Yıl 2019, Cilt 3, Sayı 1, Sayfalar 49 - 53 2019-01-27

Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging
Preoperatif 3T manyetik rezonans görüntülemede tümör çevresi, pektoral kas önü ve yaygın ödemin meme kanserinin histopatolojik bulguları ile ilişkisi

Ayşegül Akdoğan Gemici [1] , Safiye Tokgoz Ozal [2] , Elif Hocaoğlu [3] , Gözde Arslan [4] , Ebru Sen [5] , Serdar Altınay [6] , Ercan İnci [7]

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Aim: Preoperative breast magnetic resonance imaging (MRI) findings can provide rich information about the prognosis of the disease. Morphologic and dynamic features are especially used for it. We aimed to compare peritumoral, prepectoral, and diffuse edema identified in MRI with histopathologic findings, and to show how prognostic information can be gathered from the identification of edema.

Methods: We conducted a retrospective cohort study with forty-six women who underwent breast DCE-MRI as part of the pre-surgical evaluation between January and August 2018 were included in the study. Signal enhancements similar to water that were localized to the prepectoral or peritumoral areas or diffuse enhancements on T2A-weighted sequences were considered as edema. The presence of edema was compared with clinicopathologic parameters such as cancer type, tumor size, histologic grade, ER-PR receptor positivity, Her2 positivity, Ki-67 labelling index and lymphovascular invasion.

Results: The mean age of the participants was 53.15±11.75 (range, 27-80) years. Eleven patients had diffuse edema, 27 patients had peritumoral edema, and 5 patients had prepectoral edema. Nineteen luminal A cancers, 17 luminal B, 9 triple-negative, and 1 Her2 cancer were seen. Peritumoral edema was associated with lymphovascular invasion positivity (p=0.002). Tumor size and the level of Ki-67 was associated with peritumoral edema (p=0.001, p=0.009). The odds of observing prepectoral edema showed no statistically significant difference in the presence of lymphovascular invasion positivity and other parameters. The presence of diffuse edema showed significant differences depending on tumor size measurements (p=0.026).

Conclusion: Edema in breast MRI can provide information about histopathologic findings, particularly about lymphovascular invasion. The authors suggest that different edema types could be mentioned in radiology reports as a matter of routine given that such findings can provide information about the prognosis.

Amaç: Preoperatif meme manyetik rezonans görüntüleme (MRG), meme kanserinin prognozu konusunda zengin bilgiler sağlar. Bunun için özellikle morfolojik ve dinamik özellikler kullanılır. Çalışmamızda meme MRG’de peritümöral, prepektoral, diffüz ödemin meme kanserinin histopatolojik prognostic parametreler ile ilişkisin araştırmayı ve meme MRG’den prognoz ile ilgili edinilen bilgileri değerlendirmeyi amaçladık.

Yöntemler: Ocak-Ağustos 2018 tarihleri arasında hastanemizde meme kanseri tanısı almış ve ameliyat öncesi değerlendirmede kontrastlı dinamik meme MRG çekilen 46 hasta çalışmaya dahil edildi. T2A sekansta tümör çevresinde, pektoral kas önünde ya da tüm memede izlenen su ile benzer sinyal ödem lehine değerlendirildi. Her bir ödem tipi; kanser tipi, tümör boyutu, histolojik evre, ER-PR reseptör pozitifliği, Her2 reseptör pozitifliği, Ki67 proliferasyon indeksi ve lenfovasküler invazyon gibi klinikopatolojik parametreler ile değerlendirildi.

Bulgular: Ortalama yaş 53.15±11.75 (aralık 27-80) idi. Meme MRG’de 11 hastada diffüz, 27 hastada peritümöral, 5 hastada prepektoral ödem bulgusu izlenmekteydi. 19 lüminal A, 17 lüminal B, 9 üçlü negatif, 1 Her2 kanser mevcuttu.Peritümöral ödem LVI pozitifliği ile ilişkili bulundu (p=0.002). Tümör boyutu ve Ki-67 indexi peritümöral ödemle ilişkilidir (p=0.001, p=0.009).Prepektoral ödem ile değerlendirilen parametreler arasında ilişkili görülmedi. Diffüz ödem tümör boyutuna göre farklılık gösterir (p=0.026).

Sonuç: Meme MRG’de görülen peritümöral ödem LVI pozitifliği açısından bilgi vericidir. Farklı ödem tipleri prognoz açısından bilgiler taşıdığından rutin raporlamalarda belirtilmelidir.

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Orcid: 0000-0002-7707-1849
Yazar: Ayşegül Akdoğan Gemici (Sorumlu Yazar)
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of Radiology, ISTANBUL.
Ülke: Turkey


Orcid: 0000-0003-1690-4744
Yazar: Safiye Tokgoz Ozal
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of Radiology, ISTANBUL
Ülke: Turkey


Orcid: 0000-0002-2506-4794
Yazar: Elif Hocaoğlu
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of Radiology, ISTANBUL.
Ülke: Turkey


Orcid: 0000-0003-0991-1380
Yazar: Gözde Arslan
Kurum: Maltepe University, Department of Radiology, ISTANBUL.
Ülke: Turkey


Orcid: 0000-0002-0121-4540
Yazar: Ebru Sen
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of General Surgery, ISTANBUL.
Ülke: Turkey


Orcid: 0000-0003-0267-8360
Yazar: Serdar Altınay
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of Pathology, ISTANBUL.
Ülke: Turkey


Orcid: 0000-0002-3791-2471
Yazar: Ercan İnci
Kurum: Health Science University, Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Department of Radiology, ISTANBUL.
Ülke: Turkey


Bibtex @araştırma makalesi { josam512779, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih Başak}, year = {2019}, volume = {3}, pages = {49 - 53}, doi = {10.28982/josam.512779}, title = {Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging}, key = {cite}, author = {Akdoğan Gemici, Ayşegül and Tokgoz Ozal, Safiye and Hocaoğlu, Elif and Arslan, Gözde and Sen, Ebru and Altınay, Serdar and İnci, Ercan} }
APA Akdoğan Gemici, A , Tokgoz Ozal, S , Hocaoğlu, E , Arslan, G , Sen, E , Altınay, S , İnci, E . (2019). Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging. Journal of Surgery and Medicine, 3 (1), 49-53. DOI: 10.28982/josam.512779
MLA Akdoğan Gemici, A , Tokgoz Ozal, S , Hocaoğlu, E , Arslan, G , Sen, E , Altınay, S , İnci, E . "Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging". Journal of Surgery and Medicine 3 (2019): 49-53 <http://dergipark.gov.tr/josam/issue/42845/512779>
Chicago Akdoğan Gemici, A , Tokgoz Ozal, S , Hocaoğlu, E , Arslan, G , Sen, E , Altınay, S , İnci, E . "Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging". Journal of Surgery and Medicine 3 (2019): 49-53
RIS TY - JOUR T1 - Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging AU - Ayşegül Akdoğan Gemici , Safiye Tokgoz Ozal , Elif Hocaoğlu , Gözde Arslan , Ebru Sen , Serdar Altınay , Ercan İnci Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.512779 DO - 10.28982/josam.512779 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 49 EP - 53 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.512779 UR - http://dx.doi.org/10.28982/josam.512779 Y2 - 2019 ER -
EndNote %0 Journal of Surgery and Medicine Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging %A Ayşegül Akdoğan Gemici , Safiye Tokgoz Ozal , Elif Hocaoğlu , Gözde Arslan , Ebru Sen , Serdar Altınay , Ercan İnci %T Relation of peritumoral, prepectoral and diffuse edema with histopathologic findings of breast cancer in preoperative 3T magnetic resonance imaging %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.512779 %U 10.28982/josam.512779
ISNAD Akdoğan Gemici, Ayşegül , Tokgoz Ozal, Safiye , Hocaoğlu, Elif , Arslan, Gözde , Sen, Ebru , Altınay, Serdar , İnci, Ercan . "Preoperatif 3T manyetik rezonans görüntülemede tümör çevresi, pektoral kas önü ve yaygın ödemin meme kanserinin histopatolojik bulguları ile ilişkisi". Journal of Surgery and Medicine 3 / 1 (Ocak 2019): 49-53. http://dx.doi.org/10.28982/josam.512779