Yıl 2018, Cilt 5, Sayı 3, Sayfalar 224 - 232 2018-09-15

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain

Afag M Rashidova [1]

26 51

The effect of hypoxic hypoxia on the pyruvate kinase (PK) activity in the brain structures of white rats during ontogenesis in a comparative aspect has been studied. A clear dependence could be established in the increase of PK activity from an oxygen deficient state, the age of animals, the studied structure of the brain and the prolonged effect of hypoxia. Prenatal exposure to hypoxia has shown that the PK activity is not restored to the control value level in postnatal development. After postnatal exposure to hypoxia with increasing age in animals, the PK activity gets more resistant to the effect of stress-factors. The data analysis indicates that the increasing exhaustion of energy resources necessary for normal cell functioning makes an important contribution to the development of hypoxic state and the insufficiency of mitochondrial oxidative phosphorylation, the main energy forming system which underlies these disturbances. Energy-shortage, in its turn causes a variety of secondary negative metabolic alterations and gives rise to free radical oxidation in the cells. An explanation of the obtained results suggested can be considered as an evidence of the realization of the biological effect of hypoxia through the oxidative mechanism.

Albino rats, Age, Hypoxia, Brain, Ontogenesis, Pyruvate kinase (PK)
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Birincil Dil en
Konular Biyoloji
Yayımlanma Tarihi September
Dergi Bölümü Makaleler
Yazarlar

Orcid: 0000-0002-1452-3086
Yazar: Afag M Rashidova (Sorumlu Yazar)
Ülke: Azerbaijan


Bibtex @araştırma makalesi { ijsm450963, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {İzzet KARA}, year = {2018}, volume = {5}, pages = {224 - 232}, doi = {10.21448/ijsm.450963}, title = {Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain}, key = {cite}, author = {Rashidova, Afag M} }
APA Rashidova, A . (2018). Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain. International Journal of Secondary Metabolite, 5 (3), 224-232. DOI: 10.21448/ijsm.450963
MLA Rashidova, A . "Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain". International Journal of Secondary Metabolite 5 (2018): 224-232 <http://dergipark.gov.tr/ijsm/issue/37294/450963>
Chicago Rashidova, A . "Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain". International Journal of Secondary Metabolite 5 (2018): 224-232
RIS TY - JOUR T1 - Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain AU - Afag M Rashidova Y1 - 2018 PY - 2018 N1 - doi: 10.21448/ijsm.450963 DO - 10.21448/ijsm.450963 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 224 EP - 232 VL - 5 IS - 3 SN - -2148-6905 M3 - doi: 10.21448/ijsm.450963 UR - http://dx.doi.org/10.21448/ijsm.450963 Y2 - 2018 ER -
EndNote %0 International Journal of Secondary Metabolite Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain %A Afag M Rashidova %T Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain %D 2018 %J International Journal of Secondary Metabolite %P -2148-6905 %V 5 %N 3 %R doi: 10.21448/ijsm.450963 %U 10.21448/ijsm.450963
ISNAD Rashidova, Afag M . "Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain". International Journal of Secondary Metabolite 5 / 3 (Eylül 2018): 224-232. http://dx.doi.org/10.21448/ijsm.450963