Yıl 2009, Cilt 24, Sayı 2, Sayfalar 80 - 84 2014-08-16

Osteoklast benzeri dev hücreler içeren faringeal skuamöz hücreli karsinom: Olgu sunumu ve literatürün gözden geçirilmesi
Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature

Nilüfer Onak KANDEMİR [1] , Sibel BEKTAŞ [2] , Gamze YURDAKAN [3] , Ebru TAŞ [4]

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Benign osteoclast-like multinuclear giant cells are rarely found in tumors other than bone and soft tissue neoplasms, and they are even rarer in squamous cell carcinomas. We examined a nasopharyngeal tumor from a 52-year-old female who had undergone surgery one year earlier for hypopharyngeal squamous cell carcinoma. Histopathologically, in addition to tumor infiltration by atypical epithelial cells with squamoid differentiation, giant cells with 10-20 nuclei and a large amount of eosinophilic cytoplasm were seen infiltrating the tumor. The giant cells did not show atypia or mitosis. Immunohistochemically, the tumor cells stained for pan-keratin and epithelial membrane antigen, and the giant cells were positive for leukocyte common antigen, CD68, and Mac 387. This case was diagnosed as moderately differentiated squamous cell carcinoma with multinuclear giant cells. In this case, the giant cells infiltrating the tumor were benign and of monocytic/histiocytic origin. Studies including large case series are needed to obtain reliable information on the clinical and prognostic importance of this histological feature.
Benign osteoklast benzeri multinükleer dev hücrelerin, kemik ve yumuşak doku tümörleri dışındaki tümörlere eşlik etmesi nadir bir histopatolojik bulgudur. Skuamöz hücreli karsinomlarda ise çok daha nadiren saptanmaktadır. Bir yıl önce hipofarengeal skuamöz hücreli karsinom nedeniyle opere olan 52 yaşındaki kadın hastada, nazofarinkste saptanan tümöre biyopsi yapıldı. Histopatolojik olarak skuamoid diferansiasyon gösteren atipik epitelyal hücrelerin oluşturduğu tümöral infiltrasyonun yanı sıra tümör dokusunu infiltre eden, geniş eozinofilik sitoplazmalı ve ortalama 10-20 nükleus içeren dev hücreler dikkati çekti. Dev hücrelerde atipi ve mitoz izlenmedi. İmmünhistokimyasal olarak tümör hücrelerinde pankeratin ve EMA ile dev hücrelerde ise LCA, CD68 ve Mac 387 ile reaksiyon gözlendi. Olguya, multinükleer dev hücrelerin eşlik ettiği orta derecede diferansiye skuamöz hücreli karsinom tanısı verildi. Olgumuzda tümörü infiltre eden dev hücrelerin benign karakterde ve monositik/histiyositik kökenli olduğu saptandı. Geniş olgu serilerinde yapılacak çalışmalar, bu histolojik özelliğin klinik ve prognostik önemine yönelik güvenilir bilgiler sağlayacaktır.
Nazofarenks, osteoklast benzeri dev hücre, skuamöz hücreli karsinom
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Yazar: Nilüfer Onak KANDEMİR
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Yazar: Sibel BEKTAŞ
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Yazar: Gamze YURDAKAN
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Yazar: Ebru TAŞ
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Bibtex @ { iuonkder12156, journal = {Türk Onkoloji Dergisi}, issn = {1300-7467}, address = {İstanbul Üniversitesi}, year = {2014}, volume = {24}, pages = {80 - 84}, doi = {}, title = {Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature}, key = {cite}, author = {BEKTAŞ, Sibel and KANDEMİR, Nilüfer Onak and YURDAKAN, Gamze and TAŞ, Ebru} }
APA KANDEMİR, N , BEKTAŞ, S , YURDAKAN, G , TAŞ, E . (2014). Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature. Türk Onkoloji Dergisi, 24 (2), 80-84. Retrieved from http://dergipark.gov.tr/iuonkder/issue/1074/12156
MLA KANDEMİR, N , BEKTAŞ, S , YURDAKAN, G , TAŞ, E . "Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature". Türk Onkoloji Dergisi 24 (2014): 80-84 <http://dergipark.gov.tr/iuonkder/issue/1074/12156>
Chicago KANDEMİR, N , BEKTAŞ, S , YURDAKAN, G , TAŞ, E . "Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature". Türk Onkoloji Dergisi 24 (2014): 80-84
RIS TY - JOUR T1 - Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature AU - Nilüfer Onak KANDEMİR , Sibel BEKTAŞ , Gamze YURDAKAN , Ebru TAŞ Y1 - 2014 PY - 2014 N1 - DO - T2 - Türk Onkoloji Dergisi JF - Journal JO - JOR SP - 80 EP - 84 VL - 24 IS - 2 SN - 1300-7467- M3 - UR - Y2 - 2018 ER -
EndNote %0 Türk Onkoloji Dergisi Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature %A Nilüfer Onak KANDEMİR , Sibel BEKTAŞ , Gamze YURDAKAN , Ebru TAŞ %T Pharyngeal squamous cell carcinoma with osteoclast-like giant cells: A case report and review of the literature %D 2014 %J Türk Onkoloji Dergisi %P 1300-7467- %V 24 %N 2 %R %U