Yıl 2018, Cilt 11, Sayı 3, Sayfalar 232 - 237 2018-09-01

Saha Koşullarında Enfeksiyöz Bovine Keratokonjuktivitis’in Sağaltımı: Subkonjuktival Oksitetrasiklin Enjeksiyonuna Karşı İntrapalpebral Enjeksiyon
The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline

Göksen ÇEÇEN [1] , İbrahim AKIN [2] , Ayşe Ebru BORUM [3]

54 96

Bu çalışmanın amacı, infeksiyöz bovine keratokonjuktivitis (IBK)’in sağaltımında, göze intrapalpebral (IPa) enjeksiyon ile uygulanılan oksitetrasiklin’in, subkonjuktival (SCo) enjeksiyon ile karşılaştırıldığındaki etkinliğini belirlemekti. Çalışmada, IBK’nın şiddetli klinik bulguları bulunan 2-4 yaşındaki, dişi, 15 Holstein Friesian sığıra ait 20 göz değerlendirildi. Etkilenen hayvanlar unilateral (n=10; % 66,7) ve bilateral (n=5; % 33,3) semptomlara sahipti. 0. günde tüm oküler swab örneklerinden Morexella bovis izole edildi ve oksitetrasikline duyarlı idi (% 100). 0, 3 ve 6. günlerde günde bir kez toplam 200 mg dozda oksitetrasiklin (100 mg/ml) IPa (n=10) ve SCo (n=10) olarak enjekte edildi. Enjeksiyonlardan sonra, korneal ülser iyileşmesi şekilleninceye kadar haftalık olarak IBK ile ilişkili lezyonlar yönünden hayvanlar tekrar muayene edildi. Mikrobiyolojik muayene birer hafta ara ile 3 kez tekrarlandı. Lezyonun iyileşme zamanı üzerine enjeksiyon tipinin etkisi yoktu. Lezyonun büyüklüğü ve bulunduğu tarafın iyileşme zamanı üzerine belirgin etkisi vardı (p<0.001). Küçük lezyonlar mikrobiyolojik değerlendirmede daha erken dönemde temiz bulundu. Lezyon büyüklüğü mikrobiyal gelişimi belirgin olarak etkiledi (p<0.001). Sonuç olarak, her iki uygulama ile aynı terapötik etki sağlandı. Bununla birlikte, bu çalışmada saha koşullarında özellikle ağrılı gözlerde IPa enjeksiyon yolu ile verilen oksitetrasiklin, SCo enjeksiyondan nispeten daha kolay, daha rahat ve daha az invazivdi. İlave olarak, bu çalışmada kullanılan doz (0, 3 ve 6. günlerde günde bir kez 200 mg) IBK’lı sığırlar için yeterli idi.

The purpose of this study was to determine the efficacy of oxytetracycline when applied intrapalpebral (IPa) injection to the eye, compared with subconjunctival (SCo) injection, in the treatment of infectious bovine keratoconjunctivitis (IBK). Twenty eyes with severe clinical signs of IBK, of 15 Holstein Friesian female cattle aged 2–4 years were evaluated in this study. The affected animals had unilateral (n=10; 66.7%) and bilateral (n=5; 33.3%) symptoms. Moraxella bovis were identified in all ocular swabs samples on day 0 and all isolates were susceptible to oxytetracycline (100%).  Oxytetracycline (100 mg/ml) was injected IPa (n=10) and SCo (n=10) at a total dose of 200 mg once daily on days 0, 3 and 6. After injections, the animals were re-examined for resolution of lesions associated with IBK weekly until the corneal ulcer healed. Microbiologic examination was repeated 3 times at intervals of 1 week. There is no effect of injection type on healing time of the lesion. Size and side of the lesion have a significant effect on healing time (p<0.001). It was found that small lesions had earlier clean in terms of the microbiologic evaluation. Lesion size has a significant effect on microbial growth (p<0.001). In conclusion, the same therapeutic effect was achieved in both applications. However, oxytetracycline given by IPa injection was comparatively easy, more comfortable and less invasive especially for painful eyes against IBK than SCo injection under the conditions of this study. In addition, it was enough for cattle with IBK at the dosage (200 mg, once daily on days 0, 3 and 6) of used in the study.

  • Alexander D. Infectious bovine keratoconjunctivitis: A review of cases in clinical practice. Vet Clin North Am Food Anim Pract. 2010; 26: 487-503.
  • Angelos JA, Hess JF, George LW. Cloning and characterization of a Moraxella bovis cytotoxin gene. Am J Vet Res. 2001; 62: 1222-1228.
  • Bedford PGC. Ocular diseases. 917-926. In: Andrews AH, Blowey RW, Boyd H et al. (Eds.), Bovine Medicine. 2nd ed. London, 2004; Blackwell Scientific Publications.Angelos JA. Infectious Bovine Keratoconjunctivitis (Pinkeye). Vet Clin Food Anim. 2015; 31: 61–79.
  • Cullen JN, Yuan C, Totton S, Dzikamunhenga R, Coetze JF, da Silva N, Wang C, O’Connor AM A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update. Anim Health Res Rev. 2016; 17(1): 60-75.
  • Burns M, O’Connor A. Assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with Moraxella bovis vaccines in young cattle. Vaccine. 2008; 26(2): 144-152.
  • Zielinski GC, Piscitelli HG, Perez-Monti H, Stobbs LA, Zimmermann AG. Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). Vet Ther. 2002; 3(2): 196-205.
  • Brown MH, Brightman AH, Fenwick BW, Rider MA. Infectious Bovine Keratoconjunctivitis: A Review. J Vet Intern Med. 1998; 12: 259-266.
  • McConnel CS, Shum L, House JK. Infectious bovine keratoconjunctivitis antimicrobial therapy. Aust Vet J. 2007; 85(1-2), 65-69.
  • George LW, Wilson WD, Baggot JD, Mihalyi JE. Antibiotic treatment of Moraxella bovis infection in cattle. J Am Vet Med Assoc. 1984; 185(10): 1206-1209.
  • George LW, Smith JA, Kaswan R. Distribution of oxytetracycline into ocular tissues and tears of calves. J Vet Pharmacol Ther. 1985; 8(1): 47-54.
  • Senturk S, Cetin C, Temizel M, Ozel E. Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Vet Ophthalmol. 2007; 10(3): 186-189.
  • Quinn PJ, Cater ME, Markey BK, Carter CR. Clinical Veterinary Microbiology. London, Wolfe-Mosby. 1994; 284-286.
  • Gokce I, Citil M, Genc O, Kankavi O. A comparison of the efficacy of florfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Ir Vet J. 2002; 55(11): 573-576.
  • Pickett JP. Eye Disease. In: Howard JL, Smith RA (Eds.). Current Veterinary Therapy Food Animal Practice. 4th Ed, Saunders. 1999; 633-657.
  • Prieto C, Serra DO, Martina P, Jacobs M, Bosch AM, Yantorno OM. Evaluation of biofilm-forming capacity of Moraxella bovis, the primary causative agent of infectious bovine keratoconjunctivitis. Vet Microbiol. 2013; 166(3-4): 504-15.
  • Shryock TR, White DW, Werner CS. Antimicrobial susceptibility of Moraxella bovis. Vet Microbiol. 1998; 61: 305-309.
  • Zielinski G, Piscitelli H, Perez-Monti H, Stobbs LA. Antibiotic sensitivity of an Argentine strain collection of Moraxella bovis. Vet Ther. 2000; 1: 199-204..
Birincil Dil en
Konular Fen
Dergi Bölümü ARAŞTIRMA MAKALESİ
Yazarlar

Yazar: Göksen ÇEÇEN

Yazar: İbrahim AKIN

Yazar: Ayşe Ebru BORUM (Sorumlu Yazar)
Ülke: Turkey


Bibtex @araştırma makalesi { kvj408380, journal = {Kocatepe Veteriner Dergisi}, issn = {1308-1594}, eissn = {2147-6853}, address = {Afyon Kocatepe Üniversitesi}, year = {2018}, volume = {11}, pages = {232 - 237}, doi = {10.30607/kvj.408380}, title = {The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline}, key = {cite}, author = {AKIN, İbrahim and ÇEÇEN, Göksen and BORUM, Ayşe Ebru} }
APA ÇEÇEN, G , AKIN, İ , BORUM, A . (2018). The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. Kocatepe Veteriner Dergisi, 11 (3), 232-237. DOI: 10.30607/kvj.408380
MLA ÇEÇEN, G , AKIN, İ , BORUM, A . "The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline". Kocatepe Veteriner Dergisi 11 (2018): 232-237 <http://dergipark.gov.tr/kvj/issue/37070/408380>
Chicago ÇEÇEN, G , AKIN, İ , BORUM, A . "The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline". Kocatepe Veteriner Dergisi 11 (2018): 232-237
RIS TY - JOUR T1 - The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline AU - Göksen ÇEÇEN , İbrahim AKIN , Ayşe Ebru BORUM Y1 - 2018 PY - 2018 N1 - doi: 10.30607/kvj.408380 DO - 10.30607/kvj.408380 T2 - Kocatepe Veteriner Dergisi JF - Journal JO - JOR SP - 232 EP - 237 VL - 11 IS - 3 SN - 1308-1594-2147-6853 M3 - doi: 10.30607/kvj.408380 UR - http://dx.doi.org/10.30607/kvj.408380 Y2 - 2018 ER -
EndNote %0 Kocatepe Veteriner Dergisi The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline %A Göksen ÇEÇEN , İbrahim AKIN , Ayşe Ebru BORUM %T The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline %D 2018 %J Kocatepe Veteriner Dergisi %P 1308-1594-2147-6853 %V 11 %N 3 %R doi: 10.30607/kvj.408380 %U 10.30607/kvj.408380
ISNAD ÇEÇEN, Göksen , AKIN, İbrahim , BORUM, Ayşe Ebru . "Saha Koşullarında Enfeksiyöz Bovine Keratokonjuktivitis’in Sağaltımı: Subkonjuktival Oksitetrasiklin Enjeksiyonuna Karşı İntrapalpebral Enjeksiyon". Kocatepe Veteriner Dergisi 11 / 3 (Eylül 2018): 232-237. http://dx.doi.org/10.30607/kvj.408380