Yıl 2019, Cilt 6, Sayı 1, Sayfalar 1 - 14 2019-05-01

Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Şebnem Şenol [1] , Emel Akyol [2]

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The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651),  1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959)  were used as photo-initiators in the synthesis of hydrogels and  hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels.  Swelling and drug release studies have been performed under different pH conditions.


Hydrogels, Photopolymerization, Donepezil HCl, Polyethylene diacyrlate, Alzheimer's Disease
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Birincil Dil en
Konular Kimya, Uygulamalı
Yayımlanma Tarihi Winter
Dergi Bölümü Makaleler
Yazarlar

Yazar: Şebnem Şenol
Kurum: Yıldız Teknik Üniversitesi, Kimya Mühendisliği Bölümü
Ülke: Turkey


Yazar: Emel Akyol (Sorumlu Yazar)
Kurum: Yıldız Teknik Üniversitesi, Kimya Mühendisliği Bölümü
Ülke: Turkey


Bibtex @araştırma makalesi { jotcsa485817, journal = {Journal of the Turkish Chemical Society, Section A: Chemistry}, issn = {}, eissn = {2149-0120}, address = {Türkiye Kimya Derneği}, year = {2019}, volume = {6}, pages = {1 - 14}, doi = {10.18596/jotcsa.485817}, title = {Study on the preparation and drug release property of Modified PEG-DA based hydrogels}, key = {cite}, author = {Şenol, Şebnem and Akyol, Emel} }
APA Şenol, Ş , Akyol, E . (2019). Study on the preparation and drug release property of Modified PEG-DA based hydrogels. Journal of the Turkish Chemical Society, Section A: Chemistry, 6 (1), 1-14. DOI: 10.18596/jotcsa.485817
MLA Şenol, Ş , Akyol, E . "Study on the preparation and drug release property of Modified PEG-DA based hydrogels". Journal of the Turkish Chemical Society, Section A: Chemistry 6 (2019): 1-14 <http://dergipark.gov.tr/jotcsa/issue/42264/485817>
Chicago Şenol, Ş , Akyol, E . "Study on the preparation and drug release property of Modified PEG-DA based hydrogels". Journal of the Turkish Chemical Society, Section A: Chemistry 6 (2019): 1-14
RIS TY - JOUR T1 - Study on the preparation and drug release property of Modified PEG-DA based hydrogels AU - Şebnem Şenol , Emel Akyol Y1 - 2019 PY - 2019 N1 - doi: 10.18596/jotcsa.485817 DO - 10.18596/jotcsa.485817 T2 - Journal of the Turkish Chemical Society, Section A: Chemistry JF - Journal JO - JOR SP - 1 EP - 14 VL - 6 IS - 1 SN - -2149-0120 M3 - doi: 10.18596/jotcsa.485817 UR - http://dx.doi.org/10.18596/jotcsa.485817 Y2 - 2019 ER -
EndNote %0 Journal of the Turkish Chemical Society, Section A: Chemistry Study on the preparation and drug release property of Modified PEG-DA based hydrogels %A Şebnem Şenol , Emel Akyol %T Study on the preparation and drug release property of Modified PEG-DA based hydrogels %D 2019 %J Journal of the Turkish Chemical Society, Section A: Chemistry %P -2149-0120 %V 6 %N 1 %R doi: 10.18596/jotcsa.485817 %U 10.18596/jotcsa.485817
ISNAD Şenol, Şebnem , Akyol, Emel . "Study on the preparation and drug release property of Modified PEG-DA based hydrogels". Journal of the Turkish Chemical Society, Section A: Chemistry 6 / 1 (Mayıs 2019): 1-14. http://dx.doi.org/10.18596/jotcsa.485817