Yıl 2018, Cilt 4, Sayı 3, Sayfalar 115 - 122 2018-10-14

Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy

Handan Tanyıldızı [1] , Mustafa Demir [2] , Baki Akkuş [3]

9 16

Objectives: This study aims to detect the maximum permissible activity (MPA) in patients with unresectable liver metastasis and hepatocellular carcinoma treated with Yttrium-90 (Y-90) microspheres and to evaluate the absorbed radiation doses with patient-specific dosimetry methods.

Materials and methods: A total of 31 patients (20 males, 11 females; mean age 47±0.2 years; range, 32 to 62 years) were applied dosimetry. Empiric, body surface area (BSA), Medical Internal Radiation Dose (MIRD) and partition internal dosimetry models were used to calculate the MPA to deliver the maximum absorbable dose to the tumor while reducing the absorbed dose by the critical organs.

Results: Mean Y-90 activity was 57483±7.7 megabecquerel (MBq) for empiric model, 1806.04±1.37 MBq for BSA, 1649.60±1.3 MBq for MIRD, and 1658.71 MBq for partition. Mean absorbed dose calculated according to empiric model was 40.14±0.20, 197.62±0.45 and 7.39±0.08 gray (Gy) for normal liver, tumor and lung, respectively. Mean absorbed dose calculated according to BSA was 33.61±0.18, 167.83±0.41, 6.39±0.08 Gy for normal liver, tumor and lung, respectively. Mean absorbed dose calculated according to MIRD was 29.63±0.17, 125.62±0.36 and 5.67±0.07 Gy for normal liver, tumor and lung, respectively. Mean absorbed dose calculated according to partition model was 29.82±0.17, 126.72±0.36 and 5.72±0.07 Gy for normal liver, tumor and lung, respectively.

Conclusion: Since the MPAs calculated according to empiric and BSA models will lead to organ toxicity by forming high amounts of absorbed doses at critical organs, these models are not appropriate approaches for dosimetry. On the other hand, MIRD and partition models are the most successful methods for internal dosimetry applications.

Internal dosimetry, radionuclide therapy, Yttrium-90
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Orcid: 0000-0001-5231-2768
Yazar: Handan Tanyıldızı (Sorumlu Yazar)

Orcid: 0000-0002-9813-1628
Yazar: Mustafa Demir

Orcid: 0000-0002-9533-7671
Yazar: Baki Akkuş

Bibtex @araştırma makalesi { ibufntd470410, journal = {İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi}, issn = {2149-4401}, eissn = {2547-9466}, address = {Bayçınar Tıbbi Yayıncılık ve Reklam Hiz. Tic. Ltd. Şti.}, year = {2018}, volume = {4}, pages = {115 - 122}, doi = {}, title = {Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy}, key = {cite}, author = {Demir, Mustafa and Tanyıldızı, Handan and Akkuş, Baki} }
APA Tanyıldızı, H , Demir, M , Akkuş, B . (2018). Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 4 (3), 115-122. Retrieved from http://dergipark.gov.tr/ibufntd/issue/39718/470410
MLA Tanyıldızı, H , Demir, M , Akkuş, B . "Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 (2018): 115-122 <http://dergipark.gov.tr/ibufntd/issue/39718/470410>
Chicago Tanyıldızı, H , Demir, M , Akkuş, B . "Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 (2018): 115-122
RIS TY - JOUR T1 - Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy AU - Handan Tanyıldızı , Mustafa Demir , Baki Akkuş Y1 - 2018 PY - 2018 N1 - DO - T2 - İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi JF - Journal JO - JOR SP - 115 EP - 122 VL - 4 IS - 3 SN - 2149-4401-2547-9466 M3 - UR - Y2 - 2018 ER -
EndNote %0 İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy %A Handan Tanyıldızı , Mustafa Demir , Baki Akkuş %T Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy %D 2018 %J İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi %P 2149-4401-2547-9466 %V 4 %N 3 %R %U
ISNAD Tanyıldızı, Handan , Demir, Mustafa , Akkuş, Baki . "Detecting the optimal patient-specific radiation dosimetry in Yttrium-90 microsphere therapy". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 4 / 3 (Ekim 2018): 115-122.