Yıl 2018, Cilt 5, Sayı 1, Sayfalar 49 - 59 2017-12-14

The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model

Mehmet İbrahim Tuğlu [1] , Işıl Aydemir [2] , Pınar Kılıçarslan Sönmez [3] , Tahir Buran [4] , Mesut Mete [5]

200 166

The use of medicinal plants as an alternative treatment is a historical process and has been known for a long time so that classical treatment can be more effective in wound and cancer treatment. The purpose of this study was to investigate the effects of plant extracts used for therapeutic purposes in cancer cell lines in vitro wound model and in vivo experimental animal model in order to obtain this information. The plants, olive oil (Oleocanthal), mistletoe (Viscum album), Common Centaury (Centaurium erythraea), Momordica charantia, Inula viscosa, Citrus aurantium, Thyme oil (Thymus vulgaris) and algae (Jania longifurca), were used. MCF-7, MB-MDA-231, 67NR and 4T1 for breast, NB2a for neuron, L929 for fibroblast and normal somatic mesenchymal stem cell for comparison were selected for in vitro wound models. As an in vivo breast cancer model, female Balb/c mice were injected with 4T1 cells and skin wound healing in rats was investigated. The effects of medicinal plants were evaluated using MTT assay for viability and proliferation, immunocytochemistry staining NOS for oxidative stress and TGFbeta1 for wound healing. It was found that plant extracts reduced antioxidative damage and inhibited apoptosis. It was observed that oxidative stress and apoptosis were increased in cancer cells, but less effective in invasive cell lines. In vivo experiments showed that wound healing was accelerated and that these rates were achieved with antioxidative and antiapoptotic effects. It has been concluded that medicinal plants are beneficial for treatment of difficult diseases in which patient quality of life is very effective and they should be used as scientific-based medical applications.

Medicinal plants, cancer cell lines, experimental animal model, alternative therapy
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Konular Biyoloji
Yayımlanma Tarihi January
Dergi Bölümü Makaleler
Yazarlar

Orcid: orcid.org/0000-0002-0569-8415
Yazar: Mehmet İbrahim Tuğlu (Sorumlu Yazar)
Kurum: CELÂL BAYAR ÜNİVERSİTESİ

Orcid: orcid.org/0000-0002-4143-7319
Yazar: Işıl Aydemir
Kurum: NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ

Orcid: orcid.org/0000-0002-9413-1735
Yazar: Pınar Kılıçarslan Sönmez
Kurum: CELÂL BAYAR ÜNİVERSİTESİ

Orcid: orcid.org/0000-0002-8077-2582
Yazar: Tahir Buran
Kurum: CELÂL BAYAR ÜNİVERSİTESİ

Orcid: orcid.org/0000-0002-7182-2955
Yazar: Mesut Mete
Kurum: CELÂL BAYAR ÜNİVERSİTESİ

Bibtex @araştırma makalesi { ijsm365065, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {İzzet KARA}, year = {2017}, volume = {5}, pages = {49 - 59}, doi = {10.21448/ijsm.365065}, title = {The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model}, key = {cite}, author = {Buran, Tahir and Kılıçarslan Sönmez, Pınar and Mete, Mesut and Tuğlu, Mehmet İbrahim and Aydemir, Işıl} }
APA Tuğlu, M , Aydemir, I , Kılıçarslan Sönmez, P , Buran, T , Mete, M . (2017). The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model. International Journal of Secondary Metabolite, 5 (1), 49-59. DOI: 10.21448/ijsm.365065
MLA Tuğlu, M , Aydemir, I , Kılıçarslan Sönmez, P , Buran, T , Mete, M . "The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model". International Journal of Secondary Metabolite 5 (2017): 49-59 <http://dergipark.gov.tr/ijsm/issue/30958/365065>
Chicago Tuğlu, M , Aydemir, I , Kılıçarslan Sönmez, P , Buran, T , Mete, M . "The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model". International Journal of Secondary Metabolite 5 (2017): 49-59
RIS TY - JOUR T1 - The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model AU - Mehmet İbrahim Tuğlu , Işıl Aydemir , Pınar Kılıçarslan Sönmez , Tahir Buran , Mesut Mete Y1 - 2017 PY - 2017 N1 - doi: 10.21448/ijsm.365065 DO - 10.21448/ijsm.365065 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 49 EP - 59 VL - 5 IS - 1 SN - -2148-6905 M3 - doi: 10.21448/ijsm.365065 UR - http://dx.doi.org/10.21448/ijsm.365065 Y2 - 2017 ER -
EndNote %0 International Journal of Secondary Metabolite The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model %A Mehmet İbrahim Tuğlu , Işıl Aydemir , Pınar Kılıçarslan Sönmez , Tahir Buran , Mesut Mete %T The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model %D 2017 %J International Journal of Secondary Metabolite %P -2148-6905 %V 5 %N 1 %R doi: 10.21448/ijsm.365065 %U 10.21448/ijsm.365065
ISNAD Tuğlu, Mehmet İbrahim , Aydemir, Işıl , Kılıçarslan Sönmez, Pınar , Buran, Tahir , Mete, Mesut . "The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model". International Journal of Secondary Metabolite 5 / 1 (Aralık 2017): 49-59. http://dx.doi.org/10.21448/ijsm.365065