Yıl 2018, Cilt 19, Sayı 3, Sayfalar 86 - 92 2018-07-23

EVALUATION OF COGNITIVE IMPAIRMENT IN RHEUMATOID ARTHRITIS: PREDICTIVE VALUE OF JOINT DESTRUCTION AND DISEASE ACTIVITY
ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ

Derya GÜZEL [1] , Sinem SAĞ [2] , Mustafa Serdar SAĞ [3] , İbrahim TEKEOĞLU [4] , Ayhan KAMANLI [5] , Kemal NAS [6]

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OBJECTIVE: Rheumatoid Arthritis (RA) cause poor cognitive functions including reduced memory, orientation and attention. The aim of the present study is to evaluate joint destruction and other parameters of disease as a predictor of cognitive functions in RA.

MATERIAL AND METHODS: This cross-sectional study included forty five patients and forty healthy controls. Radiological progression score (≥0.5 the modified Sharp/ van der Heijde scores- MTSs), disease activity score of 28 joints (DAS-28) and disease activity score of 44 joints (DAS-44) were evaluated in patients with RA. Mini Mental State Examination (MMSE) and Hospital Anxiety Depression Scale (HADS) were evaluated and the results were compared between patients and control groups to determinate cognitive functions.

RESULTS: There was a statistically significant difference between groups in terms of MMSE scores (p=0.003). There were no significant differences in terms of anxiety and depression levels between RA and control groups. MMSE score was correlated with disease duration (p=0.011, r=- 0.371), Sharp score (p=0.018, r=-0.350) and DAS-28 score (p=0.044, r=-0.296). Depression score was also correlated with DAS (p=0.004, r=0.425). No relationship was found between Rheumatoid factor levels, anti-cyclic citrullinated peptide levels and the cognitive function tests.

CONCLUSIONS: The results indicate that exposure to inflammatory mediators in patients with long standing RA may lead to deterioration on central nervous system as long as affecting joints. Cognitive deterioration was correlated with disease severity and joint destruction. Thus, the radiographic joint destruction can be a positive predictor of reflecting the extent of neuronal damage and cognitive deterioration during this chronic process in RA.

AMAÇ: Romatoid Artrit (RA), oryantasyon, dikkat ve bellek zayıflığı gibi azalmış bilişsel işlevlere neden olur. Sunulan bu çalışmanın amacı RA’da bilişsel işlevlerin bir belirleyicisi olarak eklem yıkımını ve hastalığın diğer parametrelerini değerlendirmektir.

GEREÇ VE YÖNTEM: Bu kesitsel çalışma, 45 hasta ve 40 sağlıklı kontrol içemektedir. RA’lı hastalarda radyolojik progresyon skoru (≥0.5, modifiye Sharp / van der Heijde skorları- MTS’ler), 28 eklemin hastalık aktivite skoru (DAS-28) ve 44 eklemin hastalık aktivite skoru (DAS-44) değerlendirildi. Mini Mental Test (MMSE) ve Hastane Anksiyete Depresyon Ölçeği (HADÖ) değerlendirildi. Sonuçlar, bilişsel işlevleri belirlemek için hasta ve kontrol grubu arasında karşılaştırıldı.

BULGULAR: MMSE skorları açısından gruplar arasında istatistiksel olarak anlamlı fark vardı (p=0.003). RA ve kontrol grupları arasında anksiyete ve depresyon düzeyleri açısından anlamlı farklılık yoktu. MMSE skoru; hastalık süresi (p=0.011, r=-0.371), Sharp skoru (p=0.018, r=-0.350) ve DAS-28(p=0.044, r=-0.296) skoru ile ilişkilendirildi. Depresyon skoru da DAS ile ilişkiliydi (p=0.004, r=0.425). Romatoid faktör düzeyleri, antisiklik sitrullinat peptid düzeyleri ve bilişsel işlev testleri arasında herhangi bir ilişki bulunamadı.

SONUÇ: Sonuçlar, uzun süredir RA olan hastalarda inflamatuar mediatörlere maruz kalmanın, eklemleri etkilediği sürece merkezi sinir sisteminde de bozulmaya neden olabileceğini göstermektedir. Bilişsel bozulma, hastalık şiddeti ve eklem yıkımı ile ilişkili idi. Dolayısıyla, radyografik eklem hasarı, RA’daki bu kronik süreç boyunca nöronal hasarın ve bilişsel bozulmanın boyutunu yansıtan pozitif bir ön belirteç olabilir.

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Birincil Dil tr
Konular
Dergi Bölümü Makaleler-Araştırma Yazıları
Yazarlar

Yazar: Derya GÜZEL (Sorumlu Yazar)

Yazar: Sinem SAĞ

Yazar: Mustafa Serdar SAĞ

Yazar: İbrahim TEKEOĞLU

Yazar: Ayhan KAMANLI

Yazar: Kemal NAS

Bibtex @araştırma makalesi { kocatepetip446832, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {Afyon Kocatepe Üniversitesi}, year = {2018}, volume = {19}, pages = {86 - 92}, doi = {10.18229/kocatepetip.446832}, title = {ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ}, key = {cite}, author = {TEKEOĞLU, İbrahim and SAĞ, Sinem and SAĞ, Mustafa Serdar and NAS, Kemal and GÜZEL, Derya and KAMANLI, Ayhan} }
APA GÜZEL, D , SAĞ, S , SAĞ, M , TEKEOĞLU, İ , KAMANLI, A , NAS, K . (2018). ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ. Kocatepe Tıp Dergisi, 19 (3), 86-92. DOI: 10.18229/kocatepetip.446832
MLA GÜZEL, D , SAĞ, S , SAĞ, M , TEKEOĞLU, İ , KAMANLI, A , NAS, K . "ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ". Kocatepe Tıp Dergisi 19 (2018): 86-92 <http://dergipark.gov.tr/kocatepetip/issue/38516/446832>
Chicago GÜZEL, D , SAĞ, S , SAĞ, M , TEKEOĞLU, İ , KAMANLI, A , NAS, K . "ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ". Kocatepe Tıp Dergisi 19 (2018): 86-92
RIS TY - JOUR T1 - ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ AU - Derya GÜZEL , Sinem SAĞ , Mustafa Serdar SAĞ , İbrahim TEKEOĞLU , Ayhan KAMANLI , Kemal NAS Y1 - 2018 PY - 2018 N1 - doi: 10.18229/kocatepetip.446832 DO - 10.18229/kocatepetip.446832 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 86 EP - 92 VL - 19 IS - 3 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.446832 UR - http://dx.doi.org/10.18229/kocatepetip.446832 Y2 - 2018 ER -
EndNote %0 Kocatepe Tıp Dergisi ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ %A Derya GÜZEL , Sinem SAĞ , Mustafa Serdar SAĞ , İbrahim TEKEOĞLU , Ayhan KAMANLI , Kemal NAS %T ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ %D 2018 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 19 %N 3 %R doi: 10.18229/kocatepetip.446832 %U 10.18229/kocatepetip.446832
ISNAD GÜZEL, Derya , SAĞ, Sinem , SAĞ, Mustafa Serdar , TEKEOĞLU, İbrahim , KAMANLI, Ayhan , NAS, Kemal . "ROMATOİD ARTRİTTE BİLİŞSEL BOZUKLUĞUN DEĞERLENDİRİLMESİ: EKLEM YIKIMI VE HASTALIK AKTİVİTESİNİN BELİRLEYİCİ DEĞERİ". Kocatepe Tıp Dergisi 19 / 3 (Temmuz 2018): 86-92. http://dx.doi.org/10.18229/kocatepetip.446832