Cilt 5, Sayı 1, Sayfalar 1 - 6 2017-08-21

Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae)

Nazim A. Mamedov [1] , Ardalan Pasdaran [2] , Nilufer Z. Mamadalieva Mamadalieva [3]

82 51

Syrian rue (Peganum harmala L., Zygophyllaceae) has been used in traditional medicine of Central Asia, the Middle East, and Caucasus areas (Azerbaijan) for centuries, mainly as ritual and psychedelic plant.  At full growth, this erect, dichotomously branched shrub is about 1 m in height with a dense foliage consisting of narrow, linear, pinnate leaves with acute spreading lobes, and small solitary, axillary, white flowers and globe capsules enclosing numerous angular seeds.  All parts of the plant (including roots) contain alkaloids.  The seeds contain β-carbolineses (harmine, harmalol and harman) with the active hallucinogen being the alkaloid harmine.  The seeds contain a red pigment used for coloring wool and carpets and for use as a spice and, in traditional medicine, as valuable aphrodisiac.

pharmacological studies,Syrian rue,Peganum harmala L.,Zygophyllaceae
  • Shultes, E. (1976). Hallucinogenic plants, Golden Press, New York
  • Damirov, I.A., Prilipko L.I., Shukurov J.Z., and J.B.Kerimov. (1983). Medicinal plants of Azerbaijan, Maarif, Baku (in Russian)
  • Muravyova, D.A. (1991). Pharmacognosy, Medicina, Moscow (in Russian)
  • Khalmatov, H.H., Kharlamov I.A., and Z.I. Mavlankulova, (1998). Medicinal plants of Central Asia, Ibn Sina Press, Tashkent (in Russian)
  • Kapoor, L.D. (2001). Handbook of Ayurvedic Medicinal Plants, CRC Press
  • Daniel, M. (2006). Medicinal Plants:Chemistry and Properties, Science Publishers, Enfield, NH, USA
  • Shahverdi, A. R., H.R.Monsef-Esfahani, B.Nikavar, L. Bitarafan, S. Khodaee, N.Khoshakhlagh (2005). Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Zeitschrift für Naturforschung, 60(9-10): 707-710.
  • Alakbarli, F. (2006). Medical Manuscripts of Azerbaijan, Heydar Aliyev Foundation, Baku
  • Berrougui, H.; Martín-Cordero, C.; Khalil, A.; Hmamouchi, M.; Ettaib, A.; Marhuenda, E.; Herrera, M. D.(2006). Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta. Pharmacological Research, 54, 150-157.
  • Jbilou, R.; Amri, H.; Bouayad, N.; Ghailani, N.; Ennabili, A.; Sayah, F.(2008). Insecticidal effects of extracts of seven plant species on larval development, alpha-amylase activity and offspring production of Tribolium castaneum (Herbst) (Insecta: Coleoptera: Tenebrionidae). Bioresour. Technology, 99, 959-964.
  • Agedilova, M. T.; Turmukhambetov, A. Z.,; Schultz, E. E.; Shakirov, M. M.; Adekenov, S. M. (2006). Components of the aerial part of Peganum harmala. Chemistry of Natural Compounds, 42, 226-227.
  • Somer E., (1992). The essential Guide to Vitamins and Minerals, NY: Harper Collins Publishers, New York
  • Bourke, C.A., M.J.Carrigan, R.J. Dixon (1990). Upper motor neurone effects in sheep of some beta‐carboline alkaloids identified in zygophyllaceous plants. Australian veterinary journal, 67(7): 248-251.
  • Herraiz T., González D., Ancin-Azpilicueta C., Arán V.J., Guillén H. (2010). β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48 (3): 839-845.
  • Farzin, D., et al. (2011). Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat. Pharmacology Biochemistry and Behavior, 98(2): 215-219.
  • Youdim, M. B. and M. Weinstock (2004). Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation. Neurotoxicology, 25(1): 243-250.
  • Herraiz, T. and C. Chaparro (2005). Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors. Biochemical and biophysical research communications, 326(2): 378-386.
  • Youdim, M. B., D, Edmondson, K.F. Tipton (2006). The therapeutic potential of monoamine oxidase inhibitors. Nature Reviews Neuroscience, 7 (4): 295-309.
  • Murray, M. (1996). Encyclopedia of Nutritional Supplements. Prima Publishing
  • Mamedov N., Aliyeva S., and T Musayeva, (1994). Syrian rue in traditional herbal medicine of Azerbaijan (independent study project), National Academy of Sciences, Institute of Botany, Baku (in Russian)
  • Tahraoui, A.; El-Hilaly, J.; Israili, Z. H.; Lyoussi, B. (2007). Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J. Ethnopharmacol., 110, 105-117.
  • Farouk, L.; Laroubi, A.; Aboufatima, R.; Benharref, A.; Chait, A. (2008). Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J. Ethnopharmacol., 115, 449-454
  • Jahaniani, F.; Ebrahimi, S. A.; Rahbar-Roshandel, N.; Mahmoudian, M.(2005). Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry, 66, 1581-1592.
  • Baum, S. S., R.Hill, H. Rommelspacher (1996). Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats. European journal of pharmacology, 314(1): 75-82.
  • Grella, B., M. Dukat, R. Younga, M. Teitlerb, K. Henrick-Davisb, C.B. Gauthierb, R.A. Glennon (1998). Investigation of hallucinogenic and related β-carbolines. Drug and Alcohol dependence, 50(2): 99-107.
  • Glennon, R. A., M. Dukat, B. Grella, Seoung-Soo Hong, L. Constantino, M. Teitler, C. Smith, C. Egan, K. Davis, M. Mattson (2000). Binding of β-carbolines and related agents at serotonin (5-HT 2 and 5-HT 1A), dopamine (D 2) and benzodiazepine receptors. Drug and Alcohol dependence, 60(2): 121-132.
  • Stephens, D., H.H. Schneider, W. Kehr, Jensen L.N., Petersen E., Honore T. (1987). Modulation of anxiety by β-carbolines and other benzodiazepine receptor ligands: relationship of pharmacological to biochemical measures of efficacy. Brain research bulletin, 19(3): 309-318.
  • Brush, D. E., S.B. Bird, E.W.Boyer (2004). Monoamine oxidase inhibitor poisoning resulting from Internet misinformation on illicit substances. Journal of Toxicology: Clinical Toxicology, 42(2): 191-195.
Konular Biyoloji
Yayımlanma Tarihi January
Dergi Bölümü Makaleler
Yazarlar

Orcid: https://orcid.org/0000-0003-4235-5072
Yazar: Nazim A. Mamedov
E-posta: mamedov@cas.umass.edu
Kurum: University of Massachusetts
Ülke: United States


Yazar: Ardalan Pasdaran
E-posta: ardalan.pasdaran@yahoo.com
Kurum: Shiraz University of Medical Sciences
Ülke: Iran


Orcid: https://orcid.org/0000-0003-1756-3638
Yazar: Nilufer Z. Mamadalieva Mamadalieva
E-posta: mnilufar76@yahoo.com
Kurum: Uzbekistan Academy of Sciences
Ülke: Uzbekistan


Bibtex @araştırma makalesi { ijsm335539, journal = {International Journal of Secondary Metabolite}, issn = {}, address = {İzzet KARA}, year = {2017}, volume = {5}, pages = {1 - 6}, doi = {10.21448/ijsm.335539}, title = {Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae)}, language = {en}, key = {cite}, author = {Mamadalieva, Nilufer Z. Mamadalieva and Mamedov, Nazim A. and Pasdaran, Ardalan} }
APA Mamedov, N , Pasdaran, A , Mamadalieva, N . (2017). Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae). International Journal of Secondary Metabolite, 5 (1), 1-6. DOI: 10.21448/ijsm.335539
MLA Mamedov, N , Pasdaran, A , Mamadalieva, N . "Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae)". International Journal of Secondary Metabolite 5 (2017): 1-6 <http://dergipark.gov.tr/ijsm/issue/30958/335539>
Chicago Mamedov, N , Pasdaran, A , Mamadalieva, N . "Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae)". International Journal of Secondary Metabolite 5 (2017): 1-6
RIS TY - JOUR T1 - Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae) AU - Nazim A. Mamedov , Ardalan Pasdaran , Nilufer Z. Mamadalieva Mamadalieva Y1 - 2017 PY - 2017 N1 - doi: 10.21448/ijsm.335539 DO - 10.21448/ijsm.335539 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 1 EP - 6 VL - 5 IS - 1 SN - -2148-6905 M3 - doi: 10.21448/ijsm.335539 UR - http://dx.doi.org/10.21448/ijsm.335539 Y2 - 2017 ER -
EndNote %0 International Journal of Secondary Metabolite Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae) %A Nazim A. Mamedov , Ardalan Pasdaran , Nilufer Z. Mamadalieva Mamadalieva %T Pharmacological Studies of Syrian Rue (Peganum harmala L., Zygophyllaceae) %D 2017 %J International Journal of Secondary Metabolite %P -2148-6905 %V 5 %N 1 %R doi: 10.21448/ijsm.335539 %U 10.21448/ijsm.335539