Yıl 2018, Cilt 5, Sayı 4, Sayfalar 319 - 330 2018-12-29

Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages
Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages

Mehmet Varol [1]

14 16

Pulvinic acid derivatives are considered as worthy to be evaluated as skin protection factor toward ultraviolet-induced damages because of their colors and locations in lichens. Due to the lack of literature about photo-protective features of pulvinic acid derivatives, their cosmetic potentials for skin protection were evaluated in silico, for the first time. Computational chemistry, biology and pharmacology platforms such as Gaussian, GAMESS, PASS, PaDEL-DDPredictor and VEGA QSAR platforms were employed to determine the activities of pulvinic acid derivatives. Pulvinic acid derivatives were divided into three groups as the most promising, promising and unpromising compounds according to the calculated p-values. Although leprapinic acid, demethylleprapinic acid, pinastric acid, leprapinic acid methyl ether, 4-hydroxyvulpinic acid and vulpinic acid were determined as the most promising compounds, epanorin and rhizocarpic acid were identified as promising compounds. The proposed model seems to be reliable because the calculated p-value for vulpinic acid was found to be compatible with previously obtained experimental results. The pulvinic acid derivatives that were identified as the most promising ones should be therefore further studied by in vitro and in vivo multiple experiments.

Pulvinic acid derivatives are considered as worthy to be evaluated as skin protection factor toward ultraviolet-induced damages because of their colors and locations in lichens. Due to the lack of literature about photo-protective features of pulvinic acid derivatives, their cosmetic potentials for skin protection were evaluated in silico, for the first time. Computational chemistry, biology and pharmacology platforms such as Gaussian, GAMESS, PASS, PaDEL-DDPredictor and VEGA QSAR platforms were employed to determine the activities of pulvinic acid derivatives. Pulvinic acid derivatives were divided into three groups as the most promising, promising and unpromising compounds according to the calculated p-values. Although leprapinic acid, demethylleprapinic acid, pinastric acid, leprapinic acid methyl ether, 4-hydroxyvulpinic acid and vulpinic acid were determined as the most promising compounds, epanorin and rhizocarpic acid were identified as promising compounds. The proposed model seems to be reliable because the calculated p-value for vulpinic acid was found to be compatible with previously obtained experimental results. The pulvinic acid derivatives that were identified as the most promising ones should be therefore further studied by in vitro and in vivo multiple experiments.

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Birincil Dil en
Konular Biyoloji
Yayımlanma Tarihi December
Dergi Bölümü Makaleler
Yazarlar

Orcid: 0000-0003-2565-453X
Yazar: Mehmet Varol (Sorumlu Yazar)
Kurum: Mugla Sitki Kocman University
Ülke: Turkey


Bibtex @araştırma makalesi { ijsm457412, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {İzzet KARA}, year = {2018}, volume = {5}, pages = {319 - 330}, doi = {10.21448/ijsm.457412}, title = {Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages}, key = {cite}, author = {Varol, Mehmet} }
APA Varol, M . (2018). Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages. International Journal of Secondary Metabolite, 5 (4), 319-330. DOI: 10.21448/ijsm.457412
MLA Varol, M . "Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages". International Journal of Secondary Metabolite 5 (2018): 319-330 <http://dergipark.gov.tr/ijsm/issue/39967/457412>
Chicago Varol, M . "Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages". International Journal of Secondary Metabolite 5 (2018): 319-330
RIS TY - JOUR T1 - Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages AU - Mehmet Varol Y1 - 2018 PY - 2018 N1 - doi: 10.21448/ijsm.457412 DO - 10.21448/ijsm.457412 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 319 EP - 330 VL - 5 IS - 4 SN - -2148-6905 M3 - doi: 10.21448/ijsm.457412 UR - http://dx.doi.org/10.21448/ijsm.457412 Y2 - 2018 ER -
EndNote %0 International Journal of Secondary Metabolite Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages %A Mehmet Varol %T Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages %D 2018 %J International Journal of Secondary Metabolite %P -2148-6905 %V 5 %N 4 %R doi: 10.21448/ijsm.457412 %U 10.21448/ijsm.457412
ISNAD Varol, Mehmet . "Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages". International Journal of Secondary Metabolite 5 / 4 (Aralık 2018): 319-330. http://dx.doi.org/10.21448/ijsm.457412