Cilt 47, Sayı 1, Sayfalar 5 - 8

Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides

Bahar Ulus [1] , Müzeyyen Çeliksöz [2] , Gül Özhan [3]

54 52

Human populations are exposed to several toxic substances in the environment, including pesticides. Fenoxaprop-p-ethyl (FPE) and fluzifob-p-butyl (FPB) herbicides are extensively used in agricultural fields due to their high target selectivity and low non-target toxicity. They are known as aryloxyphenoxypropionate herbicides, and acetyl-CoA carboxylase inhibitor. In the study, we aimed to evaluate the toxic potentials of FPE and FPB herbicides. Cell viability was evaluated by MTT assay in the range of 15.6-500.0 µM exposure concentrations in mouse fibroblast (BALB/3T3) cell line. Also, we investigated their DNA damage potentials on BALB/3T3 cells by using alkaline Comet assay. The results indicated that FPE and FPB showed no evidence of DNA damage. And, the cell viability was more than 20% at 12.5-400 µM exposure concentrations. FPE and FPB might be safe according to our results and the previously studies, and there would be public health benefits from encouraging its use in the place of more toxic herbicide products. 

Fenoxaprop-p-ethyl,fluzifob-p-butyl
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Konular Farmakoloji ve Eczacılık
Dergi Bölümü Original Article
Yazarlar

Yazar: Bahar Ulus
E-posta: baharulus.ecz@hotmail.com
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
Ülke: Turkey


Yazar: Müzeyyen Çeliksöz
E-posta: muzeyyen.celiksoz@gmail.com
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
Ülke: Turkey


Yazar: Gül Özhan
E-posta: gulozhan@istanbul.edu.tr
Kurum: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
Ülke: Turkey


Bibtex @araştırma makalesi { iujp332009, journal = {Istanbul Journal of Pharmacy}, issn = {2548-0731}, address = {İstanbul Üniversitesi}, year = {}, volume = {47}, pages = {5 - 8}, doi = {10.5152/IstanbulJPharm.2017.002}, title = {Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides}, language = {en}, key = {cite}, author = {Çeliksöz, Müzeyyen and Özhan, Gül and Ulus, Bahar} }
APA Ulus, B , Çeliksöz, M , Özhan, G . (). Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides. Istanbul Journal of Pharmacy, 47 (1), 5-8. DOI: 10.5152/IstanbulJPharm.2017.002
MLA Ulus, B , Çeliksöz, M , Özhan, G . "Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides". Istanbul Journal of Pharmacy 47 (): 5-8 <http://dergipark.gov.tr/iujp/issue/30716/332009>
Chicago Ulus, B , Çeliksöz, M , Özhan, G . "Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides". Istanbul Journal of Pharmacy 47 (): 5-8
RIS TY - JOUR T1 - Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides AU - Bahar Ulus , Müzeyyen Çeliksöz , Gül Özhan Y1 - 2017 PY - 2017 N1 - doi: 10.5152/IstanbulJPharm.2017.002 DO - 10.5152/IstanbulJPharm.2017.002 T2 - Istanbul Journal of Pharmacy JF - Journal JO - JOR SP - 5 EP - 8 VL - 47 IS - 1 SN - 2548-0731- M3 - doi: 10.5152/IstanbulJPharm.2017.002 UR - http://dx.doi.org/10.5152/IstanbulJPharm.2017.002 Y2 - 2017 ER -
EndNote %0 Istanbul Journal of Pharmacy Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides %A Bahar Ulus , Müzeyyen Çeliksöz , Gül Özhan %T Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides %D 2017 %J Istanbul Journal of Pharmacy %P 2548-0731- %V 47 %N 1 %R doi: 10.5152/IstanbulJPharm.2017.002 %U 10.5152/IstanbulJPharm.2017.002