uzunluğu ve kanser ilişkisi %A Aslıhan İleri , Zeynep Akbaş , Beyza Yıldırım , Oytun Erbaş %T Boy uzunluğu ve kanser ilişkisi %D 2018 %J İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi %P 2149-4401-2547-9466 %V 4 %N 3 %R %U
ISNAD İleri, Aslıhan , Akbaş, Zeynep , Yıldırım, Beyza , Erbaş, Oytun . "Boy uzunluğu ve kanser ilişkisi". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 / 3 (Ekim 2018): 149-153.