Yıl 2017, Cilt 9, Sayı 3, Sayfalar 196 - 201 2017-09-22

The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication

Mücahit Günaydın [1] , Süha Türkmen [2] , Yunus Karaca [3] , Özgür Tatlı [4] , Furkan Yıldırım [5] , Buket Akcan Altınkaynak [6] , Abdulkadir Gündüz [7]

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Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication.

Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients’ PC levels at time of admission and after treatment were compared with those of a control group.

Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p =0.305, patient group 0.025 ± 0.01, control group 0.026 ± 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p = 0.006, admission 0.025 ± 0.01, post-treatment 0.017 ± 0.008). No significant correlation was determined between patients’ carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient = -0.006, p= 0.971).

Conclusion: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication.

Carbon monoxide poisoning, Oxidative stress, Protein carbonyl
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Konular Sağlık Bilimleri ve Hizmetleri
Dergi Bölümü Makaleler
Yazarlar

Yazar: Mücahit Günaydın
Kurum: Giresun University, Faculty of Medicine, Department of Emergency Medicine
Ülke: Turkey


Yazar: Süha Türkmen

Yazar: Yunus Karaca

Yazar: Özgür Tatlı

Yazar: Furkan Yıldırım

Yazar: Buket Akcan Altınkaynak

Yazar: Abdulkadir Gündüz

Bibtex @araştırma makalesi { ktd331426, journal = {Konuralp Tıp Dergisi}, issn = {1309-3878}, eissn = {1309-3878}, address = {Düzce Üniversitesi}, year = {2017}, volume = {9}, pages = {196 - 201}, doi = {10.18521/ktd.331426}, title = {The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication}, key = {cite}, author = {Tatlı, Özgür and Karaca, Yunus and Türkmen, Süha and Günaydın, Mücahit and Yıldırım, Furkan and Akcan Altınkaynak, Buket and Gündüz, Abdulkadir} }
APA Günaydın, M , Türkmen, S , Karaca, Y , Tatlı, Ö , Yıldırım, F , Akcan Altınkaynak, B , Gündüz, A . (2017). The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication. Konuralp Tıp Dergisi, 9 (3), 196-201. DOI: 10.18521/ktd.331426
MLA Günaydın, M , Türkmen, S , Karaca, Y , Tatlı, Ö , Yıldırım, F , Akcan Altınkaynak, B , Gündüz, A . "The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication". Konuralp Tıp Dergisi 9 (2017): 196-201 <http://dergipark.gov.tr/ktd/issue/32172/331426>
Chicago Günaydın, M , Türkmen, S , Karaca, Y , Tatlı, Ö , Yıldırım, F , Akcan Altınkaynak, B , Gündüz, A . "The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication". Konuralp Tıp Dergisi 9 (2017): 196-201
RIS TY - JOUR T1 - The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication AU - Mücahit Günaydın , Süha Türkmen , Yunus Karaca , Özgür Tatlı , Furkan Yıldırım , Buket Akcan Altınkaynak , Abdulkadir Gündüz Y1 - 2017 PY - 2017 N1 - doi: 10.18521/ktd.331426 DO - 10.18521/ktd.331426 T2 - Konuralp Tıp Dergisi JF - Journal JO - JOR SP - 196 EP - 201 VL - 9 IS - 3 SN - 1309-3878-1309-3878 M3 - doi: 10.18521/ktd.331426 UR - http://dx.doi.org/10.18521/ktd.331426 Y2 - 2017 ER -
EndNote %0 Konuralp Tıp Dergisi The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication %A Mücahit Günaydın , Süha Türkmen , Yunus Karaca , Özgür Tatlı , Furkan Yıldırım , Buket Akcan Altınkaynak , Abdulkadir Gündüz %T The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication %D 2017 %J Konuralp Tıp Dergisi %P 1309-3878-1309-3878 %V 9 %N 3 %R doi: 10.18521/ktd.331426 %U 10.18521/ktd.331426
ISNAD Günaydın, Mücahit , Türkmen, Süha , Karaca, Yunus , Tatlı, Özgür , Yıldırım, Furkan , Akcan Altınkaynak, Buket , Gündüz, Abdulkadir . "The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication". Konuralp Tıp Dergisi 9 / 3 (Eylül 2017): 196-201. http://dx.doi.org/10.18521/ktd.331426