Year 2018, Volume 1, Issue 3, Pages 28 - 28 2018-12-08

Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts

Zbigniev BALION [1] , Aistė JEKABSONE [2] , Kristina RAMANAUSKIENE [3] , Daiva MAJIENĖ [4]

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Glioblastomas are characterized by the highest degree of invasion and the worst survival prediction because of the lack of efficient therapy that would not be harmful for sensitive and vitally-important surrounding brain tissue. Propolis is a multicomponent substance known for numerous biological effects including antioxidant-related stimulation of immune system and tissue regeneration as well as anticancer activity. The aim of this study was to investigate the effects on viability of glioblastoma (C6 rat glioma cell line) and healthy brain cells (primary cerebellar granule cells) of aqueous (AqEP), polyethylene glycol-aqueous (Pg-AqEP) and ethanolic (EEP) propolis extracts. After 24h treatment, all the extracts tested decreased C6 cell viability in a concentration-dependent manner. Statistically significant increase in the number of dead cells was achieved at the following concentrations of phenolic compounds: 15-18 µg/ml for AqEP, 10 µg/ml for Pg-AqEP and 5 - 7 µg/ml EEP. We have also tested how same propolis extracts influence viability of primary cerebellar granule cell cultures comprised of 76±3 % neurons, 16±2 % astrocytes and 8±2% microglia and found no decrease in cell viability after 24h treatment.

In conclusion, propolis extracts exert selective cytotoxicity against C6 cells while preserving healthy brain cells and could be recommended as adjuvant of glioblastoma therapy as well as safe food supplements for cancer prevention.

Propolis, Aqueous extract, Anticancer Properties
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Primary Language en
Subjects
Journal Section 2nd Propolis Conference Special Issue
Authors

Author: Zbigniev BALION (Primary Author)

Author: Aistė JEKABSONE

Author: Kristina RAMANAUSKIENE

Author: Daiva MAJIENĖ

Bibtex @conference paper { jan488713, journal = {Journal of Apitherapy and Nature}, issn = {}, eissn = {2667-4734}, address = {Oktay YILDIZ}, year = {2018}, volume = {1}, pages = {28 - 28}, doi = {}, title = {Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts}, key = {cite}, author = {BALION, Zbigniev and JEKABSONE, Aistė and RAMANAUSKIENE, Kristina and MAJIENĖ, Daiva} }
APA BALION, Z , JEKABSONE, A , RAMANAUSKIENE, K , MAJIENĖ, D . (2018). Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts. Journal of Apitherapy and Nature, 1 (3), 28-28. Retrieved from http://dergipark.gov.tr/jan/issue/40577/488713
MLA BALION, Z , JEKABSONE, A , RAMANAUSKIENE, K , MAJIENĖ, D . "Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts". Journal of Apitherapy and Nature 1 (2018): 28-28 <http://dergipark.gov.tr/jan/issue/40577/488713>
Chicago BALION, Z , JEKABSONE, A , RAMANAUSKIENE, K , MAJIENĖ, D . "Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts". Journal of Apitherapy and Nature 1 (2018): 28-28
RIS TY - JOUR T1 - Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts AU - Zbigniev BALION , Aistė JEKABSONE , Kristina RAMANAUSKIENE , Daiva MAJIENĖ Y1 - 2018 PY - 2018 N1 - DO - T2 - Journal of Apitherapy and Nature JF - Journal JO - JOR SP - 28 EP - 28 VL - 1 IS - 3 SN - -2667-4734 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Apitherapy and Nature Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts %A Zbigniev BALION , Aistė JEKABSONE , Kristina RAMANAUSKIENE , Daiva MAJIENĖ %T Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts %D 2018 %J Journal of Apitherapy and Nature %P -2667-4734 %V 1 %N 3 %R %U
ISNAD BALION, Zbigniev , JEKABSONE, Aistė , RAMANAUSKIENE, Kristina , MAJIENĖ, Daiva . "Anticancer Properties of Aqueous and Nonaqueous Propolis Extracts". Journal of Apitherapy and Nature 1 / 3 (December 2018): 28-28.