Yıl 2014, Cilt , Sayı 2, Sayfalar 32 - 38 2014-07-01

The Effects of Nonylphenol on Gamete Physiology in Bovine

Selcen Süheyla ERGÜN [1] , Burcu ÜSTÜNER [2] , Selim ALÇAY [3] , Hakan SAĞIRKAYA [4] , Cevdet UĞUZ [5]

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Alkylphenol ethoxylates (APEOs) are used as non-ionic surfactants in variety of industrial, agricultiral and domestic products such as pesticides, detergents, paints and cosmetics. Therefore, these compounds can reach to humanbeing through foodchains. These endocrine disurpters also called Xenoestogen have estrogenic, carsinogenic and toxic effects. Nonylphenol (NP) exerts its estrogenic effects by binding to estrogen receptors. NP causes morphological and functional alterations in male and female genital tract and mammary glands. These alterations may induce infertility, mammary and prostate cancer. Therefore, the main purpose of this study is to determine the adverse effects of NP on sperm and oocytes. The effects environmentally relevant NP concentrations such as 0.01, 0.1, 1, 10 and 100 µg NP/ml were employed. NP mediated abnormalities in sperm DNA and oocyte maturation were inviestigated. Tunel assay was performed to determine the adverse effects of NP on sperm DNA, whereas the effects of NP on oocyte maturation in TCM-199 were tested. The present study demonstrated that 100 µg NP/ml concentration induced apoptosis by causing DNA breaks in bovine sperm cells. This study also showed that 100 µg NP/ml concentrations inhibits oocyte maturation. It is concluded that NP have adverse effects on the integrity of sperm DNA and oocyte maturation
Nonylphenol, sperm, oocyte, Tunel Assay, endocrine distruptors
Konular
Diğer ID JA39ZZ52AG
Dergi Bölümü Araştırma Makalesi
Yazarlar

Yazar: Selcen Süheyla ERGÜN

Yazar: Burcu ÜSTÜNER

Yazar: Selim ALÇAY

Yazar: Hakan SAĞIRKAYA

Yazar: Cevdet UĞUZ

Bibtex @ { jabs387531, journal = {Journal of Applied Biological Sciences}, issn = {}, eissn = {2146-0108}, address = {Nobel Bilim ve Araştırma Merkezi Limited}, year = {2014}, volume = {}, pages = {32 - 38}, doi = {}, title = {The Effects of Nonylphenol on Gamete Physiology in Bovine}, key = {cite}, author = {ALÇAY, Selim and ERGÜN, Selcen Süheyla and SAĞIRKAYA, Hakan and UĞUZ, Cevdet and ÜSTÜNER, Burcu} }
APA ERGÜN, S , ÜSTÜNER, B , ALÇAY, S , SAĞIRKAYA, H , UĞUZ, C . (2014). The Effects of Nonylphenol on Gamete Physiology in Bovine. Journal of Applied Biological Sciences, (2), 32-38. Retrieved from http://dergipark.gov.tr/jabs/issue/34935/387531
MLA ERGÜN, S , ÜSTÜNER, B , ALÇAY, S , SAĞIRKAYA, H , UĞUZ, C . "The Effects of Nonylphenol on Gamete Physiology in Bovine". Journal of Applied Biological Sciences (2014): 32-38 <http://dergipark.gov.tr/jabs/issue/34935/387531>
Chicago ERGÜN, S , ÜSTÜNER, B , ALÇAY, S , SAĞIRKAYA, H , UĞUZ, C . "The Effects of Nonylphenol on Gamete Physiology in Bovine". Journal of Applied Biological Sciences (2014): 32-38
RIS TY - JOUR T1 - The Effects of Nonylphenol on Gamete Physiology in Bovine AU - Selcen Süheyla ERGÜN , Burcu ÜSTÜNER , Selim ALÇAY , Hakan SAĞIRKAYA , Cevdet UĞUZ Y1 - 2014 PY - 2014 N1 - DO - T2 - Journal of Applied Biological Sciences JF - Journal JO - JOR SP - 32 EP - 38 VL - IS - 2 SN - -2146-0108 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Applied Biological Sciences The Effects of Nonylphenol on Gamete Physiology in Bovine %A Selcen Süheyla ERGÜN , Burcu ÜSTÜNER , Selim ALÇAY , Hakan SAĞIRKAYA , Cevdet UĞUZ %T The Effects of Nonylphenol on Gamete Physiology in Bovine %D 2014 %J Journal of Applied Biological Sciences %P -2146-0108 %V %N 2 %R %U
ISNAD ERGÜN, Selcen Süheyla , ÜSTÜNER, Burcu , ALÇAY, Selim , SAĞIRKAYA, Hakan , UĞUZ, Cevdet . "The Effects of Nonylphenol on Gamete Physiology in Bovine". Journal of Applied Biological Sciences / 2 (Temmuz 2014): 32-38.